PMID: identifiant
de la référence Pubmed : |
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 (21813793)  |
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| titre : |
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Socioeconomic differences in cardiometabolic factors: social causation or health-related selection? Evidence from the Whitehall II Cohort Study, 1991-2004. |
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| auteur(s) : |
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Marko Elovainio ( ) 1, 2, Jane Ferrie1, Archana Singh-Manoux1, 3, Martin Shipley1, G David Batty1, Jenny Head1, Mark Hamer1, Markus Jokela1, 4, Marianna Virtanen1, 5, Eric Brunner1, Michael Marmot1, Mika Kivimäki1 |
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| laboratoire : |
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| titre abrégé : |
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Social Causation or Health Selection |
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| résumé : |
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In this study, the health-related selection hypothesis (that health predicts social mobility) and the social causation hypothesis (that socioeconomic status influences health) were tested in relation to cardiometabolic factors. The authors screened 8,312 United Kingdom men and women 3 times over 10 years between 1991 and 2004 for waist circumference, body mass index, systolic and diastolic blood pressure, fasting glucose, fasting insulin, serum lipids, C-reactive protein, and interleukin-6; identified participants with the metabolic syndrome; and measured childhood health retrospectively. Health-related selection was examined in 2 ways: 1) childhood health problems as predictors of adult occupational position and 2) adult cardiometabolic factors as predictors of subsequent promotion at work. Social causation was assessed using adult occupational position as a predictor of subsequent change in cardiometabolic factors. Hospitalization during childhood and lower birth weight were associated with lower occupational position (both P's ≤ 0.002). Cardiometabolic factors in adulthood did not consistently predict promotion. In contrast, lower adult occupational position predicted adverse changes in several cardiometabolic factors (waist circumference, body mass index, fasting glucose, and fasting insulin) and an increased risk of new-onset metabolic syndrome (all P's ≤ 0.008). These findings suggest that health-related selection operates at younger ages and that social causation contributes to socioeconomic differences in cardiometabolic health in midlife. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0002-9262 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1093/aje/kwr149 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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01/10/2011 |
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date de publication
électronique : |
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03/08/2011 |
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| volume : |
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174 |
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| numéro : |
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7 |
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| page, identifiant, ... : |
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779-89 |
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| Descripteur(s) MeSH : |
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Adult – Aged – Cardiovascular Diseases – Causality – Child – Cohort Studies – Employment – Female – Great Britain – Health Status Disparities – Humans – Infant – Low Birth Weight – Newborn – Lipoproteins – LDL – Logistic Models – Male – Metabolic Syndrome X – Middle Aged – Risk Factors – Social Class – Socioeconomic Factors – Adult |
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| contrat, financement : |
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The Whitehall II study has been supported by grants from the Medical Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart Lung and Blood Institute (HL36310), US, NIH: National Institute on Aging (AG13196, R01 AG034454), US, NIH; Agency for Health Care Policy Research (HS06516); and the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health. ME is supported by Work Environment Fund and the Academy of Finland (Grant number 128002). MK is supported by the BUPA Foundation, the Academy of Finland and the EU New OSH ERA Research Programme Grant; GDB is a Wellcome Trust Research Fellow; AS-M is supported by a 'EURYI' award from the European Science Foundation; JEF is supported by the Medical Research Council; MJS and MH are supported by the British Heart Foundation; and MGM is supported by a MRC Research Professorship. |
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