E. Albuquerque, E. Pereira, M. Alkondon, and S. Rogers, Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function, Physiological Reviews, vol.89, issue.1, pp.73-120, 2009.
DOI : 10.1152/physrev.00015.2008

R. Drisdel and W. Green, Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers, J Neurosci, vol.20, pp.133-139, 2000.

J. Lindstrom, Structures of neuronal nicotinic receptors, Neuronal nicotinic receptors, pp.101-162, 2000.

A. Karlin, ION CHANNEL STRUCTUREEMERGING STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTORS, Nature Reviews Neuroscience, vol.3, issue.2, pp.102-114, 2002.
DOI : 10.1038/nrn731

N. Unwin, Refined Structure of the Nicotinic Acetylcholine Receptor at 4?? Resolution, Journal of Molecular Biology, vol.346, issue.4, pp.967-989, 2005.
DOI : 10.1016/j.jmb.2004.12.031

A. Jones, P. Davis, J. Hodgkin, and D. Sattelle, The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature, Invertebrate Neuroscience, vol.440, issue.2, pp.129-131, 2007.
DOI : 10.1007/s10158-007-0049-z

J. Rand, Acetylcholine, WormBook, vol.30, pp.1-21, 2007.
DOI : 10.1895/wormbook.1.131.1

J. Lewis, C. Wu, J. Levine, and H. Berg, Levamisole-resitant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors, Neuroscience, vol.5, issue.6, pp.967-989, 1980.
DOI : 10.1016/0306-4522(80)90180-3

J. Fleming, M. Squire, T. Barnes, C. Tornoe, and K. Matsuda, Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits, J Neurosci, vol.17, pp.5843-5857, 1997.

E. Culetto, H. Baylis, J. Richmond, A. Jones, and J. Fleming, The Caenorhabditis elegans unc-63 Gene Encodes a Levamisole-sensitive Nicotinic Acetylcholine Receptor ?? Subunit, Journal of Biological Chemistry, vol.279, issue.41, pp.42476-42783, 2004.
DOI : 10.1074/jbc.M404370200

URL : https://hal.archives-ouvertes.fr/hal-00198541

P. Towers, B. Edwards, J. Richmond, and D. Sattelle, The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit, Journal of Neurochemistry, vol.19, issue.1, pp.1-9, 2005.
DOI : 10.1038/nature00891

L. Brown, A. Jones, S. Buckingham, C. Mee, and D. Sattelle, Contributions from Caenorhabditis elegans functional genetics to antiparasitic drug target identification and validation: Nicotinic acetylcholine receptors, a case study, International Journal for Parasitology, vol.36, issue.6, pp.617-624, 2006.
DOI : 10.1016/j.ijpara.2006.01.016

T. Boulin, M. Gielen, J. Richmond, D. Williams, and P. Paoletti, Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor, Proceedings of the National Academy of Sciences, vol.105, issue.47, pp.18590-18595, 2008.
DOI : 10.1073/pnas.0806933105

A. Jones and D. Sattelle, Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode,Caenorhabditis elegans, BioEssays, vol.129, issue.1, pp.39-49, 2004.
DOI : 10.1002/bies.10377

J. White, E. Southgate, J. Thomson, and S. Brenner, The Structure of the Ventral Nerve Cord of Caenorhabditis elegans, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.275, issue.938, pp.327-348, 1976.
DOI : 10.1098/rstb.1976.0086

S. Mcintire, E. Jorgensen, and H. Horvitz, Genes required for GABA function in Caenorhabditis elegans, Nature, vol.364, issue.6435, pp.334-337, 1993.
DOI : 10.1038/364334a0

M. Squire, C. Tornøe, H. Baylis, J. Fleming, and E. Barnard, Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2), Recept Channels, vol.3, pp.107-115, 1995.

H. Baylis, K. Matsuda, M. Squire, J. Fleming, and R. Harvey, ACR- 3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression, Recept Channels, vol.5, pp.149-158, 1997.

P. Charnet, C. Labarca, R. Leonard, N. Vogelaar, and L. Czyzyk, An open-channel blocker interacts with adjacent turns of ??-helices in the nicotinic acetylcholine receptor, Neuron, vol.4, issue.1, pp.87-95, 1990.
DOI : 10.1016/0896-6273(90)90445-L

A. Keramidas, A. Moorhouse, P. Schofield, and P. Barry, Ligand-gated ion channels: mechanisms underlying ion selectivity, Progress in Biophysics and Molecular Biology, vol.86, issue.2, pp.161-204, 2004.
DOI : 10.1016/j.pbiomolbio.2003.09.002

M. Treinin and M. Chalfie, A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans, Neuron, vol.14, issue.4, pp.871-877, 1995.
DOI : 10.1016/0896-6273(95)90231-7

A. Engel, K. Ohno, M. Milone, H. Wang, and S. Nakano, New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome, Human Molecular Genetics, vol.5, issue.9, pp.1217-1227, 1996.
DOI : 10.1093/hmg/5.9.1217

W. Varanda, Y. Aracava, S. Sherby, W. Vanmeter, and M. Eldefrawi, The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist, Mol Pharmacol, vol.28, pp.128-137, 1985.

A. Vashlishan, J. Madison, M. Dybbs, J. Bai, and D. Sieburth, An RNAi Screen Identifies Genes that Regulate GABA Synapses, Neuron, vol.58, issue.3, pp.346-361, 2008.
DOI : 10.1016/j.neuron.2008.02.019

H. Muller, Further studies on the nature and causes of gene mutations, Proc 6th Int Congr Genet, vol.1, pp.213-255, 1932.

