G. Simonneau, I. Robbins, M. Beghetti, R. Channick, M. Delcroix et al., Updated Clinical Classification of Pulmonary Hypertension, Journal of the American College of Cardiology, vol.54, issue.1, pp.43-54, 2009.
DOI : 10.1016/j.jacc.2009.04.012

Z. Deng, J. Morse, S. Slager, N. Cuervo, K. Moore et al., Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor???II Gene, The American Journal of Human Genetics, vol.67, issue.3, pp.737-744, 2000.
DOI : 10.1086/303059

R. Trembath, J. Thomson, R. Machado, N. Morgan, C. Atkinson et al., Clinical and Molecular Genetic Features of Pulmonary Hypertension in Patients with Hereditary Hemorrhagic Telangiectasia, New England Journal of Medicine, vol.345, issue.5, pp.325-334, 2001.
DOI : 10.1056/NEJM200108023450503

S. Bonnet, E. Michelakis, C. Porter, M. Andrade-navarro, B. Thébaud et al., An Abnormal Mitochondrial-Hypoxia Inducible Factor-1??-Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension, Circulation, vol.113, issue.22, pp.2630-2641, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.609008

C. Cool, D. Kennedy, N. Voelkel, and R. Tuder, Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection, Human Pathology, vol.28, issue.4, pp.434-442, 1997.
DOI : 10.1016/S0046-8177(97)90032-0

R. Tuder, B. Groves, D. Badesch, and N. Voelkel, Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension, Am J Pathol, vol.144, pp.275-285, 1994.

P. Dorfmüller, M. Humbert, F. Perros, O. Sanchez, G. Simonneau et al., Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases, Human Pathology, vol.38, issue.6, pp.893-902, 2007.
DOI : 10.1016/j.humpath.2006.11.022

F. Perros, P. Dorfmüller, R. Souza, I. Durand-gasselin, S. Mussot et al., Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension, European Respiratory Journal, vol.29, issue.3, pp.462-468, 2007.
DOI : 10.1183/09031936.00094706

K. Balabanian, A. Foussat, P. Dorfmüller, I. Durand-gasselin, F. Capel et al., C Chemokine Fractalkine in Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.165, issue.10, pp.1419-1425, 2002.
DOI : 10.1164/rccm.2106007

P. Dorfmuller, V. Zarka, I. Durand-gasselin, G. Monti, K. Balabanian et al., Chemokine RANTES in Severe Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.165, issue.4, pp.534-539, 2002.
DOI : 10.1164/ajrccm.165.4.2012112

M. Humbert, G. Monti, F. Brenot, O. Sitbon, A. Portier et al., Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension., American Journal of Respiratory and Critical Care Medicine, vol.151, issue.5, pp.1628-1631, 1995.
DOI : 10.1164/ajrccm.151.5.7735624

F. Perros, D. Montani, P. Dorfmüller, I. Durand-gasselin, C. Tcherakian et al., Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.178, issue.1, pp.81-88, 2008.
DOI : 10.1164/rccm.200707-1037OC

K. Satoh, P. Nigro, T. Matoba, O. Dell, M. Cui et al., Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II???induced aortic aneurysms, Nature Medicine, vol.24, issue.6, pp.649-656, 2009.
DOI : 10.1038/nm.1958

J. Beckman and W. Koppenol, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly, Am J Physiol, vol.271, pp.1424-1437, 1996.

K. Irani, Oxidant Signaling in Vascular Cell Growth, Death, and Survival : A Review of the Roles of Reactive Oxygen Species in Smooth Muscle and Endothelial Cell Mitogenic and Apoptotic Signaling, Circulation Research, vol.87, issue.3, pp.179-183, 2000.
DOI : 10.1161/01.RES.87.3.179

K. Satoh, T. Matoba, J. Suzuki, O. Dell, M. Nigro et al., Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation, Circulation, vol.117, issue.24, pp.3088-3098, 2008.
DOI : 10.1161/CIRCULATIONAHA.107.756106

G. Millonig, H. Niederegger, W. Rabl, B. Hochleitner, D. Hoefer et al., Network of Vascular-Associated Dendritic Cells in Intima of Healthy Young Individuals, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.21, issue.4, pp.503-508, 2001.
DOI : 10.1161/01.ATV.21.4.503

P. Silacci, A. Desgeorges, L. Mazzolai, C. Chambaz, and D. Hayoz, Flow Pulsatility Is a Critical Determinant of Oxidative Stress in Endothelial Cells, Hypertension, vol.38, issue.5, pp.1162-1166, 2001.
DOI : 10.1161/hy1101.095993

