Dose-effect and metabolism of docosahexaenoic acid: Pathophysiological relevance in blood platelets.

Abstract : Docosahexaenoic acid (DHA) is known as a major nutrient from marine origin. Considering its beneficial effect in vascular risk prevention, the effect of DHA on blood components, especially platelets, will be reviewed here. Investigating the dose-effect of DHA in humans shows that daily intake lower than one gram/day brings several benefits, such as inhibition of platelet aggregation, resistance of monocytes against apoptosis, and reinforced antioxidant status in platelets and low-density lipoproteins. However, higher daily intake may be less efficient on those parameters, especially by losing the antioxidant effect. On the other hand, a focus on the inhibition of platelet aggregation by lipoxygenase end-products of DHA is made. The easy conversion of DHA by lipoxygenases and the formation of a double lipoxygenation product named protectin DX, reveal an original way for DHA to contribute in platelet inhibition through both the cyclooxygenase inhibition and the antagonism of thromboxane A(2) action.
keyword : lipoxygenase
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Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2012, epub ahead of print. 〈10.1016/j.plefa.2012.04.001〉
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Michel Lagarde, Catherine Calzada, Michel Guichardant, Evelyne Véricel. Dose-effect and metabolism of docosahexaenoic acid: Pathophysiological relevance in blood platelets.. Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2012, epub ahead of print. 〈10.1016/j.plefa.2012.04.001〉. 〈inserm-00691160〉

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