Genome maintenance mechanisms for preventing cancer, Nature, vol.411, issue.6835, pp.366-374, 2001. ,
DOI : 10.1038/35077232
DNA Repair, Genome Stability, and Aging, Cell, vol.120, issue.4, pp.497-512, 2005. ,
DOI : 10.1016/j.cell.2005.01.028
URL : http://doi.org/10.1016/j.cell.2005.01.028
Defective DNA Repair and Neurodegenerative Disease, Cell, vol.130, issue.6, pp.991-1004, 2007. ,
DOI : 10.1016/j.cell.2007.08.043
URL : http://doi.org/10.1016/j.cell.2007.08.043
A single ataxia telangiectasia gene with a product similar to PI-3 kinase, Science, vol.268, issue.5218, pp.1749-1753, 1995. ,
DOI : 10.1126/science.7792600
The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder, Cell, vol.99, issue.6, pp.577-587, 1999. ,
DOI : 10.1016/S0092-8674(00)81547-0
Clinical and genetic heterogeneity of Seckel syndrome, American Journal of Medical Genetics, vol.32, issue.4, pp.379-383, 2002. ,
DOI : 10.1002/ajmg.10677
The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response, Cell, vol.93, issue.3, pp.477-486, 1998. ,
DOI : 10.1016/S0092-8674(00)81175-7
A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability, Molecular Cell, vol.35, issue.2, pp.228-239, 2009. ,
DOI : 10.1016/j.molcel.2009.06.021
URL : http://doi.org/10.1016/j.molcel.2009.06.021
DNA Double-Strand Break Repair: All's Well that Ends Well, Annual Review of Genetics, vol.40, issue.1, pp.363-383, 2006. ,
DOI : 10.1146/annurev.genet.40.110405.090451
Mechanisms of double-strand break repair in somatic mammalian cells, Biochemical Journal, vol.14, issue.2, pp.157-168, 2009. ,
DOI : 10.1534/genetics.104.033902
Regulation of DNA double-strand break repair pathway choice, Cell Research, vol.1, issue.1, pp.134-147, 2008. ,
DOI : 10.1038/nature04866
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity, DNA Repair, vol.7, issue.12, pp.2010-2019, 2008. ,
DOI : 10.1016/j.dnarep.2008.08.014
Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions, Molecular and Cellular Biology, vol.26, issue.24, pp.9377-9386, 2006. ,
DOI : 10.1128/MCB.01229-06
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins, Cell, vol.136, issue.3, pp.435-446, 2009. ,
DOI : 10.1016/j.cell.2008.12.041
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage, Cell, vol.136, issue.3, pp.420-434, 2009. ,
DOI : 10.1016/j.cell.2008.12.042
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies, Nature Methods, vol.132, pp.337-344, 2007. ,
DOI : 10.1093/NAR/30.1.281
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells, Genes & Development, vol.13, issue.20, pp.2633-2638, 1999. ,
DOI : 10.1101/gad.13.20.2633
Molecular views of recombination proteins and their control, Nature Reviews Molecular Cell Biology, vol.4, issue.6, pp.435-445, 2003. ,
DOI : 10.1038/nrm1127
Manipulating the mammalian genome by homologous recombination, Proceedings of the National Academy of Sciences, vol.98, issue.15, pp.8403-8410, 2001. ,
DOI : 10.1073/pnas.111009698
The Mechanism of Human Nonhomologous DNA End Joining, Journal of Biological Chemistry, vol.283, issue.1, pp.1-5, 2008. ,
DOI : 10.1074/jbc.R700039200
Knockout of the DNA ligase IV homolog gene in the sphingoid base producing yeast Pichia ciferrii significantly increases gene targeting efficiency, Current Genetics, vol.31, issue.4, 2009. ,
DOI : 10.1007/s00294-009-0252-z
Genetic Analysis of Zinc-Finger Nuclease-Induced Gene Targeting in Drosophila, Genetics, vol.182, issue.3, pp.641-651, 2009. ,
DOI : 10.1534/genetics.109.101329
Human DNA Repair Genes, Science, vol.291, issue.5507, pp.1284-1289, 2001. ,
DOI : 10.1126/science.1056154
Human DNA Repair Genes, Science, vol.291, issue.5507, pp.275-283, 2005. ,
DOI : 10.1126/science.1056154
E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases, The EMBO Journal, vol.300, issue.20, pp.3185-3195, 2009. ,
DOI : 10.1038/emboj.2009.258
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis, EMBO reports, vol.5, issue.9, pp.907-915, 2008. ,
DOI : 10.1074/jbc.C400139200
The Involvement of Mismatch Repair in Transcription Coupled Nucleotide Excision Repair, Human Cell, vol.64, issue.3, pp.103-115, 2005. ,
DOI : 10.1111/j.1749-0774.2005.tb00001.x
Direct and indirect roles of RECQL4 in modulating base excision repair capacity, Human Molecular Genetics, vol.18, issue.18, pp.3470-3483, 2009. ,
DOI : 10.1093/hmg/ddp291
Polymorphism in nucleotide excision repair geneXPC correlates with bleomycin-induced chromosomal aberrations, Environmental and Molecular Mutagenesis, vol.11, issue.8, pp.666-671, 2007. ,
DOI : 10.1002/em.20333
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability, Journal of Cell Science, vol.118, issue.18, pp.4261-4269, 2005. ,
DOI : 10.1242/jcs.02556
Inhibitors of the Proteasome Suppress Homologous DNA Recombination in Mammalian Cells, Cancer Research, vol.67, issue.18, pp.8536-8543, 2007. ,
DOI : 10.1158/0008-5472.CAN-07-1166
The proteasome is involved in determining differential utilization of double-strand break repair pathways, Oncogene, vol.297, issue.54, pp.7601-7606, 2007. ,
DOI : 10.1038/sj.onc.1210579
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells, EMBO reports, vol.19, issue.10, pp.989-993, 2004. ,