J. White, E. Southgate, J. Thomson, and S. Brenner, The Structure of the Nervous System of the Nematode Caenorhabditis elegans, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.314, issue.1165, pp.1-340, 1986.
DOI : 10.1098/rstb.1986.0056

W. Lee, C. Free, and S. Sine, Nicotinic Receptor Interloop Proline Anchors ??1-??2 and Cys loops in Coupling Agonist Binding to Channel Gating, The Journal of General Physiology, vol.385, issue.2, pp.265-278, 2008.
DOI : 10.1006/jmbi.1996.0309

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483337

J. Richmond and E. Jorgensen, One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction, Nature Neuroscience, vol.2, issue.9, pp.791-797, 1999.
DOI : 10.1038/12160

K. Schuske, A. Beg, and E. Jorgensen, The GABA nervous system in C. elegans, Trends in Neurosciences, vol.27, issue.7, pp.407-414, 2004.
DOI : 10.1016/j.tins.2004.05.005

S. Eimer, A. Gottschalk, M. Hengartner, H. Horvitz, and J. Richmond, Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50, The EMBO Journal, vol.119, issue.20, pp.4313-4323, 2007.
DOI : 10.1038/sj.emboj.7601858

H. Cinar, S. Keles, and J. Y. , Expression Profiling of GABAergic Motor Neurons in Caenorhabditis elegans, Current Biology, vol.15, issue.4, pp.340-346, 2005.
DOI : 10.1016/j.cub.2005.02.025

A. Gottschalk, R. Almedom, T. Schedletzky, S. Anderson, and J. Yates, Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans, The EMBO Journal, vol.19, issue.14, pp.2566-2578, 2005.
DOI : 10.1038/sj.emboj.7600741

S. Halevi, J. Mckay, M. Palfreyman, L. Yassin, and M. Eshel, The C.elegansric-3 gene is required for maturation of nicotinic acetylcholine receptors, The EMBO Journal, vol.21, issue.5, pp.1012-1020, 2002.
DOI : 10.1093/emboj/21.5.1012

S. Hansen and P. Taylor, Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-??-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors, Journal of Molecular Biology, vol.369, issue.4, pp.895-901, 2007.
DOI : 10.1016/j.jmb.2007.03.067

J. Galzi, A. Devillers-thiery, N. Hussy, S. Bertrand, and J. Changeux, Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic, Nature, vol.359, issue.6395, pp.500-505, 1992.
DOI : 10.1038/359500a0

J. Galzi, S. Edelstein, and J. Changeux, The multiple phenotypes of allosteric receptor mutants., Proceedings of the National Academy of Sciences, vol.93, issue.5, pp.1853-1858, 1996.
DOI : 10.1073/pnas.93.5.1853

D. Bertrand, J. Galzi, A. Devillers-thiéry, S. Bertrand, and J. Changeux, Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor., Proceedings of the National Academy of Sciences, vol.90, issue.15, pp.6971-6975, 1993.
DOI : 10.1073/pnas.90.15.6971

Y. Jin, E. Jorgensen, E. Hartwieg, and H. Horvitz, The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development, J Neurosci, vol.19, pp.539-548, 1999.

B. Bamber, A. Beg, R. Twyman, and E. Jorgensen, The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor, J Neurosci, vol.19, pp.5348-5359, 1999.

Z. Wang, O. Saifee, M. Nonet, and L. Salkoff, SLO-1 Potassium Channels Control Quantal Content of Neurotransmitter Release at the C. elegans Neuromuscular Junction, Neuron, vol.32, issue.5, pp.867-881, 2001.
DOI : 10.1016/S0896-6273(01)00522-0

E. Mann and I. Mody, The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy, Current Opinion in Neurology, vol.21, issue.2, pp.155-160, 2008.
DOI : 10.1097/WCO.0b013e3282f52f5f

J. Stitzel, Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice, Frontiers in Bioscience, vol.13, issue.13, pp.477-491, 2008.
DOI : 10.2741/2694

S. Brenner, The genetics of Caenorhabditis elegans, Genetics, vol.77, pp.71-94, 1974.

S. Wicks, R. Yeh, W. Gish, R. Waterston, and R. Plasterk, Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map, Nature Genetics, vol.28, issue.2, pp.160-164, 2001.
DOI : 10.1038/88878

M. Davis, M. Hammarlund, T. Harrach, P. Hullett, and S. Olsen, Rapid single nucleotide polymorphism mapping in C. elegans, BMC Genomics, vol.6, issue.1, p.118, 2005.
DOI : 10.1186/1471-2164-6-118

J. Sambrook, E. Fritsch, and T. Maniatis, Molecular cloning: a laboratory manual, 1989.

A. Coulson, J. Sulston, S. Brenner, and J. Karn, Toward a physical map of the genome of the nematode Caenorhabditis elegans, Proceedings of the National Academy of Sciences, vol.83, issue.20, pp.7821-7825, 1986.
DOI : 10.1073/pnas.83.20.7821

C. Mello, J. Kramer, D. Stinchcomb, and A. V. , Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences, EMBO J, vol.10, pp.3959-3970, 1991.

A. Ruaud and J. Bessereau, Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans, Development, vol.133, issue.11, pp.2211-2222, 2006.
DOI : 10.1242/dev.02392

J. White, T. Nicholas, J. Gritton, L. Truong, and E. Davidson, The Sensory Circuitry for Sexual Attraction in C. elegans Males, Current Biology, vol.17, issue.21, pp.1847-1857, 2007.
DOI : 10.1016/j.cub.2007.09.011

B. Hille, A. Woodhull, and B. Shapiro, Negative Surface Charge Near Sodium Channels of Nerve: Divalent Ions, Monovalent Ions, and pH [and Discussion], Philosophical Transactions of the Royal Society B: Biological Sciences, vol.270, issue.908, pp.301-318, 1975.
DOI : 10.1098/rstb.1975.0011