W. Zhu, S. Li, L. Lin, H. Yan, T. Fu et al., Vascular oxidative stress increases dendritic cell adhesion and transmigration induced by homocysteine, Cellular Immunology, vol.254, issue.2, pp.110-116, 2009.
DOI : 10.1016/j.cellimm.2008.08.001

R. Bowers, C. Cool, R. Murphy, R. Tuder, M. Hopken et al., Oxidative Stress in Severe Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.169, issue.6, pp.764-769, 2004.
DOI : 10.1164/rccm.200301-147OC

K. Okada, Y. Tanaka, M. Bernstein, W. Zhang, G. Patterson et al., Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension, Am J Pathol, vol.151, pp.1019-1025, 1997.
DOI : 10.1378/chest.114.1_supplement.7s

M. Juremalm, M. Hjertson, N. Olsson, I. Harvima, K. Nilsson et al., The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1?? acts as a mast cell chemotaxin, European Journal of Immunology, vol.292, issue.12, pp.3614-3622, 2000.
DOI : 10.1002/1521-4141(200012)30:12<3614::AID-IMMU3614>3.0.CO;2-B

V. Godot, M. Arock, G. Garcia, F. Capel, C. Flys et al., H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12, Journal of Allergy and Clinical Immunology, vol.120, issue.4, pp.827-834, 2007.
DOI : 10.1016/j.jaci.2007.05.046

URL : https://hal.archives-ouvertes.fr/hal-00172552

D. Montani, F. Perros, N. Gambaryan, B. Girerd, P. Dorfmuller et al., C-Kit???Positive Cells Accumulate in Remodeled Vessels of Idiopathic Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.184, issue.1, 2011.
DOI : 10.1164/rccm.201006-0905OC

D. Heath and M. Yacoub, Lung mast cells in plexogenic pulmonary arteriopathy., Journal of Clinical Pathology, vol.44, issue.12, pp.1003-1006, 1991.
DOI : 10.1136/jcp.44.12.1003

B. Dahal, D. Kosanovic, C. Kaulen, T. Cornitescu, R. Savai et al., Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats, Respiratory Research, vol.42, issue.1, p.60, 2011.
DOI : 10.1111/j.1749-6632.1968.tb15186.x

J. Hoffmann, J. Yin, M. Kukucka, N. Yin, I. Saarikko et al., Mast cells promote lung vascular remodelling in pulmonary hypertension, European Respiratory Journal, vol.37, issue.6, pp.1400-1410, 2011.
DOI : 10.1183/09031936.00043310

D. Keulenaer, G. Chappell, D. Ishizaka, N. Nerem, R. Alexander et al., Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State : Role of a Superoxide-Producing NADH Oxidase, Circulation Research, vol.82, issue.10, pp.1094-1101, 1998.
DOI : 10.1161/01.RES.82.10.1094

J. Ravensbergen, J. Ravensbergen, J. Krijger, B. Hillen, and H. Hoogstraten, Localizing Role of Hemodynamics in Atherosclerosis in Several Human Vertebrobasilar Junction Geometries, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.18, issue.5, pp.708-716, 1998.
DOI : 10.1161/01.ATV.18.5.708

. Dorfmüller, http://respiratory-research.com/content, Respiratory Research, vol.12121, p.119119, 2011.

A. Wagner, O. Kautz, K. Fricke, M. Zerr-fouineau, E. Demicheva et al., Upregulation of Glutathione Peroxidase Offsets Stretch-Induced Proatherogenic Gene Expression in Human Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.29, issue.11, pp.1894-1901, 2009.
DOI : 10.1161/ATVBAHA.109.194738

F. Ali, M. Zakkar, K. Karu, E. Lidington, S. Hamdulay et al., Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow, Journal of Biological Chemistry, vol.284, issue.28, pp.18882-18892, 2009.
DOI : 10.1074/jbc.M109.009886

E. Porteri, L. Rodella, R. Rezzani, D. Rizzoni, S. Paiardi et al., Role of Heme Oxygenase in Modulating Endothelial Function in Mesenteric Small Resistance Arteries of Spontaneously Hypertensive Rats, Clinical and Experimental Hypertension, vol.261, issue.6, pp.560-571, 2009.
DOI : 10.1046/j.1365-2826.1998.00266.x

H. Yu, T. Hwang, Y. C. Lau, and Y. , Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway, Critical Care Medicine, vol.38, issue.4, pp.1147-1154, 2010.
DOI : 10.1097/CCM.0b013e3181cd124e

A. Loboda, A. Stachurska, U. Florczyk, D. Rudnicka, A. Jazwa et al., HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells, Antioxidants & Redox Signaling, vol.11, issue.7, pp.1501-1517, 2009.
DOI : 10.1089/ars.2008.2211

