Spatial learning depends on both the addition and removal of new hippocampal neurons.

Abstract : The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons.
Type de document :
Article dans une revue
PLoS Biology, Public Library of Science, 2007, 5 (8), pp.e214. 〈10.1371/journal.pbio.0050214〉
Liste complète des métadonnées

Littérature citée [57 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00708252
Contributeur : Delphine Autard <>
Soumis le : jeudi 14 juin 2012 - 14:14:47
Dernière modification le : mercredi 10 janvier 2018 - 18:08:11
Document(s) archivé(s) le : samedi 15 septembre 2012 - 02:46:05

Fichier

journal.pbio.0050214.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

David Dupret, Annabelle Fabre, Màtè Dàniel Döbrössy, Aude Panatier, José Julio Rodríguez, et al.. Spatial learning depends on both the addition and removal of new hippocampal neurons.. PLoS Biology, Public Library of Science, 2007, 5 (8), pp.e214. 〈10.1371/journal.pbio.0050214〉. 〈inserm-00708252〉

Partager

Métriques

Consultations de la notice

399

Téléchargements de fichiers

314