N. Uceyler, M. Schafers, and C. Sommer, Mode of action of cytokines on nociceptive neurons, Experimental Brain Research, vol.403, issue.Pt 3, pp.67-78, 2009.
DOI : 10.1007/s00221-009-1755-z

R. Miller, H. Jung, S. Bhangoo, and F. White, Cytokine and Chemokine Regulation of Sensory Neuron Function, Handb Exp Pharmacol, vol.194, pp.417-449, 2009.
DOI : 10.1007/978-3-540-79090-7_12

C. Abbadie, S. Bhangoo, D. Koninck, Y. Malcangio, M. Melik-parsadaniantz et al., Chemokines and pain mechanisms, Brain Research Reviews, vol.60, issue.1, pp.125-134, 2009.
DOI : 10.1016/j.brainresrev.2008.12.002

Y. Kawasaki, L. Zhang, J. Cheng, and R. Ji, Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1??, Interleukin-6, and Tumor Necrosis Factor-?? in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord, Journal of Neuroscience, vol.28, issue.20, pp.5189-5194, 2008.
DOI : 10.1523/JNEUROSCI.3338-07.2008

J. Van-steenwinckel, R. Goazigo, A. Pommier, B. Mauborgne, A. Dansereau et al., CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury, Journal of Neuroscience, vol.31, issue.15, pp.5865-5875, 2011.
DOI : 10.1523/JNEUROSCI.5986-10.2011

V. Shubayev and R. Myers, Upregulation And Interaction Of TNFalpha and Gelatinases A and B In Painful Peripheral Nerve Injury, Journal of the Peripheral Nervous System, vol.5, issue.2, pp.83-89, 2000.
DOI : 10.1046/j.1529-8027.2000.absjun-20.x

K. Komori, T. Nonaka, A. Okada, H. Kinoh, H. Hayashita-kinoh et al., Absence of mechanical allodynia and A??-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase, FEBS Letters, vol.18, issue.1-3, pp.125-128, 2004.
DOI : 10.1016/S0014-5793(03)01458-3

S. Chattopadhyay, R. Myers, J. Janes, and V. Shubayev, Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve, Brain, Behavior, and Immunity, vol.21, issue.5, pp.561-568, 2007.
DOI : 10.1016/j.bbi.2006.10.015

H. Kobayashi, S. Chattopadhyay, K. Kato, J. Dolkas, S. Kikuchi et al., MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage, Molecular and Cellular Neuroscience, vol.39, issue.4, pp.619-627, 2008.
DOI : 10.1016/j.mcn.2008.08.008

Y. Kawasaki, Z. Xu, X. Wang, J. Park, Z. Zhuang et al., Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain, Nature Medicine, vol.6, issue.3, pp.331-336, 2008.
DOI : 10.1038/nm1723

W. Liu, Y. Han, Y. Liu, A. Song, B. Barnes et al., Spinal Matrix Metalloproteinase-9 Contributes to Physical Dependence on Morphine in Mice, Journal of Neuroscience, vol.30, issue.22, pp.7613-7623, 2010.
DOI : 10.1523/JNEUROSCI.1358-10.2010

V. Joliot, C. Martinerie, G. Dambrine, G. Plassiart, M. Brisac et al., Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas., Molecular and Cellular Biology, vol.12, issue.1, pp.10-21, 1992.
DOI : 10.1128/MCB.12.1.10

C. Chen and L. Lau, Functions and mechanisms of action of CCN matricellular proteins, The International Journal of Biochemistry & Cell Biology, vol.41, issue.4, pp.771-783, 2009.
DOI : 10.1016/j.biocel.2008.07.025

C. Albrecht, H. Von-der-kammer, M. Mayhaus, J. Klaudiny, M. Schweizer et al., Muscarinic Acetylcholine Receptors Induce the Expression of the Immediate Early Growth Regulatory Gene CYR61, Journal of Biological Chemistry, vol.275, issue.37, pp.28929-28936, 2000.
DOI : 10.1074/jbc.M003053200

B. Su, W. Cai, C. Zhang, V. Martinez, A. Lombet et al., The expression of ccn3 (nov) RNA and protein in the rat central nervous system is developmentally regulated, Molecular Pathology, vol.54, issue.3, pp.184-191, 2001.
DOI : 10.1136/mp.54.3.184

S. Kocialkowski, H. Yeger, J. Kingdom, B. Perbal, and P. Schofield, Expression of the human NOV gene in first trimester fetal tissues, Anatomy and Embryology, vol.203, issue.6, pp.417-427, 2001.
DOI : 10.1007/s004290100177

H. Thibout, C. Martinerie, C. Creminon, F. Godeau, P. Boudou et al., Characterization of Human NOV in Biological Fluids: An Enzyme Immunoassay for the Quantification of Human NOV in Sera from Patients with Diseases of the Adrenal Gland and of the Nervous System, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.1, pp.327-336, 2003.
DOI : 10.1210/jc.2002-020304

