The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it, Developmental Dynamics, vol.82, issue.3, pp.706-720, 2005. ,
DOI : 10.1002/dvdy.20345
The basics of epithelial-mesenchymal transition, Journal of Clinical Investigation, vol.119, issue.6, pp.1420-1428, 2009. ,
DOI : 10.1172/JCI39104
Epithelial-Mesenchymal Transitions in Development and Disease, Cell, vol.139, issue.5, pp.871-890, 2009. ,
DOI : 10.1016/j.cell.2009.11.007
Identification and characterization of a fibroblast marker: FSP1, The Journal of Cell Biology, vol.130, issue.2, pp.393-405, 1995. ,
DOI : 10.1083/jcb.130.2.393
Evidence that fibroblasts derive from epithelium during tissue fibrosis, Journal of Clinical Investigation, vol.110, issue.3, pp.341-350, 2002. ,
DOI : 10.1172/JCI0215518
BMP-7 counteracts TGF-??1???induced epithelial-to-mesenchymal transition and reverses chronic renal injury, Nature Medicine, vol.9, issue.7, pp.964-968, 2003. ,
DOI : 10.1038/nm888
Origin of Interstitial Fibroblasts in an Accelerated Model of Angiotensin II-Induced Renal Fibrosis, The American Journal of Pathology, vol.167, issue.5, pp.1193-1205, 2005. ,
DOI : 10.1016/S0002-9440(10)61208-4
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis, The American Journal of Pathology, vol.176, issue.1, pp.85-97, 2010. ,
DOI : 10.2353/ajpath.2010.090517
Resolved: EMT Produces Fibroblasts in the Kidney, Journal of the American Society of Nephrology, vol.21, issue.8, pp.1247-1253, 2010. ,
DOI : 10.1681/ASN.2010060616
Contribution of Epithelial Plasticity to Renal Transplantation???Associated Fibrosis, Transplantation Proceedings, vol.42, issue.9, pp.7-12, 2010. ,
DOI : 10.1016/j.transproceed.2010.07.040
Myofibroblasts and the progression of diabetic nephropathy, Nephrology Dialysis Transplantation, vol.12, issue.1, pp.43-50, 1997. ,
DOI : 10.1093/ndt/12.1.43
Dystroglycan in the Diagnosis of FSGS, Clinical Journal of the American Society of Nephrology, vol.4, issue.11, pp.1747-1753, 2009. ,
DOI : 10.2215/CJN.01510209
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN11See Editorial by Bruneval, p. 1366., Kidney International, vol.68, issue.3, pp.1078-1085, 2005. ,
DOI : 10.1111/j.1523-1755.2005.00500.x
Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months, Nephrology Dialysis Transplantation, vol.24, issue.8, pp.2567-2575, 2009. ,
DOI : 10.1093/ndt/gfp183
Renal Allografts with IF/TA Display Distinct Expression Profiles of Metzincins and Related Genes, American Journal of Transplantation, vol.23, issue.3, pp.517-526, 2009. ,
DOI : 10.1111/j.1600-6143.2008.02512.x
A molecular classifier for predicting future graft loss in late kidney transplant biopsies, Journal of Clinical Investigation, vol.120, issue.6, pp.1862-1872, 2010. ,
DOI : 10.1172/JCI41789DS1
Noninvasive diagnosis of renal interstitial fibrosis and tubular atrophy (IF/TA) by measurement of epithelial to mesenchymal transition (EMT) genes in urine, American Journal of Transplantation, vol.9, pp.226-227, 2009. ,
Characterization of renal interstitial fibroblast-specific protein??1/S100A4-positive cells in healthy and inflamed rodent kidneys, Histochemistry and Cell Biology, vol.4, issue.4-5, pp.335-346, 2005. ,
DOI : 10.1007/s00418-005-0788-z
Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation, Kidney International, vol.58, issue.2, pp.587-597, 2000. ,
DOI : 10.1046/j.1523-1755.2000.00205.x
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver, Proceedings of the National Academy of Sciences, vol.108, issue.1, pp.308-313, 2011. ,
DOI : 10.1073/pnas.1017547108
Immunocytochemical distribution of the calcium-binding protein p9Ka in normal rat tissues: variation in the cellular location in different tissues., Journal of Histochemistry & Cytochemistry, vol.43, issue.2, pp.169-180, 1995. ,
