Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet, Blood, vol.115, issue.3, pp.453-74, 2010. ,
DOI : 10.1182/blood-2009-07-235358
Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review, British Journal of Haematology, vol.61, issue.5, pp.387-400, 2007. ,
DOI : 10.1038/sj.bmt.1705169
The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties, Blood, vol.92, pp.2322-2355, 1998. ,
Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype, Journal of Clinical Oncology, vol.26, issue.29, pp.4791-4798, 2008. ,
DOI : 10.1200/JCO.2008.16.0259
Identification of PML/RAR?? rearrangements in suspected acute promyelocytic leukemia using fluorescence in situ hybridization of bone marrow smears: a comparison with cytogenetics and RT-PCR in MRC ATRA trial patients, Leukemia, vol.14, issue.5, pp.950-953, 2000. ,
DOI : 10.1038/sj.leu.2401688
Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action " Molecular Cytogenetic Diagnosis in Haematological Malignancies, Blood, vol.96, pp.1297-308, 2000. ,
Comparison of karyotype analysis and RT-PCR for AML1/ETO in 204 unselected patients with AML, Annals of Hematology, vol.76, issue.3-4, pp.139-182, 1998. ,
DOI : 10.1007/s002770050378
Cytogenetically cryptic AML1-ETO and CBF beta-MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukaemia, Br J Haematol, vol.111, pp.1051-1057, 2000. ,
Comparison of Cytogenetic and Molecular Genetic Detection of t(8;21) and inv(16) in a Prospective Series of Adults With De Novo Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study, Journal of Clinical Oncology, vol.19, issue.9, pp.2482-92, 2001. ,
DOI : 10.1200/JCO.2001.19.9.2482
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling, Haematologica, vol.94, issue.1, pp.131-135, 2009. ,
DOI : 10.3324/haematol.13299
Prognostically Useful Gene-Expression Profiles in Acute Myeloid Leukemia, New England Journal of Medicine, vol.350, issue.16, pp.1617-1645, 2004. ,
DOI : 10.1056/NEJMoa040465
Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia, New England Journal of Medicine, vol.350, issue.16, pp.1605-1621, 2004. ,
DOI : 10.1056/NEJMoa031046
Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group, Journal of Clinical Oncology, vol.28, issue.15, pp.2529-2566, 2010. ,
DOI : 10.1200/JCO.2009.23.4732
Global approach to the diagnosis of leukemia using gene expression profiling, Blood, vol.106, issue.4, pp.1189-98, 2005. ,
DOI : 10.1182/blood-2004-12-4938
Acute myeloid leukemias with de la Blétière et al. BMC6 reciprocal rearrangements can be distinguished by specific gene expression profiles, Medical Genomics Proc Natl Acad Sci, vol.5, issue.99, pp.10008-10021, 2002. ,
Molecular characterization of acute leukemias by use of microarray technology, Genes, Chromosomes and Cancer, vol.99, issue.4, pp.396-405, 2003. ,
DOI : 10.1002/gcc.10225
Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia, Leukemia, vol.19, issue.3, pp.402-411, 2005. ,
DOI : 10.1038/sj.leu.2403625
Gene expression profiling of pediatric acute myelogenous leukemia, Blood, vol.104, issue.12, pp.3679-87, 2004. ,
DOI : 10.1182/blood-2004-03-1154
Standardization and quality control studies of ???real-time??? quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia ??? A Europe Against Cancer Program, Leukemia, vol.17, issue.12, pp.2318-57, 2003. ,
DOI : 10.1038/sj.leu.2403135
Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype, Blood, vol.106, issue.10, pp.3618-3638, 2005. ,
DOI : 10.1182/blood-2005-05-2174
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia, Leukemia, vol.10, pp.1911-1919, 1996. ,
Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia, British Journal of Haematology, vol.79, issue.4, pp.983-991, 2001. ,
DOI : 10.1038/sj.leu.2400812
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia, Nature Genetics, vol.27, issue.3, pp.263-70, 2001. ,
DOI : 10.1038/85820
The grouping genetic algorithm In Genetic Algorithms and Grouping Problems.. First edition, pp.81-110, 1998. ,
Purity for clarity: the need for purification of tumor cells in DNA microarray studies, Leukemia, vol.114, pp.618-645, 2005. ,
DOI : 10.1073/pnas.2536479100
Theoretical and experimental comparisons of gene expression indexes for oligonucleotide arrays, Bioinformatics, vol.18, issue.11, pp.1470-1476, 2002. ,
DOI : 10.1093/bioinformatics/18.11.1470
Summaries of Affymetrix GeneChip probe level data, Nucleic Acids Research, vol.31, issue.4, pp.31-46, 2003. ,
DOI : 10.1093/nar/gng015
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias, Leukemia, vol.17, issue.9, pp.2000-2009, 2007. ,
DOI : 10.1038/nrc1885
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance, Blood, vol.106, issue.12, pp.3747-54, 2005. ,
DOI : 10.1182/blood-2005-05-2168
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance, Blood, vol.106, issue.3, pp.899-902, 2005. ,
DOI : 10.1182/blood-2005-02-0560
Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways, Leukemia, vol.36, issue.6, pp.1216-1236, 2010. ,
DOI : 10.1038/ng.295
A validated diagnostic microarray for newly diagnosed adult AML patients, Oral Communication at European Hematology Association annual meeting, 2011. ,
Pattern robustness of diagnostic gene expression signatures in leukemia, Genes, Chromosomes and Cancer, vol.1, issue.3, pp.299-307, 2005. ,
DOI : 10.1002/gcc.20126
Impact of RNA degradation on gene expression profiling, BMC Medical Genomics, vol.88, issue.4, p.36, 2010. ,
DOI : 10.1038/labinvest.2008.11