Targeting tetraspanins in cancer.

Abstract : Introduction: Tetraspanins are a family of small proteins that cross the membrane four times and form complexes by interacting between themselves and with a variety of transmembrane and cytosolic proteins, building a network of interactions referred to as tetraspanin web or tetraspanin enriched microdomains (TEMs). These domains provide a signaling platform involved in many important cellular functions and malignant processes. Areas covered: The authors describe the methods and the rationale for targeting tetraspanins in the therapy of cancer in this review. Expert opinion: Targeting tetraspanins in cancer may be a promising therapy due to the importance of tetraspanins in several steps of tumor formation, communication with the environment, dissemination, and metastasis.
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Expert Opinion on Therapeutic Targets, Taylor & Francis, 2012, 32 (1), epub ahead of print. 〈10.1517/14728222.2012.712688〉
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Monica Sala-Valdes, Naouel Ailane, Céline Greco, Eric Rubinstein, Claude Boucheix. Targeting tetraspanins in cancer.. Expert Opinion on Therapeutic Targets, Taylor & Francis, 2012, 32 (1), epub ahead of print. 〈10.1517/14728222.2012.712688〉. 〈inserm-00724944〉

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