L. Buée, T. Bussière, V. Buée-scherrer, A. Delacourte, and P. Hof, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work., Brain Research Reviews, vol.33, issue.1, pp.95-130, 2000.
DOI : 10.1016/S0165-0173(00)00019-9

S. Schraen-maschke, N. Sergeant, and C. Dhaenens, Tau as a biomarker of neurodegenerative diseases, Biomarkers in Medicine, vol.2, issue.4, pp.363-384, 2008.
DOI : 10.2217/17520363.2.4.363

URL : https://hal.archives-ouvertes.fr/inserm-00375314

A. Gómez-ramos, M. Díaz-hernández, R. Cuadros, F. Hernández, and J. Avila, Extracellular tau is toxic to neuronal cells, FEBS Letters, vol.84, issue.20, pp.4842-50, 2006.
DOI : 10.1016/j.febslet.2006.07.078

B. Frost, R. Jacks, and M. Diamond, Propagation of Tau Misfolding from the Outside to the Inside of a Cell, Journal of Biological Chemistry, vol.284, issue.19, pp.12845-52, 2009.
DOI : 10.1074/jbc.M808759200

F. Clavaguera, T. Bolmont, and R. Crowther, Transmission and spreading of tauopathy in transgenic mouse brain, Nature Cell Biology, vol.8, issue.7, pp.909-922, 2009.
DOI : 10.1038/ncb1901

D. Schenk, R. Barbour, and W. Dunn, Immunization with amyloid-beta attenuates Alzheimerdisease-like pathology in the PDAPP mouse, Nature, vol.400, issue.6740, pp.173-180, 1999.
DOI : 10.1038/22124

D. Brody and D. Holtzman, Active and Passive Immunotherapy for Neurodegenerative Disorders, Annual Review of Neuroscience, vol.31, issue.1
DOI : 10.1146/annurev.neuro.31.060407.125529

T. Wisniewski and A. Boutajangout, Vaccination as a Therapeutic Approach to Alzheimer's Disease, Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, vol.169, issue.1, pp.17-31, 2010.
DOI : 10.1002/msj.20156

D. Gillis, N. Yetiv, and M. Gdalevich, Active versus passive immunization against hepatitis A in the Israel defence forces: a cost???benefit analysis, Vaccine, vol.18, issue.26, pp.3005-3015, 2000.
DOI : 10.1016/S0264-410X(00)00091-8

A. Asuni, A. Boutajangout, A. Quatermain, and E. Sigurdsson, Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements, Journal of Neuroscience, vol.27, issue.34, pp.9115-9144, 2007.
DOI : 10.1523/JNEUROSCI.2361-07.2007

M. Boimel, N. Grigoriadis, A. Lourbopoulos, E. Haber, O. Abramsky et al., Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice, Experimental Neurology, vol.224, issue.2, pp.472-85, 2010.
DOI : 10.1016/j.expneurol.2010.05.010

A. Boutajangout, D. Quartermain, and E. Sigurdsson, Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model, Journal of Neuroscience, vol.30, issue.49, pp.16559-66, 2010.
DOI : 10.1523/JNEUROSCI.4363-10.2010

A. Boutajangout, J. Ingadottir, P. Davies, and E. Sigurdsson, Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain, Journal of Neurochemistry, vol.18, issue.4, pp.658-67, 2011.
DOI : 10.1111/j.1471-4159.2011.07337.x

H. Rosenmann, N. Grigoriadis, and D. Karussis, Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein, Archives of Neurology, vol.63, issue.10, pp.1459-67, 2006.
DOI : 10.1001/archneur.63.10.1459

M. Hasegawa, R. Jakes, R. Crowther, V. Lee, Y. Ihara et al., Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein, FEBS Letters, vol.87, issue.1, pp.25-30, 1996.
DOI : 10.1016/0014-5793(96)00271-2

T. Bussière, P. Hof, and C. Mailliot, Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration, Acta Neuropathologica, vol.97, issue.3, pp.221-251, 1999.
DOI : 10.1007/s004010050978

