Autologous bone marrow cells and ischemic cardiomyopathy.

Abstract : Evaluation of: Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. Circ. Res. 108, 792-796 (2011). Transcatheter, intramyocardial injections of bone marrow-derived cells produce reverse remodeling in large animal models of ischemic cardiomyopathy. A variety of adult stem and progenitor cells from different sources have already been examined for their potential to promote cardiac repair and regeneration after myocardial infarction. This article reviews a recent study by Williams et al. who test the hypothesis that transcatheter, intramyocardial injections of autologous bone marrow progenitor cells (mononuclear or mesenchymal stem cells) in left ventricular scar and border zone improve regional contractility of a chronic myocardial scar and that these changes predict subsequent reverse remodeling. All patients tolerated the procedure with no serious adverse events. At 1 year, cardiac MRI demonstrated a decrease in end diastolic volume, a trend toward decreased end systolic volume, decreased infarct size and improved regional left ventricular function. This article focuses on the findings and limitations of the study and provides an insight for future promising clinical trials.
Type de document :
Article dans une revue
Future Cardiology, Future Medicine, 2011, 7 (5), pp.603-7. 〈10.2217/fca.11.46〉
Liste complète des métadonnées

Littérature citée [7 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00642809
Contributeur : Patricia Lemarchand <>
Soumis le : samedi 1 septembre 2012 - 07:01:00
Dernière modification le : lundi 25 juin 2018 - 09:33:45
Document(s) archivé(s) le : dimanche 2 décembre 2012 - 02:30:08

Fichiers

PPE_FUTURE_CARDIOLOGY_RONCALLI...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Jérôme Roncalli, Patricia Lemarchand. Autologous bone marrow cells and ischemic cardiomyopathy.. Future Cardiology, Future Medicine, 2011, 7 (5), pp.603-7. 〈10.2217/fca.11.46〉. 〈inserm-00642809〉

Partager

Métriques

Consultations de la notice

260

Téléchargements de fichiers

182