Quality of life in patients aged 80 or over after ICU discharge

cc8231 CCJ Research Quality of life in patients aged 80 or over after ICU discharge Tabah Alexis atabah@chu-grenoble.fr Philippart Francois fphilippart@gmail.com Timsit Francois Jean jftimsit@chu-grenoble.fr Willems Vincent vwillems@gmail.com Français Adrien adrien.francais@gmail.com Leplège Alain alain.leplege@wanadoo.fr Carlet Jean jeancarlet@gmail.com Bruel Cédric ced.bruel@laposte.net Misset Benoit bmisset@hpsj.fr Garrouste-Orgeas Maité mgarrouste@hpsj.fr

Medical-Surgical ICU, Saint Joseph Hospital Network, 185 rue Raymond Losserand, 75014 Paris, France

Cytokines and inflammation unit, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France

INSERM U823 "Epidemiology of cancers and severe diseases", Albert Bonniot Institute, Rond-point de la Chantourne, 38706 La Tronche Cedex

Medical Intensive Care Unit, Albert Michallon Teaching Hospital, Joseph Fournier University, BP 217, 38043 Grenoble cedex 09, France

Recherche épistémologiques et historiques sur les sciences exactes et les institutions scientifiques (REHSEIS), UMR 7596, Université Paris Diderot, Paris VII, 5 rue Thomas Mann, 75205 Paris Cedex 13, France

University Paris Descartes, 12 rue de l'école de médecine, 75005 Paris, France

Critical Care 1364-8535 2010 14 1 R2 http://ccforum.com/content/14/1/R2 See related letter by Koeze and Zijlstra, http://ccforum.com/content/14/4/434 20064197 10.1186/cc8231 29 6 2009 10 9 2009 30 11 2009 8 1 2010 8 1 2010 2010 Tabah et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction

Our objective was to describe self-sufficiency and quality of life one year after intensive care unit (ICU) discharge of patients aged 80 years or over.

Methods

We performed a prospective observational study in a medical-surgical ICU in a tertiary non-university hospital. We included patients aged 80 or over at ICU admission in 2005 or 2006 and we recorded age, admission diagnosis, intensity of care, and severity of acute and chronic illnesses, as well as ICU, hospital, and one-year mortality rates. Self-sufficiency (Katz Index of Activities of Daily Living) was assessed at ICU admission and one year after ICU discharge. Quality of life (WHO-QOL OLD and WHO-QOL BREF) was assessed one year after ICU discharge.

Results

Of the 115 consecutive patients aged 80 or over (18.2% of admitted patients), 106 were included. Mean age was 84 ± 3 years (range, 80 to 92). Mortality was 40/106 (37%) at ICU discharge, 48/106 (45.2%) at hospital discharge, and 73/106 (68.9%) one year after ICU discharge. In the 23 patients evaluated after one year, self-sufficiency was unchanged compared to the pre-admission status. Quality of life evaluations after one year showed that physical health, sensory abilities, self-sufficiency, and social participation had slightly worse ratings than the other domains, whereas social relationships, environment, and fear of death and dying had the best ratings. Compared to an age- and sex-matched sample of the general population, our cohort had better ratings for psychological health, social relationships, and environment, less fear of death and dying, better expectations about past, present, and future activities and better intimacy (friendship and love).

Conclusions

Among patients aged 80 or over who were selected at ICU admission, 80% were self-sufficient for activities of daily living one year after ICU discharge, 31% were alive, with no change in self-sufficiency and with similar quality of life to that of the general population matched on age and sex. However, these results must be interpreted cautiously due to the small sample of survivors.

Introduction

The human lifespan is increasing across the world as a result of economic progress, technological advances, and improved healthcare. In 2007, it was estimated that 98 million people, or 1.5% of the world population, were older than 80 years 1. French census data show a steady increase in the proportion of elderly individuals and, in 2008, 3.9 million individuals were aged 75 to 84 years and 1.4 million were older than 85 years 2.

