Analyse rétrospective de 24 glioblastomes récidivant après radiochimiothérapie concomitante et traités par nitrosourées ou par l'association irinotécan et bévacizumab. [Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].

Abstract : Despite progress in the initial management of glioblastoma (GB), the vast majority of patients will experience recurrence within 2-3 years. The medical treatment of these recurrences is being modified by the use of antiangiogenic therapies. Twenty-four patients, who relapsed from GB after chemoradiation followed by adjuvant temozolomide in Rennes, were treated by conventional chemotherapy (nitrosourea) or by the combination of irinotecan and bevacizumab. In this retrospective analysis, overall survival from diagnosis of recurrence was significantly longer in patients treated with the combination of bevacizumab and irinotecan than with nitrosourea (5 months versus 11.5 months). The combination of irinotecan and bevacizumab appeared to provide clinical benefit to patients with recurrent GB.
Type de document :
Article dans une revue
Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (2), pp.121-6. 〈10.1684/bdc.2011.1528〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00662493
Contributeur : Hervé De Villemeur <>
Soumis le : mardi 24 janvier 2012 - 11:59:36
Dernière modification le : mercredi 21 février 2018 - 01:36:54

Identifiants

Collections

Citation

Elodie Vauleon, Habiba Mesbah, Daniel Gedouin, Isabelle Lecouillard, Guillaume Louvel, et al.. Analyse rétrospective de 24 glioblastomes récidivant après radiochimiothérapie concomitante et traités par nitrosourées ou par l'association irinotécan et bévacizumab. [Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].. Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (2), pp.121-6. 〈10.1684/bdc.2011.1528〉. 〈inserm-00662493〉

Partager

Métriques

Consultations de la notice

582