The CEPAC-International investigators include: Massachusetts General Hospital, Harvard Medical School Hospital ,
University of Cape Town (Cape Town, South Africa): Robin Wood, Y.R. Gaitonde Centre for AIDS Research & Education Perinatal HIV Research Unit, WITS Health Consortium ,
Author Contributions ICMJE criteria for authorship read and met: Agree with the manuscript's results and conclusions: Designed the experiments/the study: EL HT XA FD. Analyzed the data: EL RPW KAF Collected data/did experiments for the study: HT XA. Wrote the first draft of the paper: EL HT, Conducted model analyses: LMU. Assisted in model development and updating: ADP. Provided methodologic guidance and helped developed the model: MCW. Co-developed the model ,
Medium-term survival, morbidity and immunovirological evolution in HIVinfected adults receiving antiretroviral therapy, Antivir Ther, vol.8, pp.385-393, 2003. ,
Lessons Learned from Use of Highly Active Antiretroviral Therapy in Africa, Clinical Infectious Diseases, vol.41, issue.3, pp.376-385, 2005. ,
DOI : 10.1086/431482
Efficacy of Antiretroviral Therapy Programs in Resource???Poor Settings: A Meta???analysis of the Published Literature, Clinical Infectious Diseases, vol.41, issue.2, pp.217-224, 2005. ,
DOI : 10.1086/431199
Implementation of an Antiretroviral Access Program for HIV-1-Infected Individuals in Resource-Limited Settings, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.44, issue.3, pp.262-267, 2007. ,
DOI : 10.1097/QAI.0b013e31802bf109
Efficacy of antiretroviral therapy in Africa: effect on immunological and virological outcome measures - a meta-analysis, International Journal of STD & AIDS, vol.19, issue.5, 2008. ,
DOI : 10.1258/ijsa.2007.007248
Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, S Afr Med J, vol.96, pp.315-320, 2006. ,
Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment, The Lancet, vol.367, issue.9519, pp.1335-1342, 2006. ,
DOI : 10.1016/S0140-6736(06)68580-2
Rapid Scale-up of Antiretroviral Therapy at Primary Care Sites in Zambia, JAMA, vol.296, issue.7, pp.782-793, 2006. ,
DOI : 10.1001/jama.296.7.782
Scaling up ART treatment capacity: Lessons learned from South Africa, Zimbabwe, and Botswana, Current HIV/AIDS Reports, vol.83, issue.2, pp.94-98, 2008. ,
DOI : 10.1007/s11904-008-0015-3
Rapid scaling-up of antiretroviral therapy in 10 000 adults in C??te d??Ivoire: 2-year outcomes and determinants, AIDS, vol.22, issue.7, pp.873-882, 2008. ,
DOI : 10.1097/QAD.0b013e3282f768f8
Towards Universal Access: Scaling up priority HIV/AIDS interventions in the health sector, Progress Report, 2008. ,
Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries, Lancet, vol.367, pp.817-824, 2006. ,
Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review, PLoS Medicine, vol.44, issue.10, 2007. ,
DOI : 10.1371/journal.pmed.0040298.sd001
Antiretroviral Therapy in Public and Private Routine Health Care Clinics in Cameroon: Lessons from the Douala Antiretroviral (DARVIR) Initiative, Clinical Infectious Diseases, vol.41, issue.1, pp.108-111, 2005. ,
DOI : 10.1086/430712
Determinants of Mortality and Nondeath Losses from an Antiretroviral Treatment Service in South Africa: Implications for Program Evaluation, Clinical Infectious Diseases, vol.43, issue.6, pp.770-776, 2006. ,
DOI : 10.1086/507095
Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi, Tropical Medicine and International Health, vol.43, issue.2, pp.464-470, 2005. ,
DOI : 10.1016/S0140-6736(02)09330-3
Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western Kenya, AIDS, vol.20, issue.1, pp.41-48, 2006. ,
