Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.

Abstract : BACKGROUND: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. CASE PRESENTATION: We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection. CONCLUSIONS: Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
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BMC Infectious Diseases, BioMed Central, 2009, 9 (1), pp.200. 〈10.1186/1471-2334-9-200〉
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Denis Malvy, Khaled Ezzedine, Maria Mamani-Matsuda, Brigitte Autran, Hugues Tolou, et al.. Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.. BMC Infectious Diseases, BioMed Central, 2009, 9 (1), pp.200. 〈10.1186/1471-2334-9-200〉. 〈inserm-00668479〉

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