Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?: SPM-derived hippocampal measurements

Abstract : BACKGROUND AND PURPOSE: To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD). METHODS: T1-MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole-brain analysis, or using a template region of interest-ROI-approach) were compared to the gold-standard individual ROI (ROI-i) method through 2 statistical approaches (ANOVA and Pearson's R). RESULTS: First, whole-brain analyses performed on modulated data are as sensitive as the ROI-i approach in detecting aMCI patients' hippocampal atrophy. Second, values extracted from the ROI-template applied to modulated data provide measures of hippocampal volume comparable to those obtained using the ROI-i approach. CONCLUSIONS: This study provides guidance on how to extract accurate hippocampal measures from VBM-derived data in early AD, as a time-saving and easy alternative to the reference ROI-i method.
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J. Neuroimaging, 2011, 21 (4), pp.310-6. 〈10.1111/j.1552-6569.2010.00548.x〉
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http://www.hal.inserm.fr/inserm-00646697
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Katell Mevel, Béatrice Desgranges, Jean-Claude Baron, Brigitte Landeau, Vincent De La Sayette, et al.. Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?: SPM-derived hippocampal measurements. J. Neuroimaging, 2011, 21 (4), pp.310-6. 〈10.1111/j.1552-6569.2010.00548.x〉. 〈inserm-00646697〉

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