Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Fibrogenesis & Tissue Repair Année : 2012

Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa

Saad Hamama
  • Fonction : Auteur
  • PersonId : 926002
Virginie Monceau
  • Fonction : Auteur
  • PersonId : 926004

Résumé

Chronic toxicities of locoregional and systemic oncological treatments commonly develop in long-term cancer survivors. Amongst these toxicities, post-radiotherapeutic complications alter patient's quality of life. Reduction of exposure of normal tissues can be achieved by optimization of radiotherapy. Furthermore, understanding of the fibrogenic mechanisms has provided targets to prevent, mitigate, and reverse late radiation-induced damages. This mini-review shows how (i) global molecular studies using gene profiling can provide tools to develop new intervention strategies and (ii) how successful clinical trials, conducted in particular with combined pentoxifylline-vitamin E, can take benefice of biological and molecular evidences to improve our understanding of fibrogenic mechanisms, enhance the robustness of proposed treatments, and lead ultimately to better treatments for patient's benefice.
Fichier principal
Vignette du fichier
1755-1536-5-S1-S13.pdf (192.08 Ko) Télécharger le fichier
1755-1536-5-S1-S13.xml (63.01 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00704842 , version 1 (06-06-2012)

Identifiants

  • HAL Id : inserm-00704842 , version 1

Citer

Saad Hamama, Sylvie Delanian, Virginie Monceau, Marie-Catherine Vozenin. Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa. Fibrogenesis & Tissue Repair, 2012, 5 (Suppl 1), pp.S13. ⟨inserm-00704842⟩
102 Consultations
163 Téléchargements

Partager

Gmail Facebook X LinkedIn More