L. Dreau, G. Nicot, A. Benard, M. Thibout, H. Vaudry et al., NOV/CCN3 promotes maturation of cerebellar granule neuron precursors, Molecular and Cellular Neuroscience, vol.43, issue.1, pp.60-71, 2010.
DOI : 10.1016/j.mcn.2009.02.011

C. Lin, C. Chen, S. Leu, T. Grzeszkiewicz, and L. Lau, Integrin-dependent Functions of the Angiogenic Inducer NOV (CCN3): IMPLICATION IN WOUND HEALING, Journal of Biological Chemistry, vol.280, issue.9, pp.8229-8237, 2005.
DOI : 10.1074/jbc.M404903200

M. Laurent, C. Martinerie, H. Thibout, M. Hoffman, F. Verrecchia et al., NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism, FASEB J, vol.17, pp.1919-1921, 2003.

S. Benini, B. Perbal, D. Zambelli, M. Colombo, M. Manara et al., In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type, Oncogene, vol.91, issue.27, pp.4349-4361, 2005.
DOI : 10.1038/sj.onc.1208620

M. Fukunaga-kalabis, G. Martinez, S. Telson, Z. Liu, K. Balint et al., Downregulation of CCN3 expression as a potential mechanism for melanoma progression, Oncogene, vol.60, issue.18, pp.2552-2560, 2008.
DOI : 10.1111/j.0022-202X.2005.23680.x

H. Tzeng, J. Chen, C. Tsai, C. Kuo, H. Hsu et al., CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway, Journal of Cellular Physiology, vol.19, issue.12, pp.3181-3189, 2011.
DOI : 10.1002/jcp.22672

Z. Lin, V. Natesan, H. Shi, A. Hamik, D. Kawanami et al., A novel role of CCN3 in regulating endothelial inflammation, Journal of Cell Communication and Signaling, vol.105, issue.3, pp.141-153, 2010.
DOI : 10.1007/s12079-010-0095-x

L. Kular, J. Pakradouni, P. Kitabgi, M. Laurent, and C. Martinerie, The CCN family: A new class of inflammation modulators?, Biochimie, vol.93, issue.3, pp.377-388, 2011.
DOI : 10.1016/j.biochi.2010.11.010

M. Dansereau, R. Gosselin, M. Pohl, B. Pommier, P. Mechighel et al., Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats, Journal of Neurochemistry, vol.27, issue.2, pp.757-769, 2008.
DOI : 10.1111/j.1471-4159.2008.05429.x

M. Doghman, M. Arhatte, H. Thibout, G. Rodrigues, D. Moura et al., Nephroblastoma Overexpressed/Cysteine-Rich Protein 61/Connective Tissue Growth Factor/Nephroblastoma Overexpressed Gene-3 (NOV/CCN3), a Selective Adrenocortical Cell Proapoptotic Factor, Is Down-Regulated in Childhood Adrenocortical Tumors, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.8, pp.3253-3260, 2007.
DOI : 10.1210/jc.2007-0342

URL : https://hal.archives-ouvertes.fr/hal-00172065

M. Luo, D. Zhang, S. Ma, Y. Huang, S. Shuster et al., An Efficient Intrathecal Delivery of Small Interfering RNA to the Spinal Cord and Peripheral Neurons, Molecular Pain, vol.430, p.29, 2005.
DOI : 10.1038/418244a

A. Eguchi, B. Meade, Y. Chang, C. Fredrickson, K. Willert et al., Efficient siRNA delivery into primary cells by a peptide transduction domain???dsRNA binding domain fusion protein, Nature Biotechnology, vol.72, issue.6, pp.567-571, 2009.
DOI : 10.1038/nbt.1541

S. Chaplan, F. Bach, J. Pogrel, J. Chung, and T. Yaksh, Quantitative assessment of tactile allodynia in the rat paw, Journal of Neuroscience Methods, vol.53, issue.1, pp.55-63, 1994.
DOI : 10.1016/0165-0270(94)90144-9

W. Dixon, Efficient Analysis of Experimental Observations, Annual Review of Pharmacology and Toxicology, vol.20, issue.1, pp.441-462, 1980.
DOI : 10.1146/annurev.pa.20.040180.002301

M. Pfaffl, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Research, vol.29, issue.9, p.45, 2001.
DOI : 10.1093/nar/29.9.e45

F. Lam and E. Ng, Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats, British Journal of Pharmacology, vol.351, issue.2, pp.958-969, 2010.
DOI : 10.1111/j.1476-5381.2009.00586.x

C. Liu, X. Liu, P. Crowe, G. Kelner, J. Fan et al., Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation, Gene, vol.238, issue.2, pp.471-478, 1999.
DOI : 10.1016/S0378-1119(99)00364-9

