Focus on hepatocellular carcinoma, Cancer Cell, vol.5, issue.3, pp.215-219, 2004. ,
DOI : 10.1016/S1535-6108(04)00058-3
Histopathology of liver cancers, Best Practice & Research Clinical Gastroenterology, vol.19, issue.1, pp.39-62, 2005. ,
DOI : 10.1016/j.bpg.2004.10.007
Control of Differentiation in Progression of Epithelial Tumors, Adv Cancer Res, vol.95, pp.61-113, 2006. ,
DOI : 10.1016/S0065-230X(06)95003-9
Tumor invasiveness and prognosis in resected hepatocellular carcinoma.Clinical and pathogenetic implications, Cancer, vol.54, issue.10, pp.2095-2099, 1988. ,
DOI : 10.1002/1097-0142(19880515)61:10<2095::AID-CNCR2820611027>3.0.CO;2-H
E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma, Hepatology, vol.24, issue.6, pp.1460-1467, 1996. ,
DOI : 10.1002/hep.510240627
Transcriptional repressor snail and progression of human hepatocellular carcinoma, Clin Cancer Res, vol.9, pp.2657-2664, 2003. ,
Twist Overexpression Correlates with Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition, Clinical Cancer Research, vol.12, issue.18, pp.5369-5376, 2006. ,
DOI : 10.1158/1078-0432.CCR-05-2722
Association of Vimentin overexpression and hepatocellular carcinoma metastasis, Oncogene, vol.23, pp.298-302, 2004. ,
DOI : 10.1038/sj.onc.1206483
Snail controls differentiation of hepatocytes by repressing HNF4?? expression, Journal of Cellular Physiology, vol.98, issue.1, pp.230-238, 2006. ,
DOI : 10.1002/jcp.20730
Laminin-5 With Transforming Growth Factor-??1 Induces Epithelial to Mesenchymal Transition in Hepatocellular Carcinoma, Gastroenterology, vol.129, issue.5, pp.1375-1383, 2005. ,
DOI : 10.1053/j.gastro.2005.09.055
Loss of Raf Kinase Inhibitor Protein Promotes Cell Proliferation and Migration of Human Hepatoma Cells, Gastroenterology, vol.131, issue.4, pp.1208-1217, 2006. ,
DOI : 10.1053/j.gastro.2006.07.012
Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Hepatoma Cells, Cancer Research, vol.68, issue.7, pp.2391-2399, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-2460
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression, Oncogene, vol.1775, issue.5, pp.638-650, 2009. ,
DOI : 10.1007/s00268-007-9029-z
Twist expression promotes migration and invasion in hepatocellular carcinoma, BMC Cancer, vol.14, issue.14, p.240, 2009. ,
DOI : 10.1038/sj.onc.1200998
Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells, British Journal of Cancer, vol.90, issue.6, pp.1265-1273, 2004. ,
DOI : 10.1038/sj.bjc.6601685
Hepatocyte nuclear factor 4?? controls the development of a hepatic epithelium and liver morphogenesis, Nature Genetics, vol.34, issue.3, pp.292-296, 2003. ,
DOI : 10.1038/ng1175
Hepatocyte nuclear factor 4?? orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver, Proceedings of the National Academy of Sciences, vol.103, issue.22, pp.8419-8424, 2006. ,
DOI : 10.1073/pnas.0600246103
Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors, Hepatology, vol.968, issue.4, pp.1038-1047, 2004. ,
DOI : 10.1002/hep.20155
Molecular pathogenesis of human hepatocellular carcinoma, Nature Genetics, vol.31, issue.4, pp.339-346, 2002. ,
DOI : 10.1038/ng0802-339
??-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis, The American Journal of Pathology, vol.157, issue.3, pp.763-770, 2000. ,
DOI : 10.1016/S0002-9440(10)64590-7
Mutational spectrum of ??-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas, Oncogene, vol.21, issue.31, pp.4863-4871, 2002. ,
DOI : 10.1038/sj.onc.1205591
mutations, The Journal of Pathology, vol.312, issue.3, pp.345-352, 2007. ,
DOI : 10.1002/path.2169
Expression of mutant nuclear ??-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis, The Journal of Pathology, vol.155, issue.1, pp.95-101, 2001. ,
DOI : 10.1002/1096-9896(2000)9999:9999<::AID-PATH720>3.0.CO;2-3
??-catenin mutation and overexpression in hepatocellular carcinoma, Cancer, vol.24, issue.1, pp.136-145, 2001. ,
DOI : 10.1002/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R
Genetics of hepatocellular tumors, Oncogene, vol.54, issue.27, pp.3778-3786, 2006. ,
