miR-21 and 221 upregulation and miR- 181b downregulation in human grade II-IV astrocytic tumors Characterization of microRNA expression levels and their biological correlates in human cancer cell lines Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal A mammalian microRNA expression atlas based on small RNA library sequencing, J Neurooncol Cancer Res Cancer Res Landgraf P, Rusu M Cell, vol.93, issue.1297, pp.325-332, 2007. ,
Gliomas display a microRNA expression profile reminiscent of neural precursor cells Identification and Functional Characterization of micro- RNAs Involved in the Malignant Progression of Gliomas RAKE and LNA- ISH reveal microRNA expression and localization in archival human brain MicroRNA Expression Signature in Human Glioblastoma Multiforme Brain Tumor, inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, pp.422-433, 2005. ,
Regulation of Epidermal Growth Factor Receptor Signaling in Human Cancer Cells by MicroRNA-7, Ref 11: data for ODG. (XLS) References, pp.5731-5741, 2009. ,
DOI : 10.1074/jbc.M804280200
Genetic alterations and signaling pathways in the evolution of gliomas, Cancer Science, vol.3, issue.12, pp.2235-2241, 2009. ,
DOI : 10.1111/j.1349-7006.2009.01308.x
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis, Cancer Cell, vol.9, issue.3, pp.157-173, 2006. ,
DOI : 10.1016/j.ccr.2006.02.019
Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes, Cancer Research, vol.69, issue.5, pp.2091-2099, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-2100
Emerging functions of microRNAs in glioblastoma, Journal of Neuro-Oncology, vol.7, issue.3, pp.297-306, 2009. ,
DOI : 10.1007/s11060-009-9843-2
microRNAs as oncogenes and tumor suppressors, Developmental Biology, vol.302, issue.1, pp.1-12, 2007. ,
DOI : 10.1016/j.ydbio.2006.08.028
Functional MicroRNA Is Transferred between Glioma Cells, Cancer Research, vol.70, issue.21, pp.8259-8263, 2010. ,
DOI : 10.1158/0008-5472.CAN-10-0604
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970756
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nature Cell Biology, vol.175, issue.6, pp.654-659, 2007. ,
DOI : 10.1002/pmic.200400876
Analysis of the IDH1 codon 132 mutation in brain tumors, Acta Neuropathologica, vol.6, issue.6, pp.597-602, 2008. ,
DOI : 10.1007/s00401-008-0455-2
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells, Cell, vol.134, issue.3, pp.521-533, 2008. ,
DOI : 10.1016/j.cell.2008.07.020
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells, Cancer Research, vol.67, issue.4, pp.1424-1429, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-4218
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells, Cancer Cell, vol.9, issue.6, pp.435-443, 2006. ,
DOI : 10.1016/j.ccr.2006.04.020
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia, Proceedings of the National Academy of Sciences, vol.104, issue.50, pp.19971-19976, 2007. ,
DOI : 10.1073/pnas.0709313104
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes, RNA, vol.11, issue.3, pp.241-247, 2005. ,
DOI : 10.1261/rna.7240905
Expression and Prognostic Significance of a Panel of Tissue Hypoxia Markers in Head-and-Neck Squamous Cell Carcinomas, International Journal of Radiation Oncology*Biology*Physics, vol.69, issue.1, pp.167-175, 2007. ,
DOI : 10.1016/j.ijrobp.2007.01.071
Hyaluronan-CD44 Interaction with Protein Kinase C?? Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells, Journal of Biological Chemistry, vol.284, issue.39, pp.26533-26546, 2009. ,
DOI : 10.1074/jbc.M109.027466
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44, The Journal of Cell Biology, vol.65, issue.6, pp.949-957, 2009. ,
DOI : 10.1083/jcb.200812060.dv
Deregulated expression of miR-106a predicts survival in human colon cancer patients, Genes, Chromosomes and Cancer, vol.9, issue.9, pp.794-802, 2008. ,
DOI : 10.1002/gcc.20580
A microRNA polycistron as a potential human oncogene, Nature, vol.1, issue.7043, pp.828-833, 2005. ,
DOI : 10.1093/BIOINFORMATICS/16.11.1046
