A. Borin and O. L. Cruz, Study of distortion-product otoacoustic emissions during hypothermia in humans, Brazilian Journal of Otorhinolaryngology, vol.74, issue.3, pp.401-409, 2008.
DOI : 10.1016/S1808-8694(15)30575-9

P. Carpentier, I. S. Delamanche, M. Le-bert, G. Blanchet, and C. Bouchaud, Seizure-related opening of the blood?brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats, Neurotoxicology, vol.3, pp.493-508, 1990.

P. Carpentier, A. Foquin-tarricone, N. Bodjarian, G. Rondouin, M. Lerner-natoli et al., Anticonvulsant and antilethal effects of the phencyclidine derivate TCP in soman poisoning, Neurotoxicology, vol.15, pp.837-852, 1994.

P. Carpentier, A. Foquin, G. Rondouin, M. Lerner-natoli, D. M. Degroot et al., Effects of atropine sulphate on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neuropathology, Neurotoxicology, vol.4, pp.521-540, 2000.

P. Carpentier, G. Testylier, V. Baille, F. Dhote, A. Job et al., Soman-induced seizures and related brain damage: how to treat seizures and assess their effects noninvasively?, J. Med. C.B.R. Def, vol.6, 2008.

G. E. Cassel and P. Fosbraey, Measurement of the oxime HI-6 after peripheral administration in tandem with neurotransmitter levels in striatal dialysates: Effects of soman intoxication, Journal of Pharmacological and Toxicological Methods, vol.35, issue.3, pp.159-166, 1996.
DOI : 10.1016/1056-8719(96)00027-5

J. G. Clement, Pharmacological nature of soman-induced hypothermia in mice, Pharmacology Biochemistry and Behavior, vol.44, issue.3, pp.689-702, 1993.
DOI : 10.1016/0091-3057(93)90187-X

J. G. Clement and B. Broxup, Efficacy of diazepam and avizafone against somaninduced neuropathology in brain of rats, Neurotoxicology, vol.14, pp.485-504, 1993.

G. L. Ellman, K. D. Courney, V. Andres, and R. M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochemical Pharmacology, vol.7, issue.2, pp.88-95, 1961.
DOI : 10.1016/0006-2952(61)90145-9

T. F. Elsmore, Circadian susceptibility to soman poisoning, Fundam. Appl. Toxicol, vol.2, pp.238-241, 1981.

E. Emmerich, F. Richter, V. Linss, and W. Linss, Frequency-specific cochlear damage in guinea pig after exposure to different types of realistic industrial noise, Hearing Research, vol.201, issue.1-2, pp.1-2, 2005.
DOI : 10.1016/j.heares.2004.09.009

F. P. Harris, Distortion-Product Otoacoustic Emissions in Humans with High Frequency Sensorineural Hearing Loss, Journal of Speech Language and Hearing Research, vol.33, issue.3, pp.594-600, 1990.
DOI : 10.1044/jshr.3303.594

V. R. Jimmerson, T. M. Shih, and R. B. Mailman, Variability in soman toxicity in the rat: Correlation with biochemical and behavioral measures, Toxicology, vol.57, issue.3, pp.241-254, 1989.
DOI : 10.1016/0300-483X(89)90114-5

A. Job and J. Nottet, DPOAEs in young normal-hearing subjects with histories of otitis media: evidence of sub-clinical impairments, Hearing Research, vol.167, issue.1-2, pp.1-2, 2002.
DOI : 10.1016/S0378-5955(02)00330-1

A. Job, C. Cian, D. Esquivié, D. Leifflen, M. Trousselard et al., Moderate variations of mood/emotional states related to alterations in cochlear otoacoustic emissions and tinnitus onset in young normal hearing subjects exposed to gun impulse noise, Hearing Research, vol.193, issue.1-2, pp.31-38, 2004.
DOI : 10.1016/j.heares.2004.02.010

A. Job, V. Baille, F. Dorandeu, B. Pouyatos, A. Foquin et al., Distortion product otoacoustic emissions as non-invasive biomarkers and predictors of soman-induced central neurotoxicity: A preliminary study, Toxicology, vol.238, issue.2-3, pp.119-129, 2007.
DOI : 10.1016/j.tox.2007.05.024

A. Job, M. Raynal, M. Kossowski, M. Studler, C. Ghernaouti et al., Otoacoustic detection of risk of early hearing loss in ears with normal audiograms: A 3-year follow-up study, Hearing Research, vol.251, issue.1-2, pp.10-16, 2009.
DOI : 10.1016/j.heares.2009.02.008

J. Kassa and J. Fusek, The positive influence of a cholinergic???anticholinergic pretreatment and antidotal treatment on rats poisoned with supralethal doses of soman, Toxicology, vol.128, issue.1, pp.1-7, 1998.
DOI : 10.1016/S0300-483X(97)00186-8

J. Kassa and J. Fusek, The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats, Toxicology, vol.154, issue.1-3, pp.67-73, 2000.
DOI : 10.1016/S0300-483X(00)00322-X

D. T. Kemp, S. Ryan, and P. Bray, A Guide to the Effective Use of Otoacoustic Emissions, Ear and Hearing, vol.11, issue.2, pp.93-105, 1990.
DOI : 10.1097/00003446-199004000-00004

G. Lallement, F. Renault, D. Baubichon, M. Peoc-'h, M. F. Burckhart et al., Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics, Arch. Toxicol, vol.74, pp.480-486, 2000.

G. Lallement, C. Masqueliez, D. Baubichon, N. Cassegrain, P. Renaudeau et al., Protection against soman-induced lethality of the antidote combination atropine?pralidoxime?pro-diazepam packaged as a freeze-dried form, J. Med. C.B.R, vol.4, issue.4, 2004.

