PMID: identifiant
de la référence Pubmed : |
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 (20927359)  |
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| titre : |
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Effectiveness of chest physiotherapy in infants hospitalized with acute bronchiolitis: a multicenter, randomized, controlled trial. |
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| auteur(s) : |
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Vincent Gajdos ( ) 1, 2, Sandrine Katsahian3, 4, Nicole Beydon5, Véronique Abadie6, Loïc de Pontual7, Sophie Larrar8, Ralph Epaud9, Bertrand Chevallier10, Sylvain Bailleux1, Alix Mollet-Boudjemline1, Jean BOUYER2, Sylvie Chevret3, 4, Philippe Labrune1 |
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| résumé : |
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BACKGROUND: Acute bronchiolitis treatment in children and infants is largely supportive, but chest physiotherapy is routinely performed in some countries. In France, national guidelines recommend a specific type of physiotherapy combining the increased exhalation technique (IET) and assisted cough (AC). Our objective was to evaluate the efficacy of chest physiotherapy (IET + AC) in previously healthy infants hospitalized for a first episode of acute bronchiolitis. METHODS AND FINDINGS: We conducted a multicenter, randomized, outcome assessor-blind and parent-blind trial in seven French pediatric departments. We recruited 496 infants hospitalized for first-episode acute bronchiolitis between October 2004 and January 2008. Patients were randomly allocated to receive from physiotherapists three times a day, either IET + AC (intervention group, n=246) or nasal suction (NS, control group, n=250). Only physiotherapists were aware of the allocation group of the infant. The primary outcome was time to recovery, defined as 8 hours without oxygen supplementation associated with minimal or no chest recession, and ingesting more than two-thirds of daily food requirements. Secondary outcomes were intensive care unit admissions, artificial ventilation, antibiotic treatment, description of side effects during procedures, and parental perception of comfort. Statistical analysis was performed on an intent-to-treat basis. Median time to recovery was 2.31 days, (95% confidence interval [CI] 1.97-2.73) for the control group and 2.02 days (95% CI 1.96-2.34) for the intervention group, indicating no significant effect of physiotherapy (hazard ratio [HR]=1.09, 95% CI 0.91-1.31, p=0.33). No treatment by age interaction was found (p=0.97). Frequency of vomiting and transient respiratory destabilization was higher in the IET + AC group during the procedure (relative risk [RR]=10.2, 95% CI 1.3-78.8, p=0.005 and RR=5.4, 95% CI 1.6-18.4, p=0.002, respectively). No difference between groups in bradycardia with or without desaturation (RR=1.0, 95% CI 0.2-5.0, p=1.00 and RR=3.6, 95% CI 0.7-16.9, p=0.10, respectively) was found during the procedure. Parents reported that the procedure was more arduous in the group treated with IET (mean difference=0.88, 95% CI 0.33-1.44, p=0.002), whereas there was no difference regarding the assessment of the child's comfort between both groups (mean difference=-0.07, 95% CI -0.53 to 0.38, p=0.40). No evidence of differences between groups in intensive care admission (RR=0.7, 95% CI 0.3-1.8, p=0.62), ventilatory support (RR=2.5, 95% CI 0.5-13.0, p=0.29), and antibiotic treatment (RR=1.0, 95% CI 0.7-1.3, p=1.00) was observed. CONCLUSIONS: IET + AC had no significant effect on time to recovery in this group of hospitalized infants with bronchiolitis. Additional studies are required to explore the effect of chest physiotherapy on ambulatory populations and for infants without a history of atopy. TRIAL REGISTRATION: ClinicalTrials.gov NCT00125450. |
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| domaine : |
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Sciences du Vivant/Médecine humaine et pathologie/Pneumologie et système respiratoire
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1549-1277 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1371/journal.pmed.1000345 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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09/2010 |
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date de publication
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28/09/2010 |
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| volume : |
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7 |
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| numéro : |
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9 |
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| page, identifiant, ... : |
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e1000345 |
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| Descripteur(s) MeSH : |
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Bronchiolitis – France – Hospitalization – Humans – Infant – Respiratory Therapy – Treatment Outcome |
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| contrat, financement : |
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This work was supported by a grant from French Health Ministry (PHRC AOM 03/123) and by a grant from the Association des Réseaux Bronchiolites (ARB). |
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