One consequence of this increasing lifespan is that a growing number of very elderly patients are being admitted to the intensive care unit (ICU). Critical care seeks not only to ensure survival, but also to restore the pre-admission level of function and to return the patient to his or her pre-admission living arrangements. Elderly patients who survive a critical illness at the cost of further functional impairments may require nursing-home admission, an outcome most of them deem undesirable 3. Whereas self-sufficiency is an objective outcome, quality-of-life assessments provide information on outcomes perceived by ICU survivors 4. The World Health Organization (WHO) defines quality of life as 'an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns' 5.

Few data are available on quality of life in very elderly ICU survivors compared to the general population 678. One study detected no difference 8, another found decreases in specific domains with similar overall quality of life 6, and two studies found worse quality of life 79. These discrepancies may be ascribable to differences in the tools used to assess quality of life and to the use of tools designed for the general population that may be inappropriate in the very old 10.

The aim of this study was to evaluate self-sufficiency and quality of life one year after ICU discharge in patients aged 80 years or over. Quality of life was assessed using a validated tool developed for the elderly by the World Health Organization.

Materials and methods

Setting

The study was performed at the Saint Joseph Hospital, a 460-bed tertiary-care non-university hospital for adults, located in Paris, France. The hospital provides services in all the medical specialties and in all fields of surgery except neurosurgery. The ICU is a 10-bed medical unit that admits about 400 patients per year (mean age, 62 years), of whom 70% have medical conditions. In our ICU, we have no predefined admission criteria. Our triage process has been described elsewhere 9.

Patients

From January 1, 2005, to December 31, 2006, we included all patients aged 80 years or over at ICU admission. Patients who were admitted several times during the study period had only their first stay included in the study. For each patient, the attending intensivist completed a case-report form in a database using data-capture software (RHEA, Outcomerea, Rosny Sous Bois, France). The following information was recorded prospectively: age and sex; admission category (medical, scheduled surgery, or unscheduled surgery); invasive procedures (number of arterial and/or venous central lines, endotracheal and noninvasive ventilation, dialysis, and tracheotomy); use of vasoactive agents and inotropic support; and patient location prior to ICU admission (with transfer from wards defined as being in the same hospital or another hospital before ICU admission). Nine reasons for ICU admission were defined prospectively before the study (respiratory failure, heart failure, renal failure, coma, multiple organ failure, chronic obstructive pulmonary disease, monitoring, trauma, and scheduled surgery). Co-morbidities were assessed using the McCabe score 11 and the Knaus classification system 12. The McCabe score distinguishes two categories of underlying diseases based on whether death is likely to occur within five years or within one year 11. Severity of the acute illness and organ dysfunction were measured at ICU admission using the Simplified Acute Physiology Score (SAPS II) 13, the Logistic Organ Dysfunction (LOD) score 14, and the Sepsis-Related Organ Assessment (SOFA) 15. Withholding and withdrawal decisions, which were made according to the recommendations of the Francophone Society for Critical Care (SRLF) 16, were recorded; as well as lengths of the stays in the ICU and acute-care hospital and vital status at ICU and hospital discharge.

Quality of life

Information on prior self-sufficiency was obtained from the patient or family members, either at admission or within the first few days after admission, according to standard practice in our unit. Self-sufficiency was evaluated using the modified Katz Index of Activities of Daily Living (ADL), which assesses the ability to perform six basic daily activities (bathing, dressing, toileting, transferring, continence, and feeding) on a seven-point scale where zero indicates complete dependence and six complete independence 17.

