Cholesterol Treatment Trialists' (CTT) Collaborators: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins, Lancet, vol.366, pp.1267-1278, 2005. ,
Statins: the next step in adjuvant therapy for sepsis? Intensive Care Med, pp.11-14, 2006. ,
Statins in Endothelial Signaling and Activation, Antioxidants & Redox Signaling, vol.11, issue.4, pp.811-821, 2009. ,
DOI : 10.1089/ars.2008.2284
The effect of statins on mortality from severe infections and sepsis: A systematic review and meta-analysis, Journal of Critical Care, vol.25, issue.4, pp.656-657, 2010. ,
DOI : 10.1016/j.jcrc.2010.02.013
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, pp.1250-1256, 2001. ,
DOI : 10.1097/01.CCM.0000050454.01978.3B
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock, Critical Care Medicine, vol.32, issue.3, pp.536-555, 2004. ,
DOI : 10.1097/01.CCM.0000117317.18092.E4
Determination of atorvastatin in human serum by reversed-phase high-performance liquid chromatography with UV detection, Journal of Chromatography B, vol.826, issue.1-2, pp.41-45, 2005. ,
DOI : 10.1016/j.jchromb.2005.08.008
Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units, Critical Care Medicine, vol.26, issue.11, pp.1793-1800, 1998. ,
DOI : 10.1097/00003246-199811000-00016
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure, Intensive Care Medicine, vol.21, issue.7, pp.707-710, 1996. ,
DOI : 10.1007/BF01709751
Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples, Statistics in Medicine, vol.17, issue.1, pp.3083-3107, 2009. ,
DOI : 10.1002/sim.3697
A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use, Statistics in Medicine, vol.288, issue.12, pp.2084-2106, 2006. ,
DOI : 10.1002/sim.2328
Propensity scores in intensive care and anaesthesiology literature: a systematic review, Intensive Care Medicine, vol.24, issue.12, pp.1993-2003, 2010. ,
DOI : 10.1007/s00134-010-1991-5
Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study, The Lancet, vol.372, issue.9638, pp.562-569, 2008. ,
DOI : 10.1016/S0140-6736(08)61121-6
Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure, Statistics in Medicine, vol.4, issue.30, pp.5529-5544, 2007. ,
DOI : 10.1002/sim.3133
Statins for sepsis: a critical and updated review, Clinical Microbiology and Infection, vol.15, issue.4, pp.325-334, 2009. ,
DOI : 10.1111/j.1469-0691.2009.02750.x
Statins for infection and sepsis: a systematic review of the clinical evidence, Journal of Antimicrobial Chemotherapy, vol.61, issue.4, pp.774-785, 2008. ,
DOI : 10.1093/jac/dkn019
Statins for the Prevention and Treatment of Infections, Archives of Internal Medicine, vol.169, issue.18, pp.1658-1667, 2009. ,
DOI : 10.1001/archinternmed.2009.286
Statin therapy is associated with fewer deaths in patients with bacteraemia, Intensive Care Medicine, vol.340, issue.1, pp.75-79, 2006. ,
DOI : 10.1007/s00134-005-2859-y
Effect of Withdrawal of Pravastatin Therapy on C-Reactive Protein and Low-Density Lipoprotein Cholesterol, The American Journal of Cardiology, vol.100, issue.10, pp.1548-1551, 2007. ,
DOI : 10.1016/j.amjcard.2007.06.054
Statin Withdrawal: Clinical Implications and Molecular Mechanisms, Pharmacotherapy, vol.59, issue.3, pp.1288-1296, 2006. ,
DOI : 10.1161/01.STR.0000143319.73503.38
Rebound phenomenon of inflammatory response may be a major mechanism responsible for increased cardiovascular events after abrupt cessation of statin therapy, Medical Hypotheses, vol.66, issue.6, pp.1199-1204, 2006. ,
DOI : 10.1016/j.mehy.2005.06.035
Continuation of statin therapy in patients with presumed Figure 4 Atorvastatin plasma concentrations before and 90 minutes after receiving a 40 mg dose in nine critically ill septic patients continuing this drug while under cytochrome P450 3A4 inhibitors (in red) or not (in black) Two patients were assessed twice (circles). The residual concentrations ,
Critical CareR171 infection: a randomised controlled trial, Am J Respir Crit Care Med, vol.1515, issue.201, pp.171-774, 2011. ,
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis, Intensive Care Medicine, vol.8, issue.4, pp.717-721, 2009. ,
DOI : 10.1007/s00134-008-1358-3
Drug treatment of lipid disorders, N Engl J Med, vol.341, pp.498-511, 1999. ,
Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions, Circulation, vol.109, issue.23_suppl_1, pp.50-57, 2004. ,
DOI : 10.1161/01.CIR.0000131519.15067.1f
Statins for sepsis: a cautionary note, Intensive Care Medicine, vol.106, issue.5, p.795, 2006. ,
DOI : 10.1007/s00134-006-0143-4
Association between statin-associated myopathy and skeletal muscle damage, Canadian Medical Association Journal, vol.181, issue.1-2, pp.11-18, 2009. ,
DOI : 10.1503/cmaj.081785
Statin use and mortality within 180 days after bacteremia: A population-based cohort study*, Critical Care Medicine, vol.34, issue.4, pp.1080-1086, 2006. ,
DOI : 10.1097/01.CCM.0000207345.92928.E4
Gram-Negative Bacteremia, Archives of Internal Medicine, vol.110, issue.6, pp.847-855, 1963. ,
DOI : 10.1001/archinte.1962.03620240029006