Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].

Abstract : Klinefelter syndrome is defined by the presence of a supernumerary X chromosome in a phenotypic male. It is the most frequent gonosomic anomaly in infertile men with an incidence of 0.1 to 0.2% in newborn males. The presence of an additional X chromosome induces spermatogenic failure but when gametes are present, they are usually normal. The risk of transmission of the chromosomal anomaly remains low. In the literature, only one 47,XXY foetus resulting from more than a hundred births from fathers with Klinefelter syndrome, has been reported. One can estimate, that a TESE performed in half of the patients with non-mosaic 47,XXY will be positive and may enable IVF/ICSI to be achieved.
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Article dans une revue
Gynécologie Obstétrique et Fertilité, Elsevier Masson, 2011, 39 (9), pp.525-8. 〈10.1016/j.gyobfe.2011.07.003〉
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http://www.hal.inserm.fr/inserm-00620761
Contributeur : Hervé De Villemeur <>
Soumis le : jeudi 8 septembre 2011 - 15:34:01
Dernière modification le : mercredi 21 février 2018 - 01:31:40

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Célia Ravel, Sandra Chantot-Bastaraud, J. Cretet, Patricia Roynard, Mathilde Sibony, et al.. Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].. Gynécologie Obstétrique et Fertilité, Elsevier Masson, 2011, 39 (9), pp.525-8. 〈10.1016/j.gyobfe.2011.07.003〉. 〈inserm-00620761〉

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