. Botturi, Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4, Respiratory Research, vol.64, issue.1, p.25, 2011.
DOI : 10.1111/j.1398-9995.2009.02056.x

URL : https://hal.archives-ouvertes.fr/inserm-00663859

C. Janson, J. Anto, P. Burney, S. Chinn, R. De-marco et al., The European Community Respiratory Health Survey: what are the main results so far?, European Respiratory Journal, vol.18, issue.3, pp.598-611, 2001.
DOI : 10.1183/09031936.01.00205801

S. Huang, H. Xiao, J. Kleine-tebbe, G. Paciotti, D. Marsh et al., IL-13 expression at the sites of allergen challenge in patients with asthma, J Immunol, vol.155, pp.2688-2694, 1995.

M. Humbert, S. Durham, P. Kimmitt, N. Powell, B. Assoufi et al., Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma, Journal of Allergy and Clinical Immunology, vol.99, issue.5, pp.657-665, 1997.
DOI : 10.1016/S0091-6749(97)70028-9

M. Jutel, M. Akdis, F. Budak, C. Aebischer-casaulta, M. Wrzyszcz et al., IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

P. Stock, R. Dekruyff, and D. Umetsu, Inhibition of the allergic response by regulatory T cells, Current Opinion in Allergy and Clinical Immunology, vol.6, issue.1, pp.12-16, 2006.
DOI : 10.1097/01.all.0000200502.69672.44

L. Van-overtvelt, E. Wambre, B. Maillere, E. Von-hofe, L. A. Balazuc et al., Assessment of Bet v 1-Specific CD4+ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers, The Journal of Immunology, vol.180, issue.7, pp.4514-4522, 2008.
DOI : 10.4049/jimmunol.180.7.4514

E. Ling, T. Smith, X. Nguyen, C. Pridgeon, M. Dallman et al., Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease, The Lancet, vol.363, issue.9409, pp.608-615, 2004.
DOI : 10.1016/S0140-6736(04)15592-X

M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis et al., Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells, The Journal of Experimental Medicine, vol.13, issue.11, pp.1567-1575, 2004.
DOI : 10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9

E. Mamessier, A. Nieves, A. Lorec, P. Dupuy, D. Pinot et al., T-cell activation during exacerbations: a longitudinal study in refractory asthma, Allergy, vol.8595, issue.9, pp.1202-1210, 2008.
DOI : 10.1111/j.1398-9995.2008.01687.x

A. Magnan, L. Mely, C. Camilla, M. Badier, F. Montero-julian et al., Assessment of the Th1/Th2 Paradigm in Whole Blood in Atopy and Asthma, American Journal of Respiratory and Critical Care Medicine, vol.161, issue.6, pp.1790-1796, 2000.
DOI : 10.1164/ajrccm.161.6.9906130

N. Krug, J. Madden, A. Redington, P. Lackie, R. Djukanovic et al., T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma., American Journal of Respiratory Cell and Molecular Biology, vol.14, issue.4, pp.319-326, 1996.
DOI : 10.1165/ajrcmb.14.4.8600935

S. Cho, L. Stanciu, S. Holgate, and S. Johnston, T Cells in Atopic Asthma, American Journal of Respiratory and Critical Care Medicine, vol.171, issue.3, pp.224-230, 2005.
DOI : 10.1164/rccm.200310-1416OC

K. Beier, T. Kallinich, and E. Hamelmann, Master switches of T-cell activation and differentiation, European Respiratory Journal, vol.29, issue.4, pp.804-812, 2007.
DOI : 10.1183/09031936.00094506

M. Kopf, A. Coyle, N. Schmitz, M. Barner, A. Oxenius et al., Inducible Costimulator Protein (Icos) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection, The Journal of Experimental Medicine, vol.254, issue.1, pp.53-61, 2000.
DOI : 10.1084/jem.186.12.2075

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887704

R. Greenwald, G. Freeman, and A. Sharpe, THE B7 FAMILY REVISITED, Annual Review of Immunology, vol.23, issue.1, pp.515-548, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115611

P. Kolar, K. Knieke, J. Hegel, D. Quandt, G. Burmester et al., CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice, Arthritis & Rheumatism, vol.4, issue.1, pp.123-132, 2009.
DOI : 10.1002/art.24181