Long-term quality of life was assessed using the WHOQOL-BREF and WHOQOL-OLD questionnaires developed by the World Health Organization (WHO) 1819. The WHOQOL-BREF, which is the abbreviated version of the WHOQOL-100 19, is a cross-culturally developed and validated questionnaire that can be used in specific cultural settings to collect data suitable for subsequent comparison across cultures. It has 26 items that cover four domains: physical health, psychological health, social relationships, and environment. It also measures the individual's perceptions of quality of life and health via two items ('How would you rate your quality of life?' and 'How satisfied are you with your health?'), each rated from 1 (very poor/dissatisfied) to 5 (very good/satisfied). The WHOQOL-OLD was developed as an add-on module that can be used with other WHOQOL instruments to specifically address important facets of quality of life in older adults 18. It has 24 items that cover six facets (sensory abilities; autonomy; past, present, and future activities; social participation; death and dying; and intimacy). The WHOQOL-BREF questionnaire is available on the web 20 and from national WHO field centers. Domain scores are calculated from the items then converted to an overall percentile scale that ranges from very poor (0%) to very good (100%).

Follow-up measures

Outcomes one year after ICU discharge were assessed over the phone. Patients who failed to answer the first call were called again on different days, for a total of four calls. When we were unable to contact the patient by phone, we sought vital status information by calling the primary care physician and by looking for a death certificate at the appropriate registry office (or consulate if the patient was not French). The Katz Index and the WHOQOL-OLD and WHOQOL-BREF questionnaires were completed during a telephone interview conducted by one of us (AT). Because quality of life is a subjective personal concept that cannot be readily evaluated by relatives, only the patients completed the quality-of-life questionnaires. In contrast, relatives were asked for information on self-sufficiency that could not be obtained from the patients. The institutional review board waived requirement for written informed consent at ICU admission. Each patient received information about their inclusion in the study at ICU discharge and at the beginning of the phone call, and then asked to consent to the interview.

Statistical analysis

Quantitative data are reported as mean ± SD if normally distributed and as median (interquartile range (IQR)) otherwise. Qualitative data are reported as n (%). WHOQOL scores were calculated using the files created in SPSS by the WHO. The control group was a random sample of the general population matched on age and sex to our patients and derived from the sample used to validate the French version of the WHOQOL-OLD. Comparisons of self-sufficiency before and after the ICU stay and comparisons of WHOQOL scores after the ICU stay in our patients and in the general population were done using the Wilcoxon test for paired data. Statistical analyses were performed using SAS software (SAS 9.1, SAS Institute, Cary, NC, USA).

Results

Patients

During the two-year study period, among the 630 consecutive admissions to our ICU, 115 (18.2%) were for patients aged 80 years or over (mean age, 84 ± 3 years; range, 80 to 92). There were seven readmissions (one patient readmitted twice and five patients readmitted once each, of whom two were alive after one year and completed our evaluation). We excluded two patients with missing data, which left 106 patients for the study. These patients had a mean age of 84 ± 2 years. Among them, 69 (65.1%) had medical conditions, 21 (19.8%) required unscheduled surgery, and 68 (64%) were transferred from wards. At admission, the mean Simplified Acute Physiology Score was 45 ± 18.3 points and the mean Logistic Organ Dysfunction score was 5.4 ± 3.5 points. During the ICU stay, 63 (59.4%) required ventilatory assistance, 48 (45.3%) epinephrine/norepinephrine, and 20 (18.9%) dialysis. The median ICU stay was six days (IQR, 3 to 11) and the median post-ICU hospital stay was eight days (IQR, 0 to 18.5).

Of the 106 patients, 40 (37.7%) died in the ICU and 39 (36.8%) had treatment-limitation decisions, which consisted in withholding life-support in 22 (20.8%) patients and withdrawing life support in 20 (18.9%) patients, with three patients having both categories of decisions.

Follow-up and quality of life

Of the 66 (62.2%) patients discharged alive from the ICU, eight died before hospital discharge. Hospital mortality was 48/106 (45.2%). In addition, 25 patients died before the one-year evaluation. Thus, one-year mortality was 73/106 (68.9%). Of the 33 survivors at one year, seven refused the evaluation (two were unhappy with our institution, one stated having insufficient time, two had hearing loss, and two lived at home but did not answer our multiple calls). Of the 26 remaining patients, three had dementia that precluded them from completing the evaluation. Self-sufficiency in these three patients was assessed by the relatives; they had ADL scores of 4, 4, and 2, respectively. Quality of life was not assessed in these three patients.

