Yeast Mitochondrial Interactosome Model: Metabolon Membrane Proteins Complex Involved in the Channeling of ADP/ATP.

Abstract : The existence of a mitochondrial interactosome (MI) has been currently well established in mammalian cells but the exact composition of this super-complex is not precisely known, and its organization seems to be different from that in yeast. One major difference is the absence of mitochondrial creatine kinase (MtCK) in yeast, unlike that described in the organization model of MI, especially in cardiac, skeletal muscle and brain cells. The aim of this review is to provide a detailed description of different partner proteins involved in the synergistic ADP/ATP transport across the mitochondrial membranes in the yeast Saccharomyces cerevisiae and to propose a new mitochondrial interactosome model. The ADP/ATP (Aacp) and inorganic phosphate (PiC) carriers as well as the VDAC (or mitochondrial porin) catalyze the import and export of ADP, ATP and Pi across the mitochondrial membranes. Aacp and PiC, which appear to be associated with the ATP synthase, consist of two nanomotors (F(0), F(1)) under specific conditions and form ATP synthasome. Identification and characterization of such a complex were described for the first time by Pedersen and co-workers in 2003.
Type de document :
Article dans une revue
Int J Mol Sci, 2012, 13 (2), pp.1858-85. 〈10.3390/ijms13021858〉
Liste complète des métadonnées

Littérature citée [187 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00697361
Contributeur : Sarah Hamant <>
Soumis le : mardi 8 janvier 2013 - 12:50:59
Dernière modification le : jeudi 28 septembre 2017 - 16:14:01
Document(s) archivé(s) le : vendredi 31 mars 2017 - 08:31:43

Fichier

ijms-13-01858.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

UGA

Citation

Benjamin Clémençon. Yeast Mitochondrial Interactosome Model: Metabolon Membrane Proteins Complex Involved in the Channeling of ADP/ATP.. Int J Mol Sci, 2012, 13 (2), pp.1858-85. 〈10.3390/ijms13021858〉. 〈inserm-00697361〉

Partager

Métriques

Consultations de la notice

108

Téléchargements de fichiers

182