DOI : 10.1002/hep.21068
Activation of betacatenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade, Cancer Res, vol.61, pp.2085-2091, 2001. ,
Mining the Wnt pathway for cancer therapeutics, Nature Reviews Drug Discovery, vol.55, issue.12, pp.997-1014, 2006. ,
DOI : 10.1038/nrd2154
New targets of ??-catenin signaling in the liver are involved in the glutamine metabolism, Oncogene, vol.21, issue.54, pp.8293-8301, 2002. ,
DOI : 10.1038/sj.onc.1206118
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin, Cancer Res, vol.62, pp.1971-1977, 2002. ,
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene, The EMBO Journal, vol.18, issue.21, pp.5931-5942, 1999. ,
DOI : 10.1093/emboj/18.21.5931
Expression of HNFs and C/EBPalpha is correlated with immunocytochemical differentiation of cell lines derived from human hepatocellular carcinomas, hepatoblastomas and immortalized hepatocytes, Cancer Science, vol.23, issue.9, pp.757-763, 2003. ,
DOI : 10.1111/j.1432-0436.1998.00215.x
Expression of P-aPKC-??, E-Cadherin, and ??-Catenin Related to Invasion and Metastasis in Hepatocellular Carcinoma, Annals of Surgical Oncology, vol.296, issue.5573, pp.1578-1586, 2009. ,
DOI : 10.1245/s10434-009-0423-7
Expression of HNF-1?? and HNF-1?? in various histological differentiations of hepatocellular carcinoma, The Journal of Pathology, vol.17, issue.3, pp.272-278, 1998. ,
DOI : 10.1002/(SICI)1096-9896(199803)184:3<272::AID-PATH4>3.0.CO;2-K
Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma, J Exp Clin Cancer Res, vol.26, pp.385-394, 2007. ,
WNT signalling in the immune system: WNT is spreading its wings, Nature Reviews Immunology, vol.280, issue.8, pp.581-593, 2008. ,
DOI : 10.1038/nri2360
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells, Cancer Cell, vol.6, issue.5, pp.497-506, 2004. ,
DOI : 10.1016/j.ccr.2004.09.032
Purified Wnt5a Protein Activates or Inhibits ??-Catenin???TCF Signaling Depending on Receptor Context, PLoS Biology, vol.16, issue.4, p.115, 2006. ,
DOI : 10.1371/journal.pbio.0040115.sg001
Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation, Proceedings of the National Academy of Sciences, vol.104, issue.39, pp.15436-15441, 2007. ,
DOI : 10.1073/pnas.0704747104
The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/??-Catenin Signaling, Molecular and Cellular Biology, vol.23, issue.1, pp.131-139, 2003. ,
DOI : 10.1128/MCB.23.1.131-139.2003
Activation of beta -Catenin-Tcf Signaling in Colon Cancer by Mutations in beta -Catenin or APC, Science, vol.275, issue.5307, pp.1787-1790, 1997. ,
DOI : 10.1126/science.275.5307.1787
Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells, International Journal of Cancer, vol.20, issue.6, pp.903-910, 2005. ,
DOI : 10.1002/ijc.20972
AXIN1 mutations in hepatocellular carcinomas, and growth suppression
in cancer cells by virus-mediated transfer of AXIN1, Nature Genetics, vol.16, issue.3, pp.245-250, 2000. ,
DOI : 10.1016/0042-6822(88)90302-9
p53 mutation as a source of aberrant ??-catenin accumulation in cancer cells, Oncogene, vol.21, issue.52, pp.7971-7980, 2002. ,
DOI : 10.1038/sj.onc.1205919
All Tcf HMG box transcription factors interact with Groucho-related co-repressors, Nucleic Acids Research, vol.29, issue.7, pp.1410-1419, 2001. ,
DOI : 10.1093/nar/29.7.1410
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein., Proceedings of the National Academy of Sciences, vol.92, issue.7, pp.3046-3050, 1995. ,
DOI : 10.1073/pnas.92.7.3046
The opposing roles of Wnt-5a in cancer, British Journal of Cancer, vol.8, issue.2, pp.209-214, 2009. ,
DOI : 10.1158/1078-0432.CCR-07-1644
Wnt/??-catenin signaling in hepatic organogenesis, Organogenesis, vol.283, issue.2, pp.92-99, 2008. ,
DOI : 10.1016/j.modgep.2003.11.002
Wnt/??-Catenin Signaling in Murine Hepatic Transit Amplifying Progenitor Cells, Gastroenterology, vol.133, issue.5, pp.1579-1591, 2007. ,
DOI : 10.1053/j.gastro.2007.08.036
Wnt/??-catenin signaling mediates oval cell response in rodents, Hepatology, vol.5, issue.Suppl 1, pp.288-295, 2008. ,
