In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure

Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment.

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Cardiologie et système cardiovasculaire Neurobiologie

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https://inserm.hal.science/inserm-00663532

Soumis le : vendredi 27 janvier 2012-13:03:18

Dernière modification le : lundi 18 mars 2024-12:54:13

Archivage à long terme le : lundi 19 novembre 2012-14:55:09

Dates et versions

inserm-00663532 , version 1 (27-01-2012)

Identifiants

HAL Id : inserm-00663532 , version 1
DOI : 10.1186/2040-7378-2-4
PUBMED : 20298536

Citer

Fabien Chauveau, Samir Moucharrafie, Marlène Wiart, Jean-Christophe Brisset, Yves Berthezène, et al.. In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure. Experimental & Translational Stroke Medicine, 2010, 2 (1), pp.4. ⟨10.1186/2040-7378-2-4⟩. ⟨inserm-00663532⟩

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