Quality of life was therefore assessed in 23 patients, whose mean age was 84 ± 3 years; there were 17 (73.9%) males (Table 1). Mean time from ICU discharge to evaluation was 471 ± 121 days (25^thto 75^th:375 to 583), due to difficulties experienced in locating some of the patients. Mean phone call duration was 42 ± 14 minutes. As shown in Table 2, self-sufficiency was not modified after the ICU stay compared to the pre-ICU status (median index values, 6 vs. 6, respectively). Table 3 compared quality-of-life data in the 23 patients and in the general population matched on sex and age. The survivors had significantly higher scores for psychological health; social relationships; environment; fear of death and dying; expectations about past, present, and future activities; and intimacy (friendship and love). Of the 23 patients, 18 (78%) said they would agree to another ICU admission should the need occur in the future.

Table 1

Main characteristics of survivors and nonsurvivors

Variables

Non survivors

N = 83

Survivors

N = 23

P value

Age in years, mean ± SD (range)

84 ± 3 (80 to 93)

84 ± 3 (80 to 92)

0.99

Males, n (%)

41 (49.4)

17 (73.9)

0.03

Body mass index, kg/m²

25.6 ± 5

24.1 ± 4

0.19

McCabe classification, n (%)

0.042

Underlying disease: none or nonfatal

32 (38.6)

14 (60.9)

Underlying disease expected to cause death within five years

36 (43.4)

9 (39.1)

Underlying disease expected to cause death within one year

15 (18.1)

Underlying diseases according to Knaus, n (%)

At least one co-morbid condition

38 (45.8)

7 (30.4)

0.18

Hepatic

1 (1.2)

Cardiovascular

27 (32.5)

4 (17.4)

0.15

Pulmonary

19 (22.9)

3 (13)

0.30

Renal

9 (10.8)

1 (4.3)

0.34

Immunosuppression

3 (3.6)

1 (4.3)

0.87

Patient location before ICU admission, n (%)

Transfer from ward

54 (65.1)

14 (60.9)

0.71

Pre-ICU hospital stay,

median (IQR)

2 (0 - 6)

1 (0 - 5)

0.57

Emergency room/home, n (%)

29 (34.9)

9 (39.1)

0.71

Admission category, n (%)

0.27

Medicine

55 (66.3)

14 (60.9)

Unscheduled surgery

14 (16.9)

7 (30.4)

Scheduled surgery

14 (16.9)

2 (8.7)

Main symptom at admission, n (%)

Septic shock and multiple organ failure

16 (19.3)

8 (34.8)

0.11

Other shock

11 (13.3)

3 (13)

0.97

Acute respiratory failure

19 (22.9)

4 (17.4)

0.57

Acute COPD exacerbation

9 (10.8)

1 (4.3)

0.34

Acute renal failure

11 (13.3)

1 (4.3)

0.23

Coma

6 (7.2)

3 (13)

0.37

Monitoring

11 (13.3)

3 (13)

0.97

Severity of illness at admission, Mean ± SD

SAPS II

47 ± 19.2

38.1 ± 12.7

0.047

LOD

5.7 ± 3.7

4.3 ± 2.5

0.10

SOFA

6.6 ± 3

5.7 ± 3

0.11

Intensity of care, n (%)

Endotracheal mechanical ventilation

49 (59)

14 (60.9)

0.87

Epinephrine/Norepinephrine

38 (45.8)

10 (43.5)

0.84

Dobutamine

22 (26.5)

3 (13)

0.17

Dialysis

19 (22.9)

1 (4.3)

0.04

Central venous catheter

54 (65.1)

12 (52.2)

0.25

Arterial catheter

33 (39.8)

8 (34.8)

0.66

Length of ICU stay, days, median (IQR)