DOI : 10.1177/43.2.7822773
Antibodies against macrophages that overlap in specificity with fibroblasts, Kidney International, vol.67, issue.6, pp.2488-2493, 2005. ,
DOI : 10.1111/j.1523-1755.2005.00358.x
Immunofluorometric Assay for the Metastasis-Related Protein S100A4: Release of S100A4 from Normal Blood Cells Prohibits the Use of S100A4 as a Tumor Marker in Plasma and Serum, Tumor Biology, vol.25, issue.1-2, pp.31-40, 2004. ,
DOI : 10.1159/000077721
Modulation of mts1 expression in mouse and human normal and tumor cells, Electrophoresis, vol.19, issue.1, pp.463-468, 1994. ,
DOI : 10.1002/elps.1150150163
Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer, International Journal of Cancer, vol.123, issue.7, pp.1433-1444, 2007. ,
DOI : 10.1002/ijc.22850
Early role of Fsp1 in epithelialmesenchymal transformation, Am J Physiol, vol.273, pp.563-574, 1997. ,
S100A4: a common mediator of epithelial???mesenchymal transition, fibrosis and regeneration in diseases?, Journal of Molecular Medicine, vol.17, issue.Pt 14, pp.507-522, 2008. ,
DOI : 10.1007/s00109-007-0301-3
S100A4 and Metastasis, The American Journal of Pathology, vol.176, issue.2, pp.528-535, 2010. ,
DOI : 10.2353/ajpath.2010.090526
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808059
Risk Factors for Early Epithelial to Mesenchymal Transition in Renal Grafts, American Journal of Transplantation, vol.13, issue.12, pp.2937-2946, 2006. ,
DOI : 10.1111/j.1600-6143.2005.01042.x
Biomarkers for epithelial-mesenchymal transitions, Journal of Clinical Investigation, vol.119, issue.6, pp.1429-1437, 2009. ,
DOI : 10.1172/JCI36183
Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron, BMC Physiology, vol.4, issue.1, p.10, 2004. ,
DOI : 10.1186/1472-6793-4-10
Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue, BMC Cell Biology, vol.9, issue.1, p.13, 2008. ,
DOI : 10.1186/1471-2121-9-13
Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition, The FASEB Journal, vol.24, issue.6, pp.1838-1851, 2010. ,
DOI : 10.1096/fj.09-151639
Vimentin is a novel AKT1 target mediating motility and invasion, Oncogene, vol.68, issue.4, pp.457-470, 2011. ,
DOI : 10.1038/onc.2010.421
Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies, PLoS ONE, vol.5, issue.4, p.10105, 2010. ,
DOI : 10.1371/journal.pone.0010105.s005
Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation, Anticancer Res, vol.28, pp.327-334, 2008. ,
Impaired wound healing in embryonic and adult mice lacking vimentin, J Cell Sci, vol.113, pp.2455-2462, 2000. ,
Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance., Journal of Clinical Investigation, vol.100, issue.6, pp.1520-1528, 1997. ,
DOI : 10.1172/JCI119675
Normal tubular regeneration and differentiation of the post-ischemic kidney in mice lacking vimentin, Am J Pathol, vol.150, pp.1361-1371, 1997. ,
Immunohistochemical demonstration of vimentin and S-100 protein in the kidneys, Gen Physiol Biophys, vol.18, pp.100-102, 1999. ,
Virtanen I: Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys, Lab Invest, vol.50, pp.552-559, 1984. ,
Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney, Am J Pathol, vol.129, pp.1-8, 1987. ,
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells., Journal of Clinical Investigation, vol.93, issue.5, pp.2175-2188, 1994. ,
DOI : 10.1172/JCI117214
Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis, American Journal of Kidney Diseases, vol.38, issue.4, pp.761-769, 2001. ,
DOI : 10.1053/ajkd.2001.27693
Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies, Kidney International, vol.62, issue.1, pp.137-146, 2002. ,
DOI : 10.1046/j.1523-1755.2002.00430.x
