PMID: identifiant
de la référence Pubmed : |
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 (21346181)  |
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| titre : |
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Are the same clinical risk factors relevant for incident diabetes defined by treatment, fasting plasma glucose, and HbA1c? |
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| auteur(s) : |
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Beverley Balkau ( ) 1, Soraya Soulimane1, Céline Lange1, Alain Gautier2, 3, Jean Tichet4, Sylviane Vol4, D.E.S.I.R. STUDY GROUP (Inter Regional Health Institute, IRSA, La Riche, F-37521 France) Collaboration(s) |
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| laboratoire : |
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| titre abrégé : |
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Risk factors: fasting glucose or HbA1c diabetes |
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| résumé : |
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OBJECTIVE: To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) ≥7.0 mmol/L, and HbA(1c) ≥6.5%. RESEARCH DESIGN AND METHODS: Participants aged 30-65 years from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort were followed for 9 years. RESULTS: More men had incident diabetes as defined by FPG ≥7.0 mmol/L and/or treatment than by HbA(1c) ≥6.5% and/or treatment: 7.5% (140/1,867) and 5.3% (99/1,874), respectively (P < 0.009); for women incidences were similar: 3.2% (63/1,958) and 3.4% (66/1,954). Known risk factors predicted diabetes for almost all definitions. Among those with incident diabetes by FPG alone versus HbA(1c) alone, there were more men (78 vs. 35%), case patients were 8 years younger, and fewer were alcohol abstainers (12 vs. 35%) (all P < 0.005). A diabetes risk score discriminated well between those with and without incident diabetes for all definitions. CONCLUSIONS: In men, FPG definitions yielded more incident cases of diabetes than HbA(1c) definitions, in contrast with women. An FPG-derived risk score remained relevant for HbA(1c)-defined diabetes. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1935-5548 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.2337/dc10-1581 |
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| journal : |
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| Diabetes Care (Diabetes Care) |
| Publisher |
American Diabetes Association |
| ISSN |
0149-5992 (eISSN : 0149-5992) |
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| Audience : |
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internationale |
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| date de publication : |
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04/2011 |
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date de publication
électronique : |
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23/02/2011 |
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| volume : |
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34 |
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| numéro : |
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4 |
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| page, identifiant, ... : |
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957-9 |
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| mots-clés auteur : |
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epidemiology – fasting plasma glucose – HbA1c – incidence – risk factors – type 2 diabetes |
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| Descripteur(s) MeSH : |
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Adult – Aged – Blood Glucose – Diabetes Mellitus – Type 2 – Female – Hemoglobin A – Glycosylated – Humans – Male – Middle Aged – Odds Ratio – Risk Factors – Adult |
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| contrat, financement : |
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The D.E.S.I.R. study has been supported by INSERM contracts with CNAMTS, Lilly, Novartis Pharma and Sanofi-Aventis; by INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé), Cohortes Santé TGIR, the Association Diabète Risque Vasculaire, the Fédération Française de Cardiologie, La Fondation de France, ALFEDIAM, ONIVINS, Société francophone du diabète , Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, Topcon. |
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