D. Calderwood, Integrin activation, Journal of Cell Science, vol.117, issue.5, pp.657-666, 2004.
DOI : 10.1242/jcs.01014

V. Raghavendra, F. Tanga, and J. Deleo, Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS, European Journal of Neuroscience, vol.45, issue.2, pp.467-473, 2004.
DOI : 10.1016/S0166-2236(00)01854-3

G. Rosenberg, Matrix metalloproteinases in neuroinflammation, Glia, vol.2, issue.3, pp.279-291, 2002.
DOI : 10.1002/glia.10108

C. Chen, J. Young, R. Monzon, N. Chen, V. Todorovic et al., Cytotoxicity of TNF?? is regulated by integrin-mediated matrix signaling, The EMBO Journal, vol.13, issue.5, pp.1257-1267, 2007.
DOI : 10.1038/sj.emboj.7601596

C. Chen and L. Lau, Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines, Journal of Cell Communication and Signaling, vol.159, issue.1, pp.63-69, 2010.
DOI : 10.1007/s12079-009-0080-4

R. Hynes, Integrins, Cell, vol.110, issue.6, pp.673-687, 2002.
DOI : 10.1016/S0092-8674(02)00971-6

O. Dina, C. Parada, J. Yeh, X. Chen, G. Mccarter et al., Integrin signaling in inflammatory and neuropathic pain in the rat, European Journal of Neuroscience, vol.4, issue.3, pp.634-642, 2004.
DOI : 10.1074/jbc.M102436200

W. Fu, T. Chang, W. Sun, Q. Ling, H. Peng et al., Inhibition of neuropathic pain by a potent disintegrin???triflavin, Neuroscience Letters, vol.368, issue.3, pp.263-268, 2004.
DOI : 10.1016/j.neulet.2004.06.035

M. Tsuda, E. Toyomitsu, T. Komatsu, T. Masuda, E. Kunifusa et al., Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury, Glia, vol.12, issue.5, pp.579-585, 2008.
DOI : 10.1002/glia.20641

M. Lemons and M. Condic, Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1, Experimental Neurology, vol.202, issue.2
DOI : 10.1016/j.expneurol.2006.06.008

M. Lemons and M. Condic, Integrin signaling is integral to regeneration, Experimental Neurology, vol.209, issue.2, pp.343-352, 2008.
DOI : 10.1016/j.expneurol.2007.05.027

O. Dina, T. Hucho, J. Yeh, M. Malik-hall, D. Reichling et al., Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia, Pain, vol.115, issue.1, pp.191-203, 2005.
DOI : 10.1016/j.pain.2005.02.028

T. Shimoyama, S. Hiraoka, M. Takemoto, M. Koshizaka, H. Tokuyama et al., CCN3 Inhibits Neointimal Hyperplasia Through Modulation of Smooth Muscle Cell Growth and Migration, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.30, issue.4, pp.3675-682, 2010.
DOI : 10.1161/ATVBAHA.110.203356

M. Narita, M. Shimamura, S. Imai, C. Kubota, Y. Yajima et al., Role of interleukin-1?? and tumor necrosis factor-??-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice, Neuroscience, vol.152, issue.2, pp.477-486, 2008.
DOI : 10.1016/j.neuroscience.2007.10.039

Y. Gao, L. Zhang, O. Samad, M. Suter, K. Yasuhiko et al., JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain, Journal of Neuroscience, vol.29, issue.13, pp.4096-4108, 2009.
DOI : 10.1523/JNEUROSCI.3623-08.2009

Y. Nagakura, M. Okada, A. Kohara, T. Kiso, T. Toya et al., Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics, Journal of Pharmacology and Experimental Therapeutics, vol.306, issue.2, pp.490-497, 2003.
DOI : 10.1124/jpet.103.050781

R. Bertorelli, L. Corradini, K. Rafiq, J. Tupper, G. Calo et al., exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain, British Journal of Pharmacology, vol.224, issue.2, pp.1252-1258, 1999.
DOI : 10.1038/sj.bjp.0702884

G. Burgess, M. Perkins, H. Rang, E. Campbell, M. Brown et al., bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia, British Journal of Pharmacology, vol.102, issue.1, pp.77-86, 2000.
DOI : 10.1038/sj.bjp.0703012

Y. Gao, Z. Xu, Y. Liu, Y. Wen, I. Decosterd et al., The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition, Pain, vol.148, issue.2, pp.309-319, 2010.
DOI : 10.1016/j.pain.2009.11.017

H. Schaible, M. Schmelz, and I. Tegeder, Pathophysiology and treatment of pain in joint disease???, Advanced Drug Delivery Reviews, vol.58, issue.2, pp.323-342, 2006.
DOI : 10.1016/j.addr.2006.01.011

R. Dev, P. Srivastava, J. Iyer, S. Dastidar, and A. Ray, Therapeutic potential of matrix metalloprotease inhibitors in neuropathic pain, Expert Opinion on Investigational Drugs, vol.23, issue.34, pp.455-468, 2010.
DOI : 10.1007/978-1-59259-125-1