G. Lallement, D. Clarenç-on, G. Brochier, D. Baubichon, M. Galonnier et al., Efficacy of Atropine/Pralidoxime/Diazepam or Atropine/HI-6/Prodiazepam in Primates Intoxicated by Soman, Pharmacology Biochemistry and Behavior, vol.56, issue.2, pp.325-332, 1997.
DOI : 10.1016/S0091-3057(96)00292-4

R. Lataye, P. Campo, B. Pouyatos, B. Cossec, V. Blachere et al., Solvent ototoxicity in the rat and guinea pig, Neurotoxicology and Teratology, vol.25, issue.1, pp.39-50, 2003.
DOI : 10.1016/S0892-0362(02)00326-4

M. Lotti, Cholinesterase inhibition: complexities in interpretation, Clin. Chem, vol.12, issue.2, pp.1814-1818, 1995.

M. P. Maidment and D. G. Upshall, Pharmacokinetics of the conversion of a peptido-aminobenzophenone pro-drug of diazepam in guinea-pig and rhesus monkeys, J. Biopharm. Sci, vol.1, pp.19-32, 1990.

M. Jr, J. H. Jaax, N. K. Crowley, R. A. Mays, M. Z. Modrow et al., Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology, Fundam. Appl. Toxicol, vol.2, pp.256-276, 1989.

J. H. Mcdonough and T. Shih, Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology, Neurosci. Biobehav. Rev, vol.5, pp.559-579, 1997.

C. D. Mills, B. M. Loos, and C. M. Henley, Increased susceptibility of male rats to kanamycin-induced cochleotoxicity, Hearing Research, vol.128, issue.1-2, pp.1-2, 1999.
DOI : 10.1016/S0378-5955(98)00190-7

T. Myhrer, S. Enger, and P. Aas, Efficacy of Immediate and Subsequent Therapies against Soman-Induced Seizures and Lethality in Rats, Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology, vol.72, issue.2, pp.184-191, 2006.
DOI : 10.1016/0041-008X(92)90366-Z

J. C. Neill, Z. Liu, M. Mikati, and G. L. Holmes, Pilocarpine seizures cause agedependent impairment in auditory location discrimination, J. Exp. Anal. Behav, vol.3, pp.357-370, 2005.

G. Paludetti, D. Nardo, W. Ecclesia, A. Evoli, A. Scarano et al., The role of cholinergic transmission in outer hair cell functioning evaluated by distortion product otoacoustic emissions in myasthenic patients, Acta Oto-Laryngol, vol.2, pp.119-121, 2001.

G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, second edition, 1986.

B. Pouyatos, C. A. Gearhart, and L. D. Fechter, Acrylonitrile potentiates hearing loss and cochlear damage induced by moderate noise exposure in rats, Toxicology and Applied Pharmacology, vol.204, issue.1, pp.46-56, 2005.
DOI : 10.1016/j.taap.2004.08.015

J. Puel, J. Ruel, M. Guitton, J. Wang, and R. Pujol, The Inner Hair Cell Synaptic Complex: Physiology, Pharmacology and New Therapeutic Strategies, Audiology and Neurotology, vol.7, issue.1, pp.49-54, 2002.
DOI : 10.1159/000046864

R. Pujol, M. Lenoir, D. Robertson, M. Eybalin, and B. M. Johnstone, Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells, Hearing Research, vol.18, issue.2, pp.145-151, 1985.
DOI : 10.1016/0378-5955(85)90006-1

R. Pujol, M. Eybalin, and M. Lenoir, Synaptology of the cochlea: different types of synapse, presumptive neurotransmitters, physiopathological implications Applied and basic aspects of noise-induced hearing loss, pp.43-53, 1986.

D. L. Rickett, J. F. Glenn, and E. T. Beers, Central respiratory effects versus neuromuscular actions of nerve agents, Neurotoxicology, vol.7, pp.225-236, 1986.

L. Taysse, J. H. Calvet, J. Buée, D. Christin, S. Delamanche et al., Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: Influence of atropine dose, Toxicology, vol.188, issue.2-3, pp.197-209, 2003.
DOI : 10.1016/S0300-483X(03)00086-6

L. Taysse, S. Daulon, S. Delamanche, B. Bellier, and P. Breton, Protection against soman-induced neuropathology and respiratory failure: A comparison of the efficacy of diazepam and avizafone in guinea pig, Toxicology, vol.225, issue.1, pp.25-35, 2006.
DOI : 10.1016/j.tox.2006.04.043

G. Testylier, H. Lahrech, O. Montignon, A. Foquin, C. Delacour et al., Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology, Toxicology and Applied Pharmacology, vol.220, issue.2, pp.125-137, 2007.
DOI : 10.1016/j.taap.2007.01.013

URL : https://hal.archives-ouvertes.fr/inserm-00381761

D. G. Upshall, S. J. Gouldstone, N. Macey, M. P. Maidment, S. J. Wast et al., Conversion of a peptide-aminobenzophenone pro-drug to diazepam in vitro, enzyme isolation and characterization, J. Biopharm. Sci, vol.1, pp.111-126, 1990.

J. F. Young, B. J. Gough, R. L. Suber, and D. W. Gaylor, CORRELATION OF BLOOD CHOLINESTERASE LEVELS WITH TOXICITY OF SARIN IN RATS, Journal of Toxicology and Environmental Health, Part A, vol.62, issue.3, pp.161-174, 2001.
DOI : 10.1080/009841001458280