1532-429X-13-S1-P111532-429X Poster presentation <p>Free-breathing myocardial T2 measurements at 1.5T</p> LohezicMaelene MeniniAnne EscanyéJean-Marie MariePierre-Yves MandryDamien VuissozPierre-André FelblingerJacques

GE Healthcare / IADI Lab, Nancy, France

INSERM U947, Nancy, France

Nancy-Université, Nancy, France

CHU Nancy, Nancy, France

Journal of Cardiovascular Magnetic Resonance <p>Abstracts of the 2011 SCMR/Euro CMR Joint Scientific Sessions</p> Meeting abstracts - A single PDF containing all abstracts in this supplement is available here. <p>2011 SCMR/Euro CMR Joint Scientific Sessions</p> Nice, France 3-6 February 2011 http://www.scmr.org/ 1532-429X 2011 13 Suppl 1 P11 http://jcmr-online.com/content/13/S1/P11 10.1186/1532-429X-13-S1-P11
222011 2011Lohezic et al; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Introduction

Myocardial T2 mapping is a valuable tool for tissue characterization and oedema visualization. For instance, it is used to detect early rejection of heart transplant 1 . T2 values are usually estimated by performing several black blood Fast Spin Echo (FSE) sequences with different Echo Times (TE), what requires multiple breath holds. Successive apneas could lead to misregistration between images and to patient discomfort. A method allowing free breathing myocardial T2 measurements has been recently proposed and evaluated at 3T 2 . Results at 1.5T are presented here.

Purpose

This study aims at demonstrating the feasibility of free-breathing myocardial T2 mapping at 1.5T.

Methods

MRI experiments

Five healthy volunteers underwent cardiac examination at 1.5T (SIGNA HDxt, GE Healthcare, Milwaukee, WI). Two sets of ten images with different TE were acquired with a conventional cardiac-gated black blood FSE sequence at mid-cavity short axis view, one during breath hold and the other one during free breathing. The same parameters were used, except for echo train length (ETL) (Table 1).ETL was set at 24 to keep the breath hold duration short, whereas 16 echoes were used for free-breathing acquisitions. Raw data from the free breathing acquisitions were recorded. Signals from a respiratory belt were carried by a custom Maglife patient monitoring system (Schiller Medical, France) and recorded with a dedicated home-made hardware 3 .

<p>Table 1</p>

Acqusition parameters

TE

10 to 75 ms

TR

2RR

TI

500 ms

Matrix size

128X128

FOV

36 cm

BW

62.5kHz

Slice thickness

10mm

ETL

16 or 24

Post-processing

First, the ten breath-held images were registered manually. Then, the T2 map was obtained using a mono-exponential model to fit the T2 signal versus the echo time decay curve, on a pixel-wise basis.

Free breathing reconstruction

Using physiological signals extracted from the respiratory belt, the method presented in 2 was used to obtain an artefact-free proton density weighted image r0 and a T2 map from the free breathing raw data set. For the sake of comparison, six segments were drawn on the left ventricle myocardium. The mean value of each ROI was then used to get 6 myocardial T2 values.

Results

Like at 3T, there was no significant differences between the two sets of myocardial T2 values (paired Student T-test, p=0.17). The free breathing T2 maps were in good agreement with the breath-held ones and respiratory artefacts were widely reduced in r0 (Fig. 1).

<p>Figure 1</p>

T2 maps obtained on one volunteer in breath hold (left) and in free breathing (right)

T2 maps obtained on one volunteer in breath hold (left) and in free breathing (right)

Conclusions

The proposed free breathing method allows performing accurate T2 mapping at 1.5T with no additional acquisition time.

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