PMID: identifiant
de la référence Pubmed : |
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 (22632376)  |
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Default in plasma and intestinal IgA responses during acute infection by Simian Immunodeficiency Virus. |
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| auteur(s) : |
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Nada Chaoul1, Chantal Burelout1, Sandrine Peruchon1, 2, Beatrice van Buu3, Pascale Laurent3, Alexis Proust4, 5, Martine Raphael4, 5, Olivier Garraud2, Roger Le Grand1, Sophie Prevot3, Yolande Richard ( ) 1, 6 |
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| résumé : |
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ABSTRACT: BACKGROUND: Conflicting results regarding changes in mucosal IgA production or in the proportions of IgA plasma cells in the small and large intestines during HIV-infection have been previously reported. Except in individuals repeatedly exposed to HIV-1 but yet remaining uninfected, HIV-specific IgA are frequently absent in mucosal secretions from HIV-infected patients. However, little is known about the organization and functionality of mucosal B-cell follicles in acute HIV/SIV infection during which a T-dependent IgA response should have been initiated. In the present study, we evaluated changes in B-cell and T-cell subsets as well as the extent of apoptosis and class-specific plasma cells in Peyer's Patches, isolated lymphoid follicles, and lamina propria. Plasma levels of IgA, BAFF and APRIL were also determined. RESULTS: Plasma IgA level was reduced by 46 percent by 28 dpi and no IgA plasma cells were found within germinal centers of Peyer's Patches and isolated lymphoid follicles. This lack of a T-dependent IgA response occurs although germinal centers remained functional with no sign of follicular damage, but a prolonged survival of follicular CD4+ T-cells and normal generation of IgG plasma cells is observed. Whereas the average plasma BAFF level was increased by 4.5-fold and total plasma cells were 1.7 to 1.9-fold more numerous in the lamina propria, the relative proportion of IgA plasma cells in this effector site was reduced by 19 percent (duodemun) to 35 percent (Ileum) at 28 dpi. CONCLUSION: Our data provide evidence that SIV is unable to initiate a T-dependent IgA response during the acute phase of infection and favors the production of IgG (ileum) or IgM (duodenum) plasma cells at the expense of IgA plasma cells. Therefore, an early and generalized default in IgA production takes place during the acute of phase of HIV/SIV infection, which might impair not only a virus-specific antibody response but also IgA responses to other pathogens and vaccines as well. Understanding the mechanisms that impair IgA production during acute HIV/SIV infection is crucial to improve virus-specific response in mucosa and control microbial translocation. |
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| domaine : |
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Sciences du Vivant/Médecine humaine et pathologie/Maladies infectieuses
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1742-4690 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1186/1742-4690-9-43 |
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| Audience : |
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internationale |
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| date de publication : |
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25/05/2012 |
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date de publication
électronique : |
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25/05/2012 |
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| volume : |
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9 |
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| numéro : |
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1 |
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| page, identifiant, ... : |
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43 |
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| mots-clés auteur : |
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Mucosal B-cell response – IgA – HIV/SIV – Germinal centers – BAFF – Terminal ileum |
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