6 (3 - 12)

5 (3 - 9)

0.42

Length of post-ICU hospital stay, median (IQR)

1 (0 - 15)

17 (9 - 28)

0.0007

IQR = interquartile range; COPD = chronic obstructive pulmonary disease; SAPS II = Simplified Acute Physiologic Score 13; LOD Logistic Organ Failure 14; SOFA = Sepsis-Related Organ Assessment 15

Table 2

Self-sufficiency before and after the ICU stay shown by percent of patients

Nonsurvivors

N = 83

Patients alive with one-year QOL data

N = 23

Self-sufficiency¹

Before ICU admission

After one year²

ADL = 6

55 (66.3)

19 (82.6)

17 (74)

ADL = 5

4 (4.8)

1 (4.3)

2 (8.7)

ADL = 4

8 (9.6)

3 (13)

2 (8.7)

ADL = 3

1 (1.2)

1 (4.3)

ADL = 2

5 (6)

ADL = 1

2 (2.4)

1 (4.3)

ADL = 0

8 (9.6)

Median ADL Score

(IQR)

6 (4 to 6)

6 (6 to 6)

6 (5 to 6)

¹Self-sufficiency was assessed using the Katz Index of Activities of Daily Living (ADL) 17, with each activity being scored from zero (complete dependence) to six (complete independence).

QOL = quality of life; ICU = intensive care unit

²P = 0.80 for the comparison of self sufficiency one year after ICU discharge and before ICU admission in the 23 alive patients, for the whole activities of daily living

Table 3

Quality of life of the survivors compared to the general population

Study population

N = 23

General population matched on age and gender

P value

QOL-BREF

Overall perception of QOL

73.9 ± 18.5

73 ± 19.6

0.87

Overall perception of health

72.7 ± 18.0

63.5 ± 21.4

0.12

Physical health

62.1 ± 16.6

56.7 ± 18

0.29

Psychological health

69.4 ± 16.3

56.5 ± 18.7

0.02

Social relationships

73.2 ± 16.7

60.2 ± 17.0

0.01

Environment

77.3 ± 12.1

67.5 ± 13.4

0.01

QOL-OLD

Sensory abilities

64.7 ± 30.0

64.4 ± 18.4

0.96

Autonomy

63.6 ± 12.6

54 ± 22.6

0.08

Death and dying

77.9 ± 19.9

62.6 ± 23.1

0.02

Past, present and future activities

69.7 ± 17.7

57.6 ± 15.7

0.02

Social participation

60.5 ± 21.9

54.9 ± 18.1

0.35

Intimacy

68.2 ± 18.2

55.1 ± 20.3

0.03

QOL = quality of life; ICU = intensive care unit

QOL was assessed on a scale from 0 = very poor to 100 = very good

Discussion

We found that patients aged 80 years or over who were selected for ICU admission had no change in self-sufficiency one year after ICU discharge compared to the pre-admission status and had similar quality of life compared to age-and sex-matched individuals from the general population. After one year, 78% of evaluated patients said they would agree to an ICU admission should they experience another critical illness.

During the study period, patients aged 80 years or over accounted for 18.2% of all patients admitted to our ICU. Patients in this age group were often refused ICU admission 9. The 18.2% admission rate was in line with data in the French ICU Outcomerea database 21. Mortality rates were high in our population: 37% at ICU discharge, 45.2% at hospital discharge, and 68.9% one year after ICU discharge. ICU and hospital mortality rates have varied across studies 92223242526, probably because of case-mix differences. In contrast, one-year and two-year mortality rates have usually been within the 60% to 70% range 92223242526, in line with our results. Our relatively high ICU mortality rate was explained by the large proportions of medical patients, patients transferred from other wards, patients with severe illness at admission requiring a high level of care not always provided to the very elderly 27, and treatment limitations during the ICU stay (40% of patients).