DOI : 10.1002/hep.21973
Wnt/??-Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells, Cancer Research, vol.68, issue.11, pp.4287-4295, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-6691
Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer, Hepatology, vol.64, issue.5, pp.1134-1143, 2002. ,
DOI : 10.1053/jhep.2002.33165
Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model, The International Journal of Biochemistry & Cell Biology, vol.43, issue.2, 2009. ,
DOI : 10.1016/j.biocel.2009.07.012
The basics of epithelial-mesenchymal transition, Journal of Clinical Investigation, vol.119, issue.6, pp.1420-1428, 2009. ,
DOI : 10.1172/JCI39104
Wnt'er in liver: Expression of Wnt and frizzled genes in mouse, Hepatology, vol.88, issue.1, pp.195-204, 2007. ,
DOI : 10.1002/hep.21473
Oncogenic role of the frizzled-7/??-catenin pathway in hepatocellular carcinoma, Journal of Hepatology, vol.43, issue.5, pp.854-862, 2005. ,
DOI : 10.1016/j.jhep.2005.05.018
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/??-catenin signaling pathway in hepatocellular carcinoma cells, Journal of Hepatology, vol.48, issue.5, pp.780-791, 2008. ,
DOI : 10.1016/j.jhep.2007.12.020
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma, British Journal of Cancer, vol.20, issue.1, pp.143-150, 2008. ,
DOI : 10.1016/j.humpath.2006.06.023
WNT10B Functional Dualism: beta-Catenin/Tcf-dependent Growth Promotion or Independent Suppression with Deregulated Expression in Cancer, Molecular Biology of the Cell, vol.18, issue.11, pp.4292-4303, 2007. ,
DOI : 10.1091/mbc.E06-10-0889
Expression of Wnt-5a and its clinicopathological significance in hepatocellular carcinoma, Digestive and Liver Disease, vol.40, issue.7, pp.560-567, 2008. ,
DOI : 10.1016/j.dld.2007.12.011
Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses, Carcinogenesis, vol.29, issue.6, pp.1207-1214, 2008. ,
DOI : 10.1093/carcin/bgn111
Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo, Int J Cancer, 2009. ,
Wnt signalling in stem cells and cancer, Nature, vol.167, issue.7035, pp.843-850, 2005. ,
DOI : 10.1016/S1534-5807(04)00105-4
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties, Hepatology, vol.24, issue.1, pp.240-251, 2006. ,
DOI : 10.1002/hep.21227
Loss of TGF-?? or Wnt5a results in an increase in Wnt/??-catenin activity and redirects mammary tumour phenotype, Breast Cancer Research, vol.168, issue.2, p.19, 2009. ,
DOI : 10.1006/dbio.1995.1060
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3???independent ??-catenin degradation, The Journal of Cell Biology, vol.125, issue.5, pp.899-908, 2003. ,
DOI : 10.1016/S1097-2765(00)80200-2
Transformation by Wnt family proteins correlates with regulation of beta-catenin, Cell Growth Differ, vol.8, pp.1349-1358, 1997. ,
Downregulation of Wnt4 and upregulation of Wnt5a expression by epithelialmesenchymal transition in human squamous carcinoma cells, Cancer Science, vol.8, issue.7, pp.593-597, 2003. ,
DOI : 10.1038/35020115
The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition, Journal of Biological Chemistry, vol.282, issue.23, pp.17259-17271, 2007. ,
DOI : 10.1074/jbc.M700075200
WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer, Carcinogenesis, vol.28, issue.6, pp.5-1178, 2007. ,
DOI : 10.1093/carcin/bgl255
EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features, Gastroenterology, vol.136, issue.3, pp.1012-1024, 2009. ,
DOI : 10.1053/j.gastro.2008.12.004
Apc Tumor Suppressor Gene Is the ???Zonation-Keeper??? of Mouse Liver, Developmental Cell, vol.10, issue.6, pp.759-770, 2006. ,
DOI : 10.1016/j.devcel.2006.03.015
Liver Zonation Occurs Through a ??-Catenin???Dependent, c-Myc???Independent Mechanism, Gastroenterology, vol.136, issue.7, pp.2316-2324, 2009. ,
DOI : 10.1053/j.gastro.2009.02.063
Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model, Proceedings of the National Academy of Sciences, vol.106, issue.4, pp.1193-1198, 2009. ,
DOI : 10.1073/pnas.0811902106