Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work., Brain Research Reviews, vol.33, issue.1, pp.95-130, 2000. ,
DOI : 10.1016/S0165-0173(00)00019-9
Tau as a biomarker of neurodegenerative diseases, Biomarkers in Medicine, vol.2, issue.4, pp.363-384, 2008. ,
DOI : 10.2217/17520363.2.4.363
URL : https://hal.archives-ouvertes.fr/inserm-00375314
Extracellular tau is toxic to neuronal cells, FEBS Letters, vol.84, issue.20, pp.4842-50, 2006. ,
DOI : 10.1016/j.febslet.2006.07.078
Propagation of Tau Misfolding from the Outside to the Inside of a Cell, Journal of Biological Chemistry, vol.284, issue.19, pp.12845-52, 2009. ,
DOI : 10.1074/jbc.M808759200
Transmission and spreading of tauopathy in transgenic mouse brain, Nature Cell Biology, vol.8, issue.7, pp.909-922, 2009. ,
DOI : 10.1038/ncb1901
Immunization with amyloid-beta attenuates Alzheimerdisease-like pathology in the PDAPP mouse, Nature, vol.400, issue.6740, pp.173-180, 1999. ,
DOI : 10.1038/22124
Active and Passive Immunotherapy for Neurodegenerative Disorders, Annual Review of Neuroscience, vol.31, issue.1 ,
DOI : 10.1146/annurev.neuro.31.060407.125529
Vaccination as a Therapeutic Approach to Alzheimer's Disease, Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, vol.169, issue.1, pp.17-31, 2010. ,
DOI : 10.1002/msj.20156
Active versus passive immunization against hepatitis A in the Israel defence forces: a cost???benefit analysis, Vaccine, vol.18, issue.26, pp.3005-3015, 2000. ,
DOI : 10.1016/S0264-410X(00)00091-8
Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements, Journal of Neuroscience, vol.27, issue.34, pp.9115-9144, 2007. ,
DOI : 10.1523/JNEUROSCI.2361-07.2007
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice, Experimental Neurology, vol.224, issue.2, pp.472-85, 2010. ,
DOI : 10.1016/j.expneurol.2010.05.010
Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model, Journal of Neuroscience, vol.30, issue.49, pp.16559-66, 2010. ,
DOI : 10.1523/JNEUROSCI.4363-10.2010
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain, Journal of Neurochemistry, vol.18, issue.4, pp.658-67, 2011. ,
DOI : 10.1111/j.1471-4159.2011.07337.x
Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein, Archives of Neurology, vol.63, issue.10, pp.1459-67, 2006. ,
DOI : 10.1001/archneur.63.10.1459
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein, FEBS Letters, vol.87, issue.1, pp.25-30, 1996. ,
DOI : 10.1016/0014-5793(96)00271-2
Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration, Acta Neuropathologica, vol.97, issue.3, pp.221-251, 1999. ,
DOI : 10.1007/s004010050978
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease, Acta Neuropathologica, vol.103, issue.1, pp.26-35, 2002. ,
DOI : 10.1007/s004010100423
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility, Journal of Neurochemistry, vol.150, issue.6, pp.1498-508, 2002. ,
DOI : 10.1046/j.1471-4159.2002.01241.x
Abundant Tau filaments and nonapoptotic neurodegeneration in transgenic mide expressing human P301S Tau protein, J Neurosci, vol.22, pp.9340-51, 2002. ,
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits, The American Journal of Pathology, vol.169, issue.2, pp.599-616, 2006. ,
DOI : 10.2353/ajpath.2006.060002
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology, Neurobiology of Disease, vol.43, issue.2, 2011. ,
DOI : 10.1016/j.nbd.2011.04.022
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission, Neurobiology of Learning and Memory, vol.95, issue.3, pp.296-304, 2011. ,
DOI : 10.1016/j.nlm.2010.12.005
Glucocorticoids Increase Amyloid-beta and Tau Pathology in a Mouse Model of Alzheimer's Disease, Journal of Neuroscience, vol.26, issue.35, pp.9047-9056, 2006. ,
DOI : 10.1523/JNEUROSCI.2797-06.2006
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells, FEBS Letters, vol.79, issue.1-3, pp.151-154, 2002. ,
DOI : 10.1016/S0014-5793(02)02460-2
Induction of a specific tau Alzheimer epitope in SY-5Y neuroblastoma cells, NeuroReport, vol.8, issue.1, pp.307-317, 1996. ,