Self-sufficiency was not changed one year after ICU admission, in keeping with earlier data 689242528. Furthermore, our patients had an overall good perception of their quality of life, comparable to that of the general population. On both quality-of-life questionnaires, mean scores on all facets were consistently within the 60% to 80% range. Physical health, sensory abilities, self-sufficiency, and social participation had slightly lower ratings than the other domains. Ratings were highest for social relationships, environment, and death and dying. Compared to an age-and sex-matched sample of the general population, our patients had better scores for psychological health; social relationships; environment; fear of death and dying; expectations about past, present, and future activities; and intimacy (friendship and love). One hypothesis is that surviving a life-threatening illness may offer opportunities for building psychological strength and diminishing the fear of death and dying. Moreover, patients probably adjust their expectations when faced with serious illness and disability, which may lead them to assign higher ratings to their quality of life. The results from this study must be interpreted cautiously due to the small sample and are at variance with those of our previous study in a similar population, in which quality of life was significantly poorer one year after ICU admission 9. In this earlier study 9, quality of life was assessed using the modified Perceived Quality of Life scale and Nottingham Health Profile. Neither scale is specifically designed for older individuals. Therefore, the present study may provide a better assessment of quality of life. Both studies assessed self-sufficiency using the Katz Index of ADLs, and neither found any change after the ICU stay.

Most of the survivors said they would consent to ICU admission should they experience another acute life-threatening illness. The preferences of elderly patients regarding ICU admission are largely unknown in France and elsewhere, although surrogate designation is known to be popular in France 29. Absence of a surrogate, or limited ability of the surrogate to predict the patient's wishes, may lead to ICU refusal of elderly patients who, if conscious, would choose ICU admission 30. In our earlier study of patients aged 80 years or over, half the survivors said they would agree to another ICU admission 9, whereas the proportion was 72% in the present study. Differences in preferences of elderly patients may arise because of variations over time 313233, most notably increased vulnerability 34 and family burden 35. Patients who are in stable condition one year after an ICU stay may be more likely to express positive perceptions of their quality of life than patients with unstable disease. Furthermore, having experienced and survived an ICU stay may lead to a more positive opinion about ICU admission, compared to patients with no ICU experience. Patient preferences should be taken into account when deciding whether ICU admission is in order.

This study has several limitations. First, the data were obtained at a single center and may not be applicable to other ICUs. Second, the number of patients evaluated after one year was small. This limitation is ascribable to the usual high mortality rate in patients aged 80 years and over who require ICU admission. However, waiting one year to perform the assessment provides a sound estimate of post-ICU quality of life 4. Third, our patients were selected for ICU admission based largely on self-sufficiency and on the expectation that life-supporting treatment would not prove futile. Our data may not apply to all patients aged 80 years and over who are admitted to the ICU, as admission policies vary widely across countries and within a given country. Furthermore, the patients evaluated in our study were long-term survivors and were willing to take the time to complete our evaluation.

Conclusions

In a highly selected cohort of elderly patients, among whom fewer than one-third were alive one year after ICU discharge, self-sufficiency was unchanged one year after ICU admission and quality of life was comparable to that in the same-age general population. These results invite further investigations of the preferences of elderly patients regarding ICU admission. We are currently planning such a study.

Key messages

• Patients aged 80 years or over who were admitted to the ICU were carefully selected based on self-sufficiency.

• Unlike previous studies, we found that one-year survival after ICU discharge was about 30%.

• In this small sample of survivors, one year after ICU discharge, the patients were satisfied with their level of self-sufficiency and quality of life.

• Quality of life, physical health, sensory abilities, self-sufficiency, and social participation had slightly lower ratings than other domains. Ratings were highest for social relationships, environment, and death and dying.

• Patient preferences should be taken into account when deciding whether ICU admission is in order.