DOI : 10.1097/01.aids.0000196177.65551.ea
Factors affecting attrition in a longitudinal study of patients with AIDS, AIDS Care, vol.18, issue.7, pp.821-829, 2006. ,
DOI : 10.1080/09540120500466747
Impact of Missing Data Due to Selective Dropouts in Cohort Studies and Clinical Trials, Epidemiology, vol.13, issue.3, pp.347-355, 2002. ,
DOI : 10.1097/00001648-200205000-00017
Impact of Vital Status Investigation Procedures on Estimates of Survival in Cohorts of HIV-Infected Patients From Sub-Saharan Africa, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.35, issue.3, pp.320-323, 2004. ,
DOI : 10.1097/00126334-200403010-00015
Overestimates of Survival after HAART: Implications for Global Scale-Up Efforts, PLoS ONE, vol.147, issue.3, 2008. ,
DOI : 10.1371/journal.pone.0001725.t003
Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in johannesburg, South Africa, J Acquir Immune Defic Syndr, vol.47, pp.101-107, 2008. ,
Lost to follow up: contributing factors and challenges in South African patients on antiretroviral therapy, S Afr Med J, vol.97, pp.853-857, 2007. ,
True outcomes for patients on antiretroviral therapy who are ''lost to follow-up'' in Malawi, Bull World Health Organ, vol.85, pp.550-554, 2007. ,
Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection, The American Journal of Medicine, vol.115, issue.8, pp.632-641, 2003. ,
DOI : 10.1016/j.amjmed.2003.07.007
The Cost Effectiveness of Combination Antiretroviral Therapy for HIV Disease, New England Journal of Medicine, vol.344, issue.11, pp.824-831, 2001. ,
DOI : 10.1056/NEJM200103153441108
Expanded Screening for HIV in the United States ??? An Analysis of Cost-Effectiveness, New England Journal of Medicine, vol.352, issue.6, pp.586-595, 2005. ,
DOI : 10.1056/NEJMsa042088
Use of Genotypic Resistance Testing To Guide HIV Therapy: Clinical Impact and Cost-Effectiveness, Annals of Internal Medicine, vol.134, issue.6, pp.440-450, 2001. ,
DOI : 10.7326/0003-4819-134-6-200103200-00008
Cost effectiveness in health and medicine, 1996. ,
Impact of opportunistic diseases on chronic mortality in HIV-infected adults in Cote d'Ivoire, S Afr Med J, vol.96, pp.526-529, 2006. ,
Progression to WHO criteria for starting antiretroviral therapy in a 7-year cohort of adult HIV-1 seroconverters in Abidjan, Cote d'Ivoire, Bulletin of the World Health Organization, vol.85, issue.2, pp.116-123, 2007. ,
DOI : 10.2471/BLT.06.032292
The independent effect of highly active antiretroviral therapy on severe opportunistic disease incidence and mortality in HIV-infected adults in Cote d'Ivoire, Antivir Ther, vol.12, pp.543-551, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00200067
Cost-Effectiveness of HIV Treatment in Resource-Poor Settings ??? The Case of C??te d'Ivoire, New England Journal of Medicine, vol.355, issue.11, pp.1141-1153, 2006. ,
DOI : 10.1056/NEJMsa060247
Clinical impact and cost-effectiveness of co-trimoxazole prophylaxis in patients with HIV/AIDS in C??te d???Ivoire: a trial-based analysis, AIDS, vol.19, issue.12, pp.1299-1308, 2005. ,
DOI : 10.1097/01.aids.0000180101.80888.c6
Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts, Int J Epidemiol, vol.34, pp.979-986, 2005. ,
Tolerance and Acceptability of an Efavirenz-Based Regimen in 740 Adults (Predominantly Women) in West Africa, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.42, issue.1, pp.29-35, 2006. ,
DOI : 10.1097/01.qai.0000219777.04927.50
Discontinuation of Antiretroviral Therapy in Patients with Chronic HIV Infection: Clinical, Virologic, and Immunologic Consequences, AIDS Patient Care and STDs, vol.19, issue.9, pp.550-562, 2005. ,