V. Schmitz, U. Neumann, U. Fischer, J. Langrehr, and P. Neuhaus, Induction of long-term graft acceptance by a combination treatment of donor splenocytes and CTLA4Ig in a high responder rat liver transplantation model, Transplant International, vol.160, issue.10, pp.1187-1196, 2005.
DOI : 10.1038/15260

R. Wiley, S. Goncharova, T. Shea, J. Johnson, A. Coyle et al., Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation, American Journal of Respiratory Cell and Molecular Biology, vol.28, issue.6
DOI : 10.1165/rcmb.2002-0220OC

A. Richter, M. Lohning, and A. Radbruch, Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression, Journal of Experimental Medicine, vol.190, issue.10, pp.1439-1450, 1999.
DOI : 10.1084/jem.190.10.1439

S. Boniface, V. Koscher, E. Mamessier, E. Biaze, M. Dupuy et al., Assessment of T lymphocyte cytokine production in induced sputum from asthmatics: a flow cytometry study, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.164, issue.9, pp.1238-1243, 2003.
DOI : 10.1016/S0140-6736(00)03497-8

K. Botturi, Y. Lacoeuille, P. Thomas, S. Boniface, M. Reynaud-gaubert et al., CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients, European Respiratory Journal, vol.31, issue.6, pp.1167-1176, 2008.
DOI : 10.1183/09031936.00093207

A. Magnan and M. Humbert, Is deficient tolerance the true paradigm for atopic diseases? Clin Exp Allergy, pp.1507-1510, 2005.

J. Lordan, D. Davies, S. Wilson, G. Dent, A. Corkhill et al., The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma, Journal of Allergy and Clinical Immunology, vol.108, issue.6, pp.976-981, 2001.
DOI : 10.1067/mai.2001.119740

F. Tsushima, S. Yao, T. Shin, A. Flies, S. Flies et al., Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy, Blood, vol.110, issue.1, pp.180-185, 2007.
DOI : 10.1182/blood-2006-11-060087

F. Meiler, J. Zumkehr, S. Klunker, B. Ruckert, and C. Akdis, Akdis M: In vivo switch to IL-10-secreting T regulatory cells

A. Coyle, S. Lehar, C. Lloyd, J. Tian, T. Delaney et al., The CD28-Related Molecule ICOS Is Required for Effective T Cell???Dependent Immune Responses, Immunity, vol.13, issue.1, pp.95-105, 2000.
DOI : 10.1016/S1074-7613(00)00011-X

J. Gonzalo, J. Tian, T. Delaney, J. Corcoran, J. Rottman et al., ICOS is critical for T helper cellmediated lung mucosal inflammatory responses, Nature Immunology, vol.2, issue.7, pp.597-604, 2001.
DOI : 10.1038/89739

. Botturi, http://respiratory-research.com/content, Respiratory Research, vol.12121, p.2525, 2011.

A. Coyle and J. Gutierrez-ramos, The role of ICOS and other costimulatory molecules in allergy and asthma, Springer Seminars in Immunopathology, vol.25, issue.3-4, pp.349-359, 2004.
DOI : 10.1007/s00281-003-0154-y

M. Lohning, A. Hutloff, T. Kallinich, H. Mages, K. Bonhagen et al., Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10, The Journal of Experimental Medicine, vol.154, issue.2, pp.181-193, 2003.
DOI : 10.1016/1043-4666(92)90032-M

Y. Chen and H. Shi, CD28/CTLA-4???CD80/CD86 and ICOS???B7RP-1 costimulatory pathway in bronchial asthma, Allergy, vol.24, issue.1, pp.15-26, 2006.
DOI : 10.1002/1521-4141(200202)32:2<585::AID-IMMU585>3.0.CO;2-U

G. Suntharalingam, M. Perry, S. Ward, S. Brett, A. Castello-cortes et al., Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412, New England Journal of Medicine, vol.355, issue.10, pp.1018-1028, 2006.
DOI : 10.1056/NEJMoa063842

S. Provoost, T. Maes, Y. Van-durme, P. Gevaert, C. Bachert et al., Decreased FOXP3 protein expression in patients with asthma, Allergy, vol.132, issue.10, pp.1539-1546, 2009.
DOI : 10.1111/j.1398-9995.2009.02056.x

. Botturi, Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4, Respiratory Research, vol.64, issue.1, p.25, 2011.
DOI : 10.1111/j.1398-9995.2009.02056.x

URL : https://hal.archives-ouvertes.fr/inserm-00663859