| titre : |
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Age effect on the default mode network, inner thoughts and cognitive abilities |
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| auteur(s) : |
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Katell Mevel ( ) 1, Brigitte Landeau1, Marine Fouquet1, Renaud La Joie1, Nicolas Villain1, Florence Mézenge1, Audrey Perrotin1, Francis Eustache1, Beatrice Desgranges1, Gaël Chételat1 |
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| laboratoire : |
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| résumé : |
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Age-related effects on the Default Mode Network (DMN) connectivity as measured at rest using functional MRI (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts occurring during the resting-state scan, called as inner experience. Brain resting-state activity, inner experience and cognitive ability measurements were obtained in 70 participants aged 19 to 80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the impact of age-related changes in resting-state activity as measured with fMRI |
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| domaine : |
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Sciences du Vivant/Neurosciences
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langue du texte
intégral : |
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Anglais |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1016/j.neurobiolaging.2012.08.018 |
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| journal : |
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| Neurobiology of Aging (Neurobiol Aging) |
| Publisher |
Elsevier |
| ISSN |
0197-4580 |
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| Audience : |
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internationale |
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| date de publication : |
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07/09/2012 |
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| page, identifiant, ... : |
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10-16 |
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| mots-clés auteur : |
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aging – resting state – default mode network – functional connectivity – autobiographical memory – inner experience |
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| contrat, financement : |
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Programme Hospitalier de Recherche Clinique (PHRC National 2008), Région Basse Normandie and Institut National de la Santé et de la Recherche Médicale (Inserm). |
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| Projet ANR : |
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| Référence du projet |
ANR LONGVIE 2007 |
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