Some control samples were collected as part of a genetic study of schizophrenia (Gejman PI) Data and biomaterials from the NIMH GI (Genetics Initiative) MGS2 (Molecular Genetics of Schizophrenia) control sample were collected by NorthShore University HealthSystemCollaboration Coordinator; PI) as part of a collaborative R01 application comprised of ten sites. FromCollaboration Coordinator; PI Emory University School of Medicine University of CaliforniaPI), calculated using Hapmap2: rs736408, rs12576775 and HapMap3: rs10994397 the Principal Investigators and Co-Investigators were: NorthShore University HealthSystem J. Mowry, M.D. (PI); Mt. Sinai School of Medicine Ph.D. (PI), 2003. ,
grateful to all patients who contributed to this study We also thank all probands from the community-based cohorts of PopGen, KORA, and the Heinz Nixdorf Recall (HNR) study. This study was supported by the German Federal Ministry of Education and Research (BMBF), within the context of the, NGFN-2), the National Genome Research Network plus (NGFNplus), and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to S.C. and M.M.N., grant 01GS08147 to M.R.). M.M.N. also received support from the Alfried Krupp von Bohlen und Halbach-Stiftung ,
For best estimate diagnostic work, we thank Vegas, For data management we thank Mariano Erpe and for study coordination Carrie Fisher, R.N ,
University of Massachusetts Medical Center (Jayendra Patel, M.D.); University of Oklahoma College of Medicine (Mark D. Fossey, M.D.); University of Pennsylvania Medical Center Collection of DNA from consenting participants in STEP-BD was supported by Sample collection funding was supported by NIH grants, University of Pittsburgh Western Psychiatric Institute and Clinic, pp.1-80001 ,
Genotyping was funded by grants from NIH (MH067288 Pamela Sklar, PI), Johnson & Johnson Pharmaceutical Research and Development, Sylvan C. Herman Foundation, Medical Research Foundation, and Merck Genome Research Institute ,
Whole-genome association study of bipolar disorder, Molecular Psychiatry, vol.17, issue.6, pp.558-69, 2008. ,
DOI : 10.1038/ng1706
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder, Nature Genetics, vol.79, issue.9, 2008. ,
DOI : 10.1016/j.biopsych.2005.12.008
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry, Proceedings of the National Academy of Sciences, vol.106, issue.18, pp.7501-7507, 2009. ,
DOI : 10.1073/pnas.0813386106
Genome-wide association study of bipolar disorder in European American and African American individuals, Molecular Psychiatry, vol.155, issue.8, pp.755-63, 2009. ,
DOI : 10.1038/456018a
A genome side association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample, J Affect Disord in press, 2010. ,
Structured Clinical Interview for DSM-IV Axis I Disorders, 1996. ,
Research Diagnostic Criteria, Archives of General Psychiatry, vol.35, issue.6, pp.773-782, 1978. ,
DOI : 10.1001/archpsyc.1978.01770300115013
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder, Molecular Psychiatry, vol.69, issue.2, pp.197-207, 2008. ,
DOI : 10.1016/j.cell.2006.03.032
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder, Molecular Psychiatry, vol.60, issue.5, pp.487-91, 2009. ,
DOI : 10.1523/JNEUROSCI.4314-05.2006
Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement, Molecular Psychiatry, vol.447, issue.5, pp.466-473, 2008. ,
DOI : 10.1086/512133
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21, Nat Genet, vol.1, issue.42, pp.128-159 ,
Genome-wide Association Study of Alcohol Dependence, Archives of General Psychiatry, vol.66, issue.7, pp.773-84, 2009. ,
DOI : 10.1001/archgenpsychiatry.2009.83
Gene variants associated with schizophrenia in a Norwegian genomewide study are replicated in a large European cohort ISC. Rare chromosomal deletions and duplications increase risk of schizophrenia, J Psychiatr Res. Nature, vol.15, issue.455, pp.237-278, 2008. ,
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1), Biological Psychiatry, vol.57, issue.7 ,
DOI : 10.1016/j.biopsych.2005.01.018
The Structured Clinical Interview for DSM-III-R (SCID), Archives of General Psychiatry, vol.49, issue.8, pp.624-633, 1992. ,
DOI : 10.1001/archpsyc.1992.01820080032005
Diagnostic Interview for Genetic Studies, Archives of General Psychiatry, vol.51, issue.11, pp.849-59, 1994. ,
DOI : 10.1001/archpsyc.1994.03950110009002
SCAN, Archives of General Psychiatry, vol.47, issue.6, pp.589-93, 1990. ,
DOI : 10.1001/archpsyc.1990.01810180089012
URL : https://hal.archives-ouvertes.fr/inserm-00521391
The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10, J Clin Psychiatry, vol.59, issue.20, pp.22-33, 1998. ,
Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering, The American Journal of Human Genetics, vol.81, issue.5 ,
DOI : 10.1086/521987
Genomic Control for Association Studies, Biometrics, vol.280, issue.4, pp.997-1004, 1999. ,
DOI : 10.1111/j.0006-341X.1999.00997.x
Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: Rationale and design of the Heinz Nixdorf RECALL Study, American Heart Journal, vol.144, issue.2, pp.212-220, 2002. ,
DOI : 10.1067/mhj.2002.123579
Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort, Psychiatric Genetics, vol.19, issue.5, pp.244-52, 2009. ,
DOI : 10.1097/YPG.0b013e32832ceea9
Characteristics of Bipolar Disorder in an Australian Specialist Outpatient Clinic: Comparison Across Large Datasets, Australian & New Zealand Journal of Psychiatry, vol.11, issue.422, pp.109-126, 2009. ,
DOI : 10.1192/bjp.133.5.429
The Schedule for Affective Disorder and Schizophrenia, Lifetime Version, 1977. ,