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Phylogenetic analysis of the human thyroglobulin regions.
Belkadi A., Jacques C., Savagner F., Malthièry Y.
Thyroid Research 5, 1 (2012) 3 - http://www.hal.inserm.fr/inserm-00738649
 (22549183) 
Phylogenetic analysis of the human thyroglobulin regions.
Abdelaziz Belkadi () 1, 2, Caroline Jacques1, Frédérique Savagner1, Yves Malthièry1
1 :  Mitochondrie : Régulations et Pathologie
http://lbbma.univ-angers.fr
INSERM : U694 – Université d'Angers
CHU 4, Rue Larrey 49033 Angers Cedex
France
2 :  Génétique Humaine des Maladies Infectieuses
INSERM : U980 – Université Paris V - Paris Descartes
site Necker 156 rue de Vaugirard - 75730 PARIS cedex 15
France
ABSTRACT: Thyroglobulin is a large protein present in all vertebrates. It is synthesized in the thyrocytes and exported to lumen of the thyroid follicle, where its tyrosine residues are iodinated . The iodinated thyroglobulin is reintegrated into the cell and processed (cleaved to free its two extremities) for thyroid hormone synthesis. Thyroglobulin sequence analysis has identified four regions of the molecule: Tg1, Tg2, Tg3 and ChEL. Structural abnormalities and mutations result in different pathological consequences, depending on the thyroglobulin region affected. We carried out a bioinformatic analysis of thyroglobulin, determining the origin and the function of each region. Our results suggest that the Tg1 region acts as a binding protein on the apical membrane, the Tg2 region is involved in protein adhesion and the Tg3 region is involved in determining the three-dimensional structure of the protein. The ChEL domain is involved in thyroglobulin transport, dimerization and adhesion. The presence of repetitive domains in the Tg1, Tg2 and Tg3 regions suggests that these domains may have arisen through duplication.
Sciences du Vivant/Bio-Informatique, Biostatistique
Informatique/Bio-informatique
Anglais
1756-6614

Articles dans des revues avec comité de lecture
10.1186/1756-6614-5-3
Thyroid Research (Thyroid Res)
Publisher BioMed Central
ISSN 1756-6614 
internationale
01/05/2012
01/05/2012
5
1
3

This work was supported by the regional organization BioInformatique Ligérienne (BIL) directed by Rémi Houlgatte
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