G. Semenza, Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology, Chest, vol.128, issue.6, pp.592-594, 2005.
DOI : 10.1378/chest.128.6_suppl.592S

Q. Zhang, D. Bellotto, P. Ravikumar, O. Moe, R. Hogg et al., Postpneumonectomy lung expansion elicits hypoxia-inducible factor-1?? signaling, AJP: Lung Cellular and Molecular Physiology, vol.293, issue.2, pp.497-504, 2007.
DOI : 10.1152/ajplung.00393.2006

A. Podlutsky, P. Ballabh, and A. Csiszar, Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats, AJP: Heart and Circulatory Physiology, vol.298, issue.2, pp.346-351, 2010.
DOI : 10.1152/ajpheart.00972.2009

S. Wind, K. Beuerlein, M. Armitage, A. Taye, A. Kumar et al., Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition, Hypertension, vol.56, issue.3, pp.490-497, 2010.
DOI : 10.1161/HYPERTENSIONAHA.109.149187

N. Davie, E. Gerasimovskaya, S. Hofmeister, A. Richman, P. Jones et al., Pulmonary Artery Adventitial Fibroblasts Cooperate with Vasa Vasorum Endothelial Cells to Regulate Vasa Vasorum Neovascularization, The American Journal of Pathology, vol.168, issue.6, pp.1793-1807, 2006.
DOI : 10.2353/ajpath.2006.050754

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606613

S. Li, S. Tabar, V. Malec, B. Eul, W. Klepetko et al., NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts, Antioxidants & Redox Signaling, vol.10, issue.10, pp.41687-1698, 2008.
DOI : 10.1089/ars.2008.2035

S. Ismail, A. Sturrock, P. Wu, B. Cahill, K. Norman et al., NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-??1 and insulin-like growth factor binding protein-3, AJP: Lung Cellular and Molecular Physiology, vol.296, issue.3, pp.489-499, 2009.
DOI : 10.1152/ajplung.90488.2008

H. Esterbauer, J. Gebicki, H. Puhl, and G. Jürgens, The role of lipid peroxidation and antioxidants in oxidative modification of LDL, Free Radical Biology and Medicine, vol.13, issue.4, pp.341-390, 1992.
DOI : 10.1016/0891-5849(92)90181-F

M. Beal, Oxidatively modified proteins in aging and disease1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on ???Oxidatively Modified Proteins in Aging and Disease.??? The full list of papers may be found on the homepage of the journal., Free Radical Biology and Medicine, vol.32, issue.9, pp.797-803, 2002.
DOI : 10.1016/S0891-5849(02)00780-3

J. Cadet, S. Bellon, M. Berger, A. Bourdat, T. Douki et al., Recent Aspects of Oxidative DNA Damage: Guanine Lesions, Measurement and Substrate Specificity of DNA Repair Glycosylases, Biological Chemistry, vol.383, issue.6, pp.933-943, 2002.
DOI : 10.1515/BC.2002.100

D. Miguel, C. Guo, C. Lund, H. Feng, D. Mattson et al., Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease, AJP: Renal Physiology, vol.300, issue.3, 2010.
DOI : 10.1152/ajprenal.00454.2010

P. Dorfmuller, F. Perros, K. Balabanian, and M. Humbert, Inflammation in pulmonary arterial hypertension, European Respiratory Journal, vol.22, issue.2, pp.358-363, 2003.
DOI : 10.1183/09031936.03.00038903

Y. Furuya, T. Satoh, and M. Kuwana, Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension, International Journal of Rheumatology, vol.145, issue.2, p.720305, 2010.
DOI : 10.1136/thx.2006.064097

M. Steiner, O. Syrkina, N. Kolliputi, E. Mark, C. Hales et al., Interleukin-6 Overexpression Induces Pulmonary Hypertension, Circulation Research, vol.104, issue.2, pp.236-244, 2009.
DOI : 10.1161/CIRCRESAHA.108.182014

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.561.7740

C. Speyer, H. Gao, N. Rancilio, T. Neff, G. Huffnagle et al., Novel Chemokine Responsiveness and Mobilization of Neutrophils during Sepsis, The American Journal of Pathology, vol.165, issue.6, pp.2187-2196, 2004.
DOI : 10.1016/S0002-9440(10)63268-3

J. Oppenheim, C. Zachariae, N. Mukaida, and K. Matsushima, Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family, Annual Review of Immunology, vol.9, issue.1, pp.617-648, 1991.
DOI : 10.1146/annurev.iy.09.040191.003153

Y. Zhang, J. Lin, and J. Vilcek, Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP, J Biol Chem, vol.263, pp.6177-6182, 1988.

