PMID: identifiant
de la référence Pubmed : |
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 (21760703)  |
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| titre : |
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TP53 status and response to treatment in breast cancers. |
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| auteur(s) : |
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Mariana Varna1, Guilhem Bousquet1, Louis-François Plassa2, Philippe Bertheau1, 3, Anne Janin ( ) 1, 3 |
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| laboratoire : |
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| résumé : |
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The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens. |
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| domaine : |
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Sciences du Vivant/Cancérologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1110-7243 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1155/2011/284584 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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2011 |
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date de publication
électronique : |
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09/05/2011 |
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| volume : |
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2011 |
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| page, identifiant, ... : |
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284584 |
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| Descripteur(s) MeSH : |
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Animals – Breast Neoplasms – Female – Genes – p53 – Humans – Mice – Mutation – Prognosis – Animals |
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| contrat, financement : |
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This work was supported by grants from Canceropole Ile de France. M. Varna and G. Bousquet were equally contributed |
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