Abbreviations

ADL: activities of daily living; COPD: chronic obstructive pulmonary disease; ICU: Intensive care unit; IQR: interquartile range; LOD: logistic organ failure; SAPS II: Simplified Acute Physiologic Score II; SOFA: Sepsis-Related Organ Assessment; SPSS: Statistical Package for the Social Sciences; SRLF: Societé de Réanimation de Langue Française; WHO: World Health Organization; WHOQOL-100: World Health Organization-Quality of Life 100; WHOQOL-BREF: World Health Organization-Quality of Life BREF; WHOQOL-OLD: World Health Organization-Quality of Life OLD.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

AT collected the data and wrote the manuscript; MGO contributed to the design of the study and wrote the manuscript. JFT contributed to the design of the study, did the statistical analysis with responsibility for integrity of the data and the accuracy of the data analysis, and contributed to the final revision of the manuscript for important intellectual content. AF did the statistical analysis with responsibility for integrity of the data and the accuracy of the data analysis. AL contributed to the design of the study. FP, VW, JC, CB, and BM contributed to the final revision of the manuscript for important intellectual content. All the authors read and approved the final manuscript.

Acknowledgements

We thank A. Wolfe, MD, for helping to prepare this manuscript and E. Ecosse for providing the quality-of-life data for the general population.