DOI : 10.1126/science.297.5588.1837
Mitomycin C: small, fast and deadly (but very selective), Chemistry & Biology, vol.2, issue.9, pp.575-579, 1995. ,
DOI : 10.1016/1074-5521(95)90120-5
URL : http://doi.org/10.1016/1074-5521(95)90120-5
Cellular processing of platinum anticancer drugs, Nature Reviews Drug Discovery, vol.11, issue.4, pp.307-320, 2005. ,
DOI : 10.1016/0006-2952(88)90325-5
DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability, Prog Nucleic Acid Res Mol Biol, vol.35, pp.95-125, 1988. ,
DOI : 10.1016/S0079-6603(08)60611-X
Human CtIP promotes DNA end resection, Nature, vol.278, issue.7169, pp.509-514, 2007. ,
DOI : 10.1038/nature06337
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409435
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks, Journal of Biological Chemistry, vol.276, issue.45, pp.42462-42467, 2001. ,
DOI : 10.1074/jbc.C100466200
Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress, J Biol Chem, vol.276, pp.47759-47762, 2001. ,
A phosphatase complex that dephosphorylates ??H2AX regulates DNA damage checkpoint recovery, Nature, vol.7, issue.7075, pp.497-501, 2006. ,
DOI : 10.1038/nature04384
Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase, Journal of Biological Chemistry, vol.271, issue.41, pp.25452-25458, 1996. ,
DOI : 10.1074/jbc.271.41.25452
Fiz1, a Novel Zinc Finger Protein Interacting with the Receptor Tyrosine Kinase Flt3, Journal of Biological Chemistry, vol.274, issue.30, pp.21478-21484, 1999. ,
DOI : 10.1074/jbc.274.30.21478
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells, Proceedings of the National Academy of Sciences, vol.102, issue.7, pp.2396-2401, 2005. ,
DOI : 10.1073/pnas.0409861102
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals, Nat Methods, 2008. ,
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A, The Journal of Cell Biology, vol.182, issue.2, pp.289-300, 2008. ,
DOI : 10.1038/2417
Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum, Nature Genetics, vol.5, issue.3, pp.366-372, 2007. ,
DOI : 10.1093/nar/30.1.166
URL : https://hal.archives-ouvertes.fr/hal-00281704
Identification of the SPG15 Gene, Encoding Spastizin, as a Frequent Cause of Complicated Autosomal-Recessive Spastic Paraplegia, Including Kjellin Syndrome, The American Journal of Human Genetics, vol.82, issue.4, pp.992-1002, 2008. ,
DOI : 10.1016/j.ajhg.2008.03.004
URL : https://hal.archives-ouvertes.fr/hal-00281715
Recent advances in the genetics of spastic paraplegias, Current Neurology and Neuroscience Reports, vol.116, issue.3, pp.198-210, 2008. ,
DOI : 10.1007/s11910-008-0032-z
URL : https://hal.archives-ouvertes.fr/inserm-00305275
Hereditary Spastic Paraplegia With Mental Impairment and Thin Corpus Callosum in Tunisia, Archives of Neurology, vol.65, issue.3, pp.393-402, 2008. ,
DOI : 10.1001/archneur.65.3.393
URL : https://hal.archives-ouvertes.fr/inserm-00277198
SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum, Neurology, vol.73, issue.14, pp.1111-1119, 2009. ,
DOI : 10.1212/WNL.0b013e3181bacf59
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage, Science, vol.316, issue.5828, pp.1160-1166, 2007. ,
DOI : 10.1126/science.1140321
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division, The EMBO Journal, vol.4, issue.10, pp.1453-1465, 2009. ,
DOI : 10.1038/82449
Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins, Science, vol.328, issue.5978, pp.593-599, 2010. ,
DOI : 10.1126/science.1181348
Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells, Nature Methods, vol.132, issue.10, pp.779-784, 2005. ,
DOI : 10.1073/pnas.192559699
Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods, The Journal of Immunology, vol.176, issue.4, pp.2069-2073, 2006. ,
DOI : 10.4049/jimmunol.176.4.2069
A new logic for DNA engineering using recombination in Escherichia coli, Nature Genetics, vol.20, issue.2, pp.123-128, 1998. ,
DOI : 10.1038/2417
In-gel digestion for mass spectrometric characterization of proteins and proteomes, Nature Protocols, vol.5, issue.6, pp.2856-2860, 2006. ,
DOI : 10.1038/nprot.2006.468
Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment, Genome Biology, vol.9, issue.11, p.167, 2008. ,
DOI : 10.1186/gb-2008-9-11-r167
Separating the Wheat from the Chaff: Unbiased Filtering of Background Tandem Mass Spectra Improves Protein Identification, Journal of Proteome Research, vol.7, issue.8, pp.3382-3395, 2008. ,
DOI : 10.1021/pr800140v
CLASSIFICATION OF THE HEREDITARY ATAXIAS AND PARAPLEGIAS, The Lancet, vol.321, issue.8334, pp.1151-1155, 1983. ,
DOI : 10.1016/S0140-6736(83)92879-9
Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration, Brain, vol.131, issue.3, pp.772-784, 2008. ,
DOI : 10.1093/brain/awm293
URL : https://hal.archives-ouvertes.fr/hal-00281713
CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5, Brain, vol.132, issue.6, pp.1589-1600, 2009. ,
DOI : 10.1093/brain/awp073
Exon deletions of SPG4 are a frequent cause of hereditary spastic paraplegia, Journal of Medical Genetics, vol.44, issue.4, pp.281-284, 2007. ,
DOI : 10.1136/jmg.2006.046425