N. Voelkel, R. Tuder, J. Bridges, and W. Arend, Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline., American Journal of Respiratory Cell and Molecular Biology, vol.11, issue.6, pp.664-675, 1994.
DOI : 10.1165/ajrcmb.11.6.7946395

H. El-haroun, D. Clarke, K. Deacon, D. Bradbury, A. Clayton et al., IL-1??, BK, and TGF-??1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA, AJP: Lung Cellular and Molecular Physiology, vol.294, issue.3, pp.553-562, 2008.
DOI : 10.1152/ajplung.00044.2006

F. Fischer, Y. Luo, M. Luo, L. Santambrogio, and M. Dorf, RANTES-Induced Chemokine Cascade in Dendritic Cells, The Journal of Immunology, vol.167, issue.3, pp.1637-1643, 2001.
DOI : 10.4049/jimmunol.167.3.1637

L. Long, A. Crosby, X. Yang, M. Southwood, P. Upton et al., Altered Bone Morphogenetic Protein and Transforming Growth Factor-?? Signaling in Rat Models of Pulmonary Hypertension: Potential for Activin Receptor-Like Kinase-5 Inhibition in Prevention and Progression of Disease, Circulation, vol.119, issue.4, pp.566-576, 2009.
DOI : 10.1161/CIRCULATIONAHA.108.821504

Y. Tanaka, D. Schuster, E. Davis, G. Patterson, and M. Botney, The role of vascular injury and hemodynamics in rat pulmonary artery remodeling., Journal of Clinical Investigation, vol.98, issue.2, pp.434-442, 1996.
DOI : 10.1172/JCI118809

N. Homma, T. Nagaoka, V. Karoor, M. Imamura, L. Taraseviciene-stewart et al., Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone, AJP: Lung Cellular and Molecular Physiology, vol.295, issue.1
DOI : 10.1152/ajplung.90251.2008

L. Cras, T. Fernandez, L. Pastura, P. Laubach, and V. , Vascular growth and remodeling in compensatory lung growth following right lobectomy, Journal of Applied Physiology, vol.98, issue.3, pp.1140-1148, 2005.
DOI : 10.1152/japplphysiol.00479.2004

J. Banchereau and R. Steinman, Dendritic cells and the control of immunity, Nature, vol.392, issue.6673, pp.245-252, 1998.
DOI : 10.1038/32588

J. Tan, O. Neill, and H. , Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity, Journal of Leukocyte Biology, vol.78, issue.2, pp.319-324, 2005.
DOI : 10.1189/jlb.1104664

Y. Bobryshev, Dendritic cells in atherosclerosis: current status of the problem and clinical relevance, European Heart Journal, vol.26, issue.17, pp.1700-1704, 2005.
DOI : 10.1093/eurheartj/ehi282

A. Rivollier, L. Perrin-cocon, S. Luche, H. Diemer, J. Strub et al., High Expression of Antioxidant Proteins in Dendritic Cells: Possible Implications in Atherosclerosis, Molecular & Cellular Proteomics, vol.5, issue.4, pp.726-736, 2006.
DOI : 10.1074/mcp.M500262-MCP200

URL : https://hal.archives-ouvertes.fr/hal-00115847

I. Heier, K. Malmström, A. Sajantila, J. Lohi, M. Mäkelä et al., Characterisation of bronchus-associated lymphoid tissue and antigenpresenting cells in central airway mucosa of children, Thorax, 2010.

J. Rangel-moreno, L. Hartson, C. Navarro, M. Gaxiola, M. Selman et al., Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis, Journal of Clinical Investigation, vol.116, issue.12, pp.3183-3194, 2006.
DOI : 10.1172/JCI28756

M. Frid, J. Brunetti, D. Burke, T. Carpenter, D. N. Reeves et al., Hypoxia-Induced Pulmonary Vascular Remodeling Requires Recruitment of Circulating Mesenchymal Precursors of a Monocyte/Macrophage Lineage, The American Journal of Pathology, vol.168, issue.2, pp.659-669, 2006.
DOI : 10.2353/ajpath.2006.050599

D. Burke, M. Frid, C. Kunrath, V. Karoor, A. Anwar et al., Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment, AJP: Lung Cellular and Molecular Physiology, vol.297, issue.2, pp.238-250, 2009.
DOI : 10.1152/ajplung.90591.2008

N. Mor-vaknin, A. Punturieri, K. Sitwala, and D. Markovitz, Vimentin is secreted by activated macrophages, Nature Cell Biology, vol.164, issue.1, pp.59-63, 2003.
DOI : 10.1074/jbc.274.22.15937

. Dorfmüller, http://respiratory-research.com/content, Respiratory Research, vol.12121, p.119119, 2011.