J. Augustinack, A. Schneider, E. Mandelkow, and B. Hyman, Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease, Acta Neuropathologica, vol.103, issue.1, pp.26-35, 2002.
DOI : 10.1007/s004010100423

N. Sahara, J. Lewis, and M. Deture, Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility, Journal of Neurochemistry, vol.150, issue.6, pp.1498-508, 2002.
DOI : 10.1046/j.1471-4159.2002.01241.x

B. Allen, E. Ingram, and M. Takao, Abundant Tau filaments and nonapoptotic neurodegeneration in transgenic mide expressing human P301S Tau protein, J Neurosci, vol.22, pp.9340-51, 2002.

K. Schindowski, A. Bretteville, and K. Leroy, Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits, The American Journal of Pathology, vol.169, issue.2, pp.599-616, 2006.
DOI : 10.2353/ajpath.2006.060002

K. Belarbi, S. Burnouf, and F. Fernandez-gomez, Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology, Neurobiology of Disease, vol.43, issue.2, 2011.
DOI : 10.1016/j.nbd.2011.04.022

A. Van-der-jeugd, T. Ahmed, and S. Burnouf, Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission, Neurobiology of Learning and Memory, vol.95, issue.3, pp.296-304, 2011.
DOI : 10.1016/j.nlm.2010.12.005

K. Green, L. Billings, B. Roozendaal, J. Mcgaugh, and F. Laferla, Glucocorticoids Increase Amyloid-beta and Tau Pathology in a Mouse Model of Alzheimer's Disease, Journal of Neuroscience, vol.26, issue.35, pp.9047-9056, 2006.
DOI : 10.1523/JNEUROSCI.2797-06.2006

V. Buée-scherrer and M. Goedert, Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells, FEBS Letters, vol.79, issue.1-3, pp.151-154, 2002.
DOI : 10.1016/S0014-5793(02)02460-2

M. Caillet-boudin and A. Delacourte, Induction of a specific tau Alzheimer epitope in SY-5Y neuroblastoma cells, NeuroReport, vol.8, issue.1, pp.307-317, 1996.
DOI : 10.1097/00001756-199612200-00061

M. Yanagisawa, E. Planel, K. Ishiguro, and S. Fujita, Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease, FEBS Letters, vol.777, issue.3, pp.329-362, 1999.
DOI : 10.1016/S0014-5793(99)01480-5

N. Deters, L. Ittner, and J. Götz, Divergent phosphorylation pattern of tau in P301L tau transgenic mice, European Journal of Neuroscience, vol.18, issue.1, pp.137-184, 2008.
DOI : 10.1111/j.1460-9568.2008.06318.x

I. Ferrer, I. Hernández, and B. Puig, Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy, Journal of Alzheimer's Disease, vol.5, issue.6, pp.445-54, 2003.
DOI : 10.3233/JAD-2003-5604

I. Ferrer, I. Hernández, and M. Boada, Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies, Acta Neuropathologica, vol.106, issue.5, pp.419-454, 2003.
DOI : 10.1007/s00401-003-0756-4

J. Götz, F. Chen, J. Van-dorpe, and R. Nitsch, Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Abeta 42 Fibrils, Science, vol.293, issue.5534, pp.1491-1496, 2001.
DOI : 10.1126/science.1062097

Q. Ma, F. Yang, and E. Rosario, ??-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin, Journal of Neuroscience, vol.29, issue.28, pp.9078-89, 2009.
DOI : 10.1523/JNEUROSCI.1071-09.2009

F. Grueninger, B. Bohrmann, and C. Czech, Phosphorylation of Tau at S422 is enhanced by A?? in TauPS2APP triple transgenic mice, Neurobiology of Disease, vol.37, issue.2, pp.294-306, 2010.
DOI : 10.1016/j.nbd.2009.09.004

A. Sas, R. Jones, and W. Tyor, Intra-peritoneal Injection of Polyclonal Anti-Interferon Alpha Antibodies Cross the Blood Brain Barrier and Neutralize Interferon Alpha, Neurochemical Research, vol.6, issue.11, pp.2281-2288, 2008.
DOI : 10.1007/s11064-008-9715-8

