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Robust Cerebral Blood Flow Map Estimation in Arterial Spin Labeling
Maumet C., Maurel P., Ferré J.-C., Barillot C.
Dans MICCAI 2012 Workshop on Multimodal Brain Image Analysis - International Workshop on Multimodal Brain Image Analysis (MBIA), held in conjunction with MICCAI 2012, Nice : France (2012) - http://www.hal.inserm.fr/inserm-00724974
Robust Cerebral Blood Flow Map Estimation in Arterial Spin Labeling
Camille Maumet () 1, Pierre Maurel1, Jean-Christophe Ferré1, 2, Christian Barillot1
1 :  VISAGES - VISAGES : Vision Action et Gestion d'Informations en Santé
http://www.inria.fr/equipes/visages
INSERM : U746 – CNRS : UMR6074 – INRIA – Université de Rennes 1
IRISA, campus de Beaulieu F-35042 Rennes
France
2 :  Service de radiologie et imagerie médicale [Rennes]
CHU Rennes – Université de Rennes 1 – Hôpital Pontchaillou
Hôpital Pontchaillou 2 rue Henri Le Guilloux 35033 Rennes cedex 9
France
Non-invasive measurement of Cerebral Blood Flow (CBF) is now feasible thanks to the introduction of Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI) techniques. To date, the low signal-to-noise ratio of ASL gives us no option but to repeat the acquisition in order to accumulate enough data to get a reliable signal. Perfusion signal is usually extracted by averaging across the repetitions. However, due to its zero breakdown point, the sample mean is very sensitive to outliers. A single outlier can thus have strong detrimental effects on the sample mean estimate. In this paper, we propose to estimate robust ASL CBF maps by means of M-estimators to overcome the deleterious effects of outliers. The behavior of this method is compared to z-score thresholding as recommended in [8]. validation on simulated and real data is provided. Quantitative validation is undertaken by measuring the correlation with the most widespread technique to measure perfusion with MRI: Dynamic Susceptibility weighted Contrast (DSC).
Sciences du Vivant/Neurosciences
Anglais

Communications avec actes
MICCAI 2012 Workshop on Multimodal Brain Image Analysis
internationale
01/10/2012
215-224

International Workshop on Multimodal Brain Image Analysis (MBIA), held in conjunction with MICCAI 2012
10/2012
Nice
France

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