DOI : 10.1089/apc.2005.19.550
Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection, Annals of Internal Medicine, vol.126, issue.12, pp.946-954, 1997. ,
DOI : 10.7326/0003-4819-126-12-199706150-00003
Loss to follow-up in an international, multicentre observational study, HIV Medicine, vol.35, issue.5, pp.261-269, 2008. ,
DOI : 10.1056/NEJMoa062360
Access to care for people living with HIV/AIDS: assessing the financial burden in Côte d'Ivoire, ANRS 12137 Study, Oral Presentation, December 5, Session (SOE05); Costs of treatment and care, 15th International Conference on AIDS and STIs in Africa (ICASA), pp.3-7, 2008. ,
Nonantiretroviral Drug Consumption by CD4 Cell Count in HIV-Infected Adults, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.41, issue.2, pp.225-231, 2006. ,
DOI : 10.1097/01.qai.0000179456.39185.9b
Untangling the web of antiretroviral price reductions Available: http://www.msfaccess.org, 2008. ,
Electronic medical record systems, data quality and loss to follow-up: survey of antiretroviral therapy programmes in resource-limited settings, Bull World Health Organ, vol.86, pp.939-947, 2008. ,
Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lowerincome countries, Bull World Health Organ, vol.86, pp.559-567, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00182959
The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings, The Lancet, vol.368, issue.9534, pp.505-510, 2006. ,
DOI : 10.1016/S0140-6736(06)69158-7
Out-of-pocket costs of HAART limit HIV treatment responses in Botswana??s private sector, AIDS, vol.20, issue.9, pp.1333-1336, 2006. ,
DOI : 10.1097/01.aids.0000232245.36039.2b
Predictors of Incomplete Adherence, Virologic Failure, and Antiviral Drug Resistance among HIV-Infected Adults Receiving Antiretroviral Therapy in Tanzania, Clinical Infectious Diseases, vol.45, issue.11, pp.1492-1498, 2007. ,
DOI : 10.1086/522991
Financial barriers to HIV treatment in Yaounde, Cameroon: first results of a national cross-sectional survey, Bulletin of the World Health Organization, vol.87, issue.4, pp.279-287, 2009. ,
DOI : 10.2471/BLT.07.049643
Payment for antiretroviral drugs is associated with a higher rate of patients lost to follow-up than those offered free-of-charge therapy in Nairobi, Kenya, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.102, issue.3, pp.288-293, 2008. ,
DOI : 10.1016/j.trstmh.2007.12.007
User fees or equity funds in low-income countries, The Lancet, vol.369, issue.9555, pp.10-11, 2007. ,
DOI : 10.1016/S0140-6736(07)60008-7
[Direct cost related to management and care provision for HIV-infected children in the asymptomatic stage in Abidjan, pp.627-636, 2005. ,
Acceptance of Anti-Retroviral Therapy among Patients Infected with HIV and Tuberculosis in Rural Malawi Is Low and Associated with Cost of Transport, PLoS ONE, vol.7, issue.1, 2006. ,
DOI : 10.1371/journal.pone.0000121.t001
Low Prevalence of Detectable HIV Plasma Viremia in Patients Treated With Antiretroviral Therapy in Burkina Faso and Mali, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.48, issue.4, pp.476-484, 2008. ,
DOI : 10.1097/QAI.0b013e31817dc416
Integrating Nutrition Support for Food-Insecure Patients and Their Dependents Into an HIV Care and Treatment Program in Western Kenya, American Journal of Public Health, vol.99, issue.2, pp.215-221, 2008. ,
DOI : 10.2105/AJPH.2008.137174
High risk express care: a novel care model to reduce early mortality among high risk HIV-infected patients initiating combination antiretroviral treatment, Proceedings of the 2009 HIV/AIDS Implementer's Meeting, 2009. ,