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(Vitamin B6 and cancer: from clinical data to molecularly mechanisms).
Sujol G., Docquier A., Boulahtouf A., Castet-Nicolas A., Cavaillès V.
Bulletin du Cancer 98, 10 (2011) 1201-8 - http://www.hal.inserm.fr/inserm-00636035
(22001823)
[Vitamin B6 and cancer: from clinical data to molecularly mechanisms].
Guillaume Sujol1, Aurélie Docquier1, Abdelhay Boulahtouf1, Audrey Castet-Nicolas1, 2, Vincent Cavaillès () 1
1 :  IRCM - Institut de recherche en cancérologie de Montpellier
INSERM : U896 – Université Montpellier I – CRLCC Val d'Aurelle - Paul Lamarque
208 rue des Apothicaires F-34298 Montpellier
France
2 :  Pharmacie Hôpital Lapeyronie
http://www.chu-montpellier.fr/
CHRU Montpellier – Université Montpellier I
371, avenue du Doyen Gaston Giraud 34295 Montpellier Cedex 5
France
Vitamine B6 et cancer
Vitamin B6 is well-known for its role as a cofactor in many enzymatic reactions and recently, several epidemiological studies have highlighted the importance of this vitamin as a protective agent against various cancers: elevated vitamin B6 plasma levels were associated with a lower risk of colorectal cancer development, for example. In vivo studies have shown that vitamin B6 decreased cell proliferation and enhanced the immune response. At the cellular level, antioxidant, pro-apoptotic and anti-angiogenic effects have been identified. At the molecular level, vitamin B6 is able to inhibit the transactivation potential of various nuclear receptors. Interestingly, a recent paper has described the conjugation of vitamin B6 to RIP140 (receptor interacting protein of 140 kDa), a protein that acts as a transcriptional corepressor of nuclear receptors. This post-translational modification increases the transcriptional repression of RIP140 and regulates its subcellular localization and its ability to interact with different protein partners. Finally, vitamin B6 is involved in the methyl donor cycle ant thus, some of the antitumor properties of vitamin B6 may involve an indirect effect on the level of DNA or histone methylation. All of these mechanistic and clinical data justify further studies to decipher the mechanism of action of vitamin B6 and its clinical interest in combination with molecules typically used in chemotherapy or hormonal therapy.
Sciences du Vivant/Cancérologie
Sciences du Vivant/Pharmacologie/Médicaments
Sciences du Vivant/Santé publique et épidémiologie
Français
0007-4551

Articles dans des revues avec comité de lecture
10.1684/bdc.2011.1458
Bulletin du Cancer (Bull Cancer)
Publisher John Libbey Eurotext
ISSN 0007-4551 (eISSN : 1769-6917)
internationale
01/10/2011
14/10/2011
98
10
1201-8

vitamine B6 – cancer – expression génique – modifications post-traductionnelles – épigénétique – transcription
Adaptor Proteins – Signal Transducing – Animals – Colorectal Neoplasms – DNA Methylation – Epigenesis – Genetic – Histones – Humans – Neoplasm Proteins – Neoplasms – Nuclear Proteins – Protein Processing – Post-Translational – Rats – Receptors – Cytoplasmic and Nuclear – Vitamin B 6
Les travaux du laboratoire sur la vitamine B6 sont soutenus par l'Institut National de la Santé et de la Recherche Médicale, l'Université de Montpellier 1, l'Association pour la Recherche sur le Cancer, l'Institut National du Cancer, l'Association Le cancer du sein, parlons-en !, la Ligue contre le Cancer.
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