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Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.
Yazdanbakhsh K., Ware R. E., Noizat-Pirenne F.
Blood 120, 3 (2012) 528-37 - http://www.hal.inserm.fr/inserm-00696264
 (22563085) 
Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.
Karina Yazdanbakhsh () 1, Russell Ware2, France Noizat-Pirenne () 3, 4
1 :  Laboratory of Complement Biology
New York Blood Center
New York, NY
États-Unis
2 :  International Hematology Center of Excellence
Baylor College of Medicine
Texas Children's Center for Global Health, Houston, Texas
États-Unis
3 :  IMRB - Institut Mondor de Recherche Biomédicale
INSERM : U955 – Université Paris-Est Créteil Val-de-Marne (UPEC) – IFR10
8 rue du Général Sarrail 94010 Créteil
France
4 :  CIC - Biotherapie - CHU Henri Mondor
INSERM : CIC-BT504 – Hôpital Henri Mondor – Assistance publique - Hôpitaux de Paris (AP-HP) – Université Paris XII - Paris-Est Créteil Val-de-Marne (UPEC)
51, Avenue du Maréchal de Lattre de Tassigny 94010 Créteil cedex
France
Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.
Sciences du Vivant/Biochimie, Biologie Moléculaire
Anglais
0006-4971

Articles dans des revues avec comité de lecture
10.1182/blood-2011-11-327361
Blood (Blood)
Publisher American Society of Hematology
ISSN 0006-4971 (eISSN : 1528-0020)
internationale
19/07/2012
04/05/2012
120
3
528-37

sickle cell disease – alloimmunization – DHTR – hyperhemolysis – transfusion management – T regulatory cells (Tregs) – RH variant – rare blood groups
This work was supported in part by National Heart, Lung, and Blood Institute grant R21HL097350 (K.Y.) and by the Etablissement Français du Sang.
Liste des fichiers attachés à ce document : 
DOC
BLOOD-2010-327361_manuscript.doc(782.5 KB)
PDF
BLOOD-2010-327361_manuscript.pdf(501.1 KB)
ANNEX
Supplemental_Table_1S.docx(23.6 KB)