PMID: identifiant
de la référence Pubmed : |
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 (22563085) |
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| titre : |
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Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management. |
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| auteur(s) : |
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Karina Yazdanbakhsh ( ) 1, Russell Ware2, France Noizat-Pirenne () 3, 4 |
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| laboratoire : |
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| résumé : |
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Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication. |
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| domaine : |
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Sciences du Vivant/Biochimie, Biologie Moléculaire
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0006-4971 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1182/blood-2011-11-327361 |
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| journal : |
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| Blood (Blood) |
| Publisher |
American Society of Hematology |
| ISSN |
0006-4971 (eISSN : 1528-0020) |
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| Audience : |
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internationale |
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| date de publication : |
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19/07/2012 |
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date de publication
électronique : |
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04/05/2012 |
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| volume : |
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120 |
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| numéro : |
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3 |
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| page, identifiant, ... : |
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528-37 |
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| mots-clés auteur : |
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sickle cell disease – alloimmunization – DHTR – hyperhemolysis – transfusion management – T regulatory cells (Tregs) – RH variant – rare blood groups |
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| contrat, financement : |
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This work was supported in part by National Heart, Lung, and Blood Institute grant R21HL097350 (K.Y.) and by the Etablissement Français du Sang. |
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