Epithelial to Mesenchymal Transition During Late Deterioration of Human Kidney Transplants: The Role of Tubular Cells in Fibrogenesis, American Journal of Transplantation, vol.13, issue.2, pp.1367-1374, 2005. ,
DOI : 10.1097/00041552-200301000-00005
Wnt/??-Catenin Signaling Promotes Renal Interstitial Fibrosis, Journal of the American Society of Nephrology, vol.20, issue.4, pp.765-776, 2009. ,
DOI : 10.1681/ASN.2008060566
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663839
Blockade of Wnt/??-Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury, Journal of the American Society of Nephrology, vol.22, issue.1, pp.90-103, 2011. ,
DOI : 10.1681/ASN.2009121236
Wnt-Dependent ??-Catenin Signaling Is Activated after Unilateral Ureteral Obstruction, and Recombinant Secreted Frizzled-Related Protein 4 Alters the Progression of Renal Fibrosis, Journal of the American Society of Nephrology, vol.16, issue.8, pp.2373-2384, 2005. ,
DOI : 10.1681/ASN.2004110949
Wnt Pathway Regulation in Chronic Renal Allograft Damage, American Journal of Transplantation, vol.162, issue.Pt 9, pp.2223-2239, 2009. ,
DOI : 10.1111/j.1600-6143.2009.02762.x
Tubular nuclear accumulation of Snail and epithelial phenotypic changes in human myeloma cast nephropathy, Human Pathology, vol.42, issue.8, 2011. ,
DOI : 10.1016/j.humpath.2010.11.006
The Kidney, pp.995-996, 2008. ,
Epithelial-Mesenchymal Transition as a Potential Explanation for Podocyte Depletion in Diabetic Nephropathy, American Journal of Kidney Diseases, vol.54, issue.4 ,
DOI : 10.1053/j.ajkd.2009.05.009
Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions, American Journal of Transplantation, vol.23, issue.4, pp.753-760, 2008. ,
DOI : 10.1046/j.1523-1755.1999.00299.x
Epithelial-to-Mesenchymal Transition in Early Transplant Tubulointerstitial Damage, Journal of the American Society of Nephrology, vol.19, issue.8, pp.1571-1583, 2008. ,
DOI : 10.1681/ASN.2007050580
Early Epithelial Phenotypic Changes Predict Graft Fibrosis, Journal of the American Society of Nephrology, vol.19, issue.8, pp.3482-3488, 2008. ,
DOI : 10.1681/ASN.2007101160
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488257
Epithelial-mesenchymal transition and its implications for fibrosis, Journal of Clinical Investigation, vol.112, issue.12, pp.1776-1784, 2003. ,
DOI : 10.1172/JCI200320530
New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis, Journal of the American Society of Nephrology, vol.21, issue.2, pp.212-222, 2010. ,
DOI : 10.1681/ASN.2008121226
Complex networks orchestrate epithelial???mesenchymal transitions, Nature Reviews Molecular Cell Biology, vol.117, issue.2, pp.131-142, 2006. ,
DOI : 10.1038/nrm1835
A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression, The EMBO Journal, vol.6, issue.19, pp.3446-3458, 2005. ,
DOI : 10.1038/sj.emboj.7600781
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition, Journal of Clinical Investigation, vol.117, pp.3810-3820, 2007. ,
DOI : 10.1172/JCI30487DS1
Hypoxia-inducible factor-1?? induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition, Kidney International, vol.75, issue.12, pp.1278-1287, 2009. ,
DOI : 10.1038/ki.2009.62
Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis, J Am Soc Nephrol, vol.13, pp.96-107, 2002. ,
The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model, Fibrogenesis & Tissue Repair, vol.3, issue.1, p.1, 2010. ,
DOI : 10.1186/1755-1536-3-1
TGF-??1-Induced Epithelial-to-Mesenchymal Transition and Therapeutic Intervention in Diabetic Nephropathy, American Journal of Nephrology, vol.31, issue.1, pp.68-74, 2009. ,
DOI : 10.1159/000256659
Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis, Transplantation Reviews, vol.22, issue.1, pp.1-5, 2008. ,
DOI : 10.1016/j.trre.2007.09.004