DOI : 10.1097/00001756-199612200-00061
Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease, FEBS Letters, vol.777, issue.3, pp.329-362, 1999. ,
DOI : 10.1016/S0014-5793(99)01480-5
Divergent phosphorylation pattern of tau in P301L tau transgenic mice, European Journal of Neuroscience, vol.18, issue.1, pp.137-184, 2008. ,
DOI : 10.1111/j.1460-9568.2008.06318.x
Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy, Journal of Alzheimer's Disease, vol.5, issue.6, pp.445-54, 2003. ,
DOI : 10.3233/JAD-2003-5604
Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies, Acta Neuropathologica, vol.106, issue.5, pp.419-454, 2003. ,
DOI : 10.1007/s00401-003-0756-4
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Abeta 42 Fibrils, Science, vol.293, issue.5534, pp.1491-1496, 2001. ,
DOI : 10.1126/science.1062097
??-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin, Journal of Neuroscience, vol.29, issue.28, pp.9078-89, 2009. ,
DOI : 10.1523/JNEUROSCI.1071-09.2009
Phosphorylation of Tau at S422 is enhanced by A?? in TauPS2APP triple transgenic mice, Neurobiology of Disease, vol.37, issue.2, pp.294-306, 2010. ,
DOI : 10.1016/j.nbd.2009.09.004
Intra-peritoneal Injection of Polyclonal Anti-Interferon Alpha Antibodies Cross the Blood Brain Barrier and Neutralize Interferon Alpha, Neurochemical Research, vol.6, issue.11, pp.2281-2288, 2008. ,
DOI : 10.1007/s11064-008-9715-8
Getting into the Brain, CNS Drugs, vol.45, issue.1, pp.35-58, 2009. ,
DOI : 10.2165/0023210-200923010-00003
Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies, Journal of Alzheimer's Disease, vol.15, issue.2, pp.157-68, 2008. ,
DOI : 10.3233/JAD-2008-15202
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo, Journal of Neurochemistry, vol.69, issue.4, pp.1005-1019, 2006. ,
DOI : 10.1073/pnas.96.4.1391
C-terminal truncation modulates both nucleation and extension phases of ?? fibrillization, FEBS Letters, vol.336, issue.1, pp.211-216, 2006. ,
DOI : 10.1016/j.febslet.2005.11.077
Early Axonopathy Preceding Neurofibrillary Tangles in Mutant Tau Transgenic Mice, The American Journal of Pathology, vol.171, issue.3, pp.976-92, 2007. ,
DOI : 10.2353/ajpath.2007.070345
Mechanisms of A?? Plaque Clearance following Passive A?? Immunization, Neurodegenerative Diseases, vol.2, issue.5, pp.261-267, 2005. ,
DOI : 10.1159/000090366
Murine models of Alzheimer's disease and their use in developing immunotherapies, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1802, issue.10, pp.847-59, 2010. ,
DOI : 10.1016/j.bbadis.2010.05.004
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L), Journal of Neuroscience, vol.25, issue.46, pp.10637-10684, 2005. ,
DOI : 10.1523/JNEUROSCI.3279-05.2005
Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms, Journal of Neuroscience, vol.25, issue.22, pp.5446-54, 2005. ,
DOI : 10.1523/JNEUROSCI.4637-04.2005
Age-dependent impairment of cognitive and synaptic function in transgenic mouse model of tau pathology (htau mouse), Alzheimer's & Dementia, vol.5, issue.4, pp.10741-10750, 2009. ,
DOI : 10.1016/j.jalz.2009.05.531
Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models: REDUCTION OF TAU PATHOLOGY AND DELAY OF DISEASE PROGRESSION, Journal of Biological Chemistry, vol.286, issue.39, pp.34457-67, 2011. ,
DOI : 10.1074/jbc.M111.229633
Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies, Current Alzheimer Research, vol.8, issue.6, pp.659-65, 2011. ,
DOI : 10.2174/156720511796717177
Tau as a Therapeutic Target for Alzheimers Disease, Current Alzheimer Research, vol.8, issue.6, pp.666-77, 2011. ,
DOI : 10.2174/156720511796717195
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau, Neuron, vol.13, issue.4, pp.989-1002, 1994. ,
DOI : 10.1016/0896-6273(94)90264-X
A Conformation- and Phosphorylation-Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease, Journal of Neurochemistry, vol.69, issue.5, pp.2087-95, 1997. ,
DOI : 10.1046/j.1471-4159.1997.69052087.x