Post-transcriptional regulation of microRNA expression, RNA, vol.12, issue.7, pp.1161-1167, 2006. ,
DOI : 10.1261/rna.2322506
A MicroRNA Signature of Hypoxia, Molecular and Cellular Biology, vol.27, issue.5, pp.1859-1867, 2007. ,
DOI : 10.1128/MCB.01395-06
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer, Clinical Cancer Research, vol.14, issue.5, pp.1340-1348, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-1755
NONCODING RNAS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM, Annual Review of Neuroscience, vol.29, issue.1, pp.77-103, 2006. ,
DOI : 10.1146/annurev.neuro.29.051605.112839
Mef2-mediated transcription of the miR379???410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels, The EMBO Journal, vol.14, issue.6, pp.697-710, 2009. ,
DOI : 10.1186/1471-2202-7-17
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes, Journal of Neuroscience, vol.28, issue.45, pp.11720-11730, 2008. ,
DOI : 10.1523/JNEUROSCI.1932-08.2008
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system, Genome Biology, vol.8, issue.8, p.173, 2007. ,
DOI : 10.1186/gb-2007-8-8-r173
URL : https://hal.archives-ouvertes.fr/hal-00325265
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation, Experimental Cell Research, vol.314, issue.14, pp.2618-2633, 2008. ,
DOI : 10.1016/j.yexcr.2008.06.002
Identification of Tissue-Specific MicroRNAs from Mouse, Current Biology, vol.12, issue.9, pp.735-739, 2002. ,
DOI : 10.1016/S0960-9822(02)00809-6
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, BMC Medicine, vol.6, issue.3, p.14, 2008. ,
DOI : 10.1158/1535-7163.MCT-06-0691
The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing, Molecular Cell, vol.27, issue.3, pp.435-448, 2007. ,
DOI : 10.1016/j.molcel.2007.07.015
Regulation of miRNA expression during neural cell specification, European Journal of Neuroscience, vol.21, issue.6, pp.1469-1477, 2005. ,
DOI : 10.1111/j.1460-9568.2005.03978.x
From The Cover: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis, Proceedings of the National Academy of Sciences, vol.102, issue.45, pp.16426-16431, 2005. ,
DOI : 10.1073/pnas.0508448102
Corrigendum: A brain-specific microRNA regulates dendritic spine development, Nature, vol.439, issue.7095, pp.283-311, 2006. ,
DOI : 10.1038/nature04909
MicroRNA and central nervous system], Brain Nerve, vol.61, issue.2, pp.167-176, 2009. ,
Role of Dicer and Drosha for Endothelial MicroRNA Expression and Angiogenesis, Circulation Research, vol.101, issue.1, pp.59-68, 2007. ,
DOI : 10.1161/CIRCRESAHA.107.153916
microRNAs in Gliomas: Small Regulators of a Big Problem, NeuroMolecular Medicine, vol.59, issue.3, pp.208-222, 2009. ,
DOI : 10.1007/s12017-009-8087-9
MicroRNAs and glioblastoma; the stem cell connection, Cell Death and Differentiation, vol.445, issue.2, pp.221-228, 2010. ,
DOI : 10.1523/JNEUROSCI.3219-08.2008
Oncogenic role of microRNAs in brain tumors, Acta Neuropathologica, vol.87, issue.6, pp.599-611, 2009. ,
DOI : 10.1007/s00401-009-0525-0
The many roles of microRNAs in brain tumor biology, Neurosurgical Focus, vol.28, issue.1, p.3, 2010. ,
DOI : 10.3171/2009.10.FOCUS09207
MiRNA-196 Is Upregulated in Glioblastoma But Not in Anaplastic Astrocytoma and Has Prognostic Significance, Clinical Cancer Research, vol.16, issue.16, pp.4289-4297, 2010. ,
DOI : 10.1158/1078-0432.CCR-10-0207
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-??8, Oncogene, vol.18, issue.7, pp.806-821, 2011. ,
DOI : 10.1158/0008-5472.CAN-08-0769
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship, Proceedings of the National Academy of Sciences, vol.107, issue.5, pp.2183-2188, 2010. ,
DOI : 10.1073/pnas.0909896107
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836668
The MicroRNA and MessengerRNA Profile of the RNA-Induced Silencing Complex in Human Primary Astrocyte and Astrocytoma Cells, PLoS ONE, vol.317, issue.10, p.13445, 2010. ,
DOI : 10.1371/journal.pone.0013445.s006
Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines, Brain, vol.132, issue.8, pp.2277-2288, 2009. ,
DOI : 10.1093/brain/awp153
Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas, Brain Pathology, vol.103, issue.3, pp.539-550, 2009. ,
DOI : 10.1111/j.1750-3639.2009.00328.x
MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes, Blood, vol.113, issue.2, pp.396-402, 2009. ,
DOI : 10.1182/blood-2008-07-163907
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells, International Journal of Cancer, vol.12, issue.2, pp.372-379, 2008. ,
DOI : 10.1002/ijc.23501
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster, Nature Genetics, vol.265, issue.9, pp.1060-1065, 2006. ,
DOI : 10.1056/NEJMoa032691
Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3-microRNA Cluster 17/92 Pathway, Circulation Research, vol.104, issue.10, pp.1184-1191, 2009. ,
DOI : 10.1161/CIRCRESAHA.109.197491
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation, Developmental Biology, vol.326, issue.2, pp.431-443, 2009. ,
DOI : 10.1016/j.ydbio.2008.11.016
Identification of Hypoxia-Inducible Factor-1?? as a Novel Target for miR-17-92 MicroRNA Cluster, Cancer Research, vol.68, issue.14, pp.5540-5545, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-6460
STAT3 tyrosine phosphorylation influences survival in glioblastoma, Journal of Neuro-Oncology, vol.4, issue.3, pp.339-343, 2010. ,
DOI : 10.1007/s11060-010-0195-8
Quantitative Phosphoproteomic Analysis of the STAT3/IL-6/HIF1?? Signaling Network: An Initial Study in GSC11 Glioblastoma Stem Cells, Journal of Proteome Research, vol.9, issue.1, pp.430-443, 2010. ,
DOI : 10.1021/pr9007927
The MicroRNA let-7a Modulates Interleukin-6-dependent STAT-3 Survival Signaling in Malignant Human Cholangiocytes, Journal of Biological Chemistry, vol.282, issue.11, pp.8256-8264, 2007. ,
DOI : 10.1074/jbc.M607712200
Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth, Stem Cells, vol.25, issue.10, pp.2393-2404, 2009. ,
DOI : 10.1002/stem.188
Down-Regulation of Stat3 Decreases Invasion Activity and Induces Apoptosis of Human Glioma Cells, Journal of Molecular Neuroscience, vol.78, issue.3, pp.353-359, 2010. ,
DOI : 10.1007/s12031-009-9323-3
Fatty Acid Synthesis from Glutamate in the Adipose Tissue of Normal Subjects and Obese Patients: An Enzyme Study, Biochemical and Molecular Medicine, vol.54, issue.1, pp.19-25, 1995. ,
DOI : 10.1006/bmme.1995.1003
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate, Nature, vol.50, issue.7274, pp.739-744, 2009. ,
DOI : 10.1038/nature08617
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818760
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2, Cell Metabolism, vol.10, issue.4, pp.273-284, 2009. ,
DOI : 10.1016/j.cmet.2009.08.015
MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells, Molecular Cell, vol.37, issue.5, pp.620-632, 2010. ,
DOI : 10.1016/j.molcel.2010.02.018
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells, Neuro-Oncology, vol.12, issue.11, pp.1102-1112, 2010. ,
DOI : 10.1093/neuonc/noq080
A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress, Cell Death and Differentiation, vol.258, issue.5, pp.738-748, 2009. ,
DOI : 10.1006/meth.2001.1262
A high throughput experimental approach to identify miRNA targets in human cells, Nucleic Acids Research, vol.37, issue.20, p.137, 2009. ,
DOI : 10.1093/nar/gkp715
The impact of microRNAs on protein output, Nature, vol.35, issue.7209, pp.64-71, 2008. ,
DOI : 10.1038/nature07242
Widespread changes in protein synthesis induced by microRNAs, Nature, vol.4, issue.7209, pp.58-63, 2008. ,
DOI : 10.1038/nature07228
Multiplex Ligation-Dependent Probe Amplification for the Detection of 1p and 19q Chromosomal Loss in Oligodendroglial Tumors, Brain Pathology, vol.129, issue.3, pp.192-197, 2005. ,
DOI : 10.1111/j.1750-3639.2005.tb00520.x
Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets, Cancer Research, vol.64, issue.15, pp.5245-5250, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-0496
Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR, Nucleic Acids Research, vol.30, issue.9, p.36, 2002. ,
DOI : 10.1093/nar/30.9.e36