M. Patel, B. Goyal, S. Bhadada, J. Bhatt, and A. Amin, Getting into the Brain, CNS Drugs, vol.45, issue.1, pp.35-58, 2009.
DOI : 10.2165/0023210-200923010-00003

E. Sigurdsson, Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies, Journal of Alzheimer's Disease, vol.15, issue.2, pp.157-68, 2008.
DOI : 10.3233/JAD-2008-15202

A. Guillozet-bongaarts, M. Cahill, V. Cryns, M. Reynolds, R. Berry et al., Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo, Journal of Neurochemistry, vol.69, issue.4, pp.1005-1019, 2006.
DOI : 10.1073/pnas.96.4.1391

H. Yin and J. Kuret, C-terminal truncation modulates both nucleation and extension phases of ?? fibrillization, FEBS Letters, vol.336, issue.1, pp.211-216, 2006.
DOI : 10.1016/j.febslet.2005.11.077

K. Leroy, A. Bretteville, and K. Schindowski, Early Axonopathy Preceding Neurofibrillary Tangles in Mutant Tau Transgenic Mice, The American Journal of Pathology, vol.171, issue.3, pp.976-92, 2007.
DOI : 10.2353/ajpath.2007.070345

D. Morgan, Mechanisms of A?? Plaque Clearance following Passive A?? Immunization, Neurodegenerative Diseases, vol.2, issue.5, pp.261-267, 2005.
DOI : 10.1159/000090366

T. Wisniewski and E. Sigurdsson, Murine models of Alzheimer's disease and their use in developing immunotherapies, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1802, issue.10, pp.847-59, 2010.
DOI : 10.1016/j.bbadis.2010.05.004

M. Ramsden, L. Kotilinek, C. Forster, J. Paulson, E. Mcgowan et al., Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L), Journal of Neuroscience, vol.25, issue.46, pp.10637-10684, 2005.
DOI : 10.1523/JNEUROSCI.3279-05.2005

C. Andorfer, C. Acker, Y. Kress, P. Hof, K. Duff et al., Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms, Journal of Neuroscience, vol.25, issue.22, pp.5446-54, 2005.
DOI : 10.1523/JNEUROSCI.4637-04.2005

M. Polydoro, C. Acker, K. Duff, P. Castillo, and P. Davies, Age-dependent impairment of cognitive and synaptic function in transgenic mouse model of tau pathology (htau mouse), Alzheimer's & Dementia, vol.5, issue.4, pp.10741-10750, 2009.
DOI : 10.1016/j.jalz.2009.05.531

X. Chai, S. Wu, T. Murray, R. Kinley, C. Cella et al., Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models: REDUCTION OF TAU PATHOLOGY AND DELAY OF DISEASE PROGRESSION, Journal of Biological Chemistry, vol.286, issue.39, pp.34457-67, 2011.
DOI : 10.1074/jbc.M111.229633

C. Lasagna-reeves, D. Castillo-carranza, G. Jackson, and R. Kayed, Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies, Current Alzheimer Research, vol.8, issue.6, pp.659-65, 2011.
DOI : 10.2174/156720511796717177

A. Boutajangout, E. Sigurdsson, and P. Krishnamurthy, Tau as a Therapeutic Target for Alzheimers Disease, Current Alzheimer Research, vol.8, issue.6, pp.666-77, 2011.
DOI : 10.2174/156720511796717195

E. Matsuo, R. Shin, and M. Billingsley, Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau, Neuron, vol.13, issue.4, pp.989-1002, 1994.
DOI : 10.1016/0896-6273(94)90264-X

G. Jicha, E. Lane, I. Vincent, L. Otvos, . Jr et al., A Conformation- and Phosphorylation-Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease, Journal of Neurochemistry, vol.69, issue.5, pp.2087-95, 1997.
DOI : 10.1046/j.1471-4159.1997.69052087.x