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TP53 status and response to treatment in breast cancers.
Varna M., Bousquet G., Plassa L.-F., Bertheau P., Janin A.
Journal of Biomedicine and Biotechnology 2011 (2011) 284584 - http://www.hal.inserm.fr/inserm-00741097
TP53 status and response to treatment in breast cancers.
Mariana Varna1, Guilhem Bousquet1, Louis-François Plassa2, Philippe Bertheau1, 3, Anne Janin () 1, 3
1 :  Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique
INSERM : U728 – Université Paris VII - Paris Diderot
Hopital Saint-Louis - Centre Hayem PARIS VII 1, Avenue Claude Vellefaux 75475 PARIS CEDEX 10
2 :  Laboratoire de Biochimie
Hôpital Saint-Louis – Assistance publique - Hôpitaux de Paris (AP-HP) – Université Paris VII - Paris Diderot
1, Avenue Claude-Vellefaux - 75010 Paris
3 :  Service d'anatomo-pathologie
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Saint-Louis – Université Paris VII - Paris Diderot
1 avenue Claude Vellefaux 75475 Paris cedex 10
The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.
Sciences du Vivant/Cancérologie

Articles dans des revues avec comité de lecture
Journal of Biomedicine and Biotechnology
Publisher Hindawi Publishing Corporation
ISSN 1110-7243 (eISSN : 1110-7251)

Animals – Breast Neoplasms – Female – Genes – p53 – Humans – Mice – Mutation – Prognosis – Animals
This work was supported by grants from Canceropole Ile de France. M. Varna and G. Bousquet were equally contributed
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