International Data Base: World population information http://www.census.gov/ipc/www/idb/worldpopinfo.php Population - Evolution du nombre de personnes âgées http://www.insee.fr/fr/themes/tableau.asp?reg_id=0&ref_id=NATSOS02130 Hospital discharge to care facility: a patient-centered outcome for the evaluation of intensive care for octogenarians Rady MY Johnson DJ Chest 2004 126 1583 1591 10.1378/chest.126.5.1583 15539731 Health-related quality of life: an outcome variable in critical care survivors Azoulay E Kentish-Barnes N Pochard F Chest 2008 133 339 341 10.1378/chest.07-2547 18252911 The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization Soc Sci Med 1995 41 1403 1409 10.1016/0277-9536(95)00112-K 8560308 Outcome, functional autonomy, and quality of life of elderly patients with a long-term intensive care unit stay Montuclard L Garrouste-Orgeas M Timsit JF Misset B De Jonghe B Carlet J Crit Care Med 2000 28 3389 3395 10.1097/00003246-200010000-00002 11057791 Quality of life in the very elderly after cardiac surgery: a comparison of SF-36 between long-term survivors and an age-matched population Sjogren J Thulin LI Gerontology 2004 50 407 410 10.1159/000080179 15477702 Quality of life and functional level in elderly patients surviving surgical intensive care Udekwu P Gurkin B Oller D Lapio L Bourbina J J Am Coll Surg 2001 193 245 249 10.1016/S1072-7515(01)00994-2 11548793 Decision-making process, outcome, and 1-year quality of life of octogenarians referred for intensive care unit admission Garrouste-Orgeas M Timsit JF Montuclard L Colvez A Gattolliat O Philippart F Rigal G Misset B Carlet J Intensive Care Med 2006 32 1045 1051 10.1007/s00134-006-0169-7 16791667 Self-reported health complaints and their prediction of overall and health-related quality of life among elderly people Borglin G Jakobsson U Edberg AK Hallberg IR Int J Nurs Stud 2005 42 147 158 10.1016/j.ijnurstu.2004.06.003 15680613 Gram-negative bacteremia, I: etiology and ecology McCabe W Jackson G Arch Intern Med 1962 847 855 APACHE II: a severity of disease classification system Knaus WA Draper EA Wagner DP Zimmerman JE Crit Care Med 1985 13 818 829 10.1097/00003246-198510000-00009 3928249 A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study Le Gall JR Lemeshow S Saulnier F JAMA 1993 270 2957 2963 10.1001/jama.270.24.2957 8254858 The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group Le Gall JR Klar J Lemeshow S Saulnier F Alberti C Artigas A Teres D JAMA 1996 276 802 810 10.1001/jama.276.10.802 8769590 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Vincent JL Moreno R Takala J Willatts S De Mendonca A Bruining H Reinhart CK Suter PM Thijs LG Intensive Care Med 1996 22 707 710 10.1007/BF01709751 8844239 Limitation and cessation of active treatment in resuscitation for adults. Recommendations of the French Language Resuscitation Society (SRLF) Rev Pneumol Clin 2003 59 227 236 14699302 Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living Katz S J Am Geriatr Soc 1983 31 721 727 6418786 Development of the WHOQOL-old module Power M Quinn K Schmidt S Qual Life Res 2005 14 2197 2214 10.1007/s11136-005-7380-9 16328900 The World Health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group Skevington SM Lotfy M O'Connell KA Qual Life Res 2004 13 299 310 10.1023/B:QURE.0000018486.91360.00 15085902 WHOQOL-BREF http://www.who.int/substance_abuse/research_tools/whoqolbref/en/index.html Outcomerea http://www.outcomerea.org Prognosis of patients aged 80 years and over admitted in medical intensive care unit Boumendil A Maury E Reinhard I Luquel L Offenstadt G Guidet B Intensive Care Med 2004 30 647 654 10.1007/s00134-003-2150-z 14985964 Outcome of intensive care of the "oldest-old" critically ill patients Chelluri L Pinsky MR Grenvik AN Crit Care Med 1992 20 757 761 10.1097/00003246-199206000-00010 1597028 Long-term outcome of critically ill elderly patients requiring intensive care Chelluri L Pinsky MR Donahoe MP Grenvik A JAMA 1993 269 3119 3123 10.1001/jama.269.24.3119 8505814 Intensive care unit outcome in the very elderly Kass JE Castriotta RJ Malakoff F Crit Care Med 1992 20 1666 1671 10.1097/00003246-199212000-00011 1458943 Short-term and long-term mortality in very elderly patients admitted to an intensive care unit De Rooij SE Govers A Korevaar JC Abu-Hanna A Levi M de Jonge E Intensive Care Med 2006 32 1039 1044 10.1007/s00134-006-0171-0 16791666 Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study Boumendil A Aegerter P Guidet B J Am Geriatr Soc 2005 53 88 93 10.1111/j.1532-5415.2005.53016.x 15667382 Functional abilities of elderly survivors of intensive care Broslawski GE Elkins M Algus M J Am Osteopath Assoc 1995 95 712 717 8557555 Opinions about surrogate designation: a population survey in France Azoulay E Pochard F Chevret S Adrie C Bollaert PE Brun F Dreyfuss D Garrouste-Orgeas M Goldgran-Toledano D Jourdain M Wolff M Le Gall JR Schlemmer B Crit Care Med 2003 31 1711 1714 10.1097/01.CCM.0000069828.15555.09 12794409 Triaging patients to the ICU: a pilot study of factors influencing admission decisions and patient outcomes Garrouste-Orgeas M Montuclard L Timsit JF Misset B Christias M Carlet J Intensive Care Med 2003 29 774 781 12677368 Inconsistency over time in the preferences of older persons with advanced illness for life-sustaining treatment Fried TR O'Leary J Van Ness P Fraenkel L J Am Geriatr Soc 2007 55 1007 1014 10.1111/j.1532-5415.2007.01232.x 1948955 17608872 Stability of choices about life-sustaining treatments Danis M Garrett J Harris R Patrick DL Ann Intern Med 1994 120 567 573 8116994 What would Terri want? On the psychological challenges of surrogate decision making Ditto PH Death Stud 2006 30 135 148 10.1080/07481180500455624 16404818 Prospective study of health status preferences and changes in preferences over time in older adults Fried TR Byers AL Gallo WT Van Ness PH Towle VR O'Leary JR Dubin JA Arch Intern Med 2006 166 890 895 10.1001/archinte.166.8.890 1978221 16636215 Preferences for mechanical ventilation among survivors of prolonged mechanical ventilation and tracheostomy Guentner K Hoffman LA Happ MB Kim Y Dabbs AD Mendelsohn AB Chelluri L Am J Crit Care 2006 15 65 77 16391316