Potential for a global dynamic of Influenza A (H1N1).

Abstract : BACKGROUND: Geographical and temporal diffusion patterns of a human pandemic due to Swine Origin Influenza Virus (S-OIV) remain uncertain. The extent to which national and international pandemic preparedness plans and control strategies can slow or stop the process is not known. However, despite preparedness efforts, it appears that, particularly in the USA, Mexico, Canada and the UK, local chains of virus transmission can sustain autonomous dynamics which may lead to the next pandemic. Forecasts of influenza experts usually rely on information related to new circulating strains. METHODS: We attempted to quantify the possible spread of the pandemic across a network of 52 major cities and to predict the effect of vaccination against the pandemic strain, if available. Predictions are based on simulations from a stochastic SEIR model. Parameters used in the simulations are set to values consistent with recent estimations from the outbreak in Mexico. RESULTS: We show that a two-wave pandemic dynamic may be observed in Southern hemisphere because of seasonal constraints for a maximum value of the basic reproductive number (R0, max) within a city equal to 1.5 and a mean generation interval (GI) of 2 days. In this case and in the absence of vaccination, attack rates may reach 46% when considering a completely susceptible population. More severe scenarios characterized by higher values of R0, max (2.2) and GI (3.1) yield an attack rate of 77%. By extrapolation, we find that mass vaccination in all countries (i.e. up to 50% of the population) implemented 6 months after the start of the pandemic may reduce the cumulative number of cases by 91% in the case of the low transmissible strain (R0, max = 1.5). This relative reduction is only 44% for R0, max = 2.2 since most of the cases occur in the first 6 months and so before the vaccination campaign. CONCLUSION: Although uncertainties remain about the epidemiological and clinical characteristics of the new influenza strain, this study provides the first analysis of the potential spread of the pandemic and first assessment of the impact of different immunization strategies.
Type de document :
Article dans une revue
BMC Infectious Diseases, BioMed Central, 2009, 9 (1), pp.129. 〈10.1186/1471-2334-9-129〉
Liste complète des métadonnées

Littérature citée [8 références]  Voir  Masquer  Télécharger

Contributeur : Ed. Bmc <>
Soumis le : vendredi 27 janvier 2012 - 13:46:23
Dernière modification le : mercredi 21 mars 2018 - 18:57:26
Document(s) archivé(s) le : mercredi 14 décembre 2016 - 01:30:18





Antoine Flahault, Elisabeta Vergu, Pierre-Yves Boëlle. Potential for a global dynamic of Influenza A (H1N1).. BMC Infectious Diseases, BioMed Central, 2009, 9 (1), pp.129. 〈10.1186/1471-2334-9-129〉. 〈inserm-00663615〉



Consultations de la notice


Téléchargements de fichiers