T. Wong and S. Lee, Hepatitis C: a review for primary care physicians, Canadian Medical Association Journal, vol.174, issue.5, pp.649-659, 2006.
DOI : 10.1503/cmaj.1030034

J. Pawlotsky and J. Mchutchison, Hepatitis C. Development of new drugs and clinical trials: Promises and pitfalls. Summary of an AASLD hepatitis single topic conference, Chicago, IL, February 27-March 1, 2003, Hepatology, vol.34, issue.2, pp.554-567, 2004.
DOI : 10.1002/hep.20065
URL : https://hal.archives-ouvertes.fr/inserm-00777736

D. Strader, T. Wright, D. Thomas, and L. Seeff, Diagnosis, management, and treatment of hepatitis C, Hepatology, vol.24, issue.suppl, pp.1147-1171, 2004.
DOI : 10.1002/hep.20119

N. Dixit, J. Layden-almer, T. Layden, and A. Perelson, Modelling how ribavirin improves interferon response rates in hepatitis C virus infection, Nature, vol.23, issue.7019, pp.922-924, 2004.
DOI : 10.1086/315661

J. Feld and J. Hoofnagle, Mechanism of action of interferon and ribavirin in treatment of hepatitis C, Nature, vol.128, issue.7053, pp.967-972, 2005.
DOI : 10.1126/science.1114016

N. Zein, Clinical Significance of Hepatitis C Virus Genotypes, Clinical Microbiology Reviews, vol.13, issue.2, pp.223-225, 2000.
DOI : 10.1128/CMR.13.2.223-235.2000

S. Carroll and D. Olsen, Nucleoside Analog Inhibitors of Hepatitis C Virus Replication, Infectious Disorders - Drug Targets, vol.6, issue.1, pp.17-29, 2006.
DOI : 10.2174/187152606776056698

P. Beaulieu, Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection, Expert Opinion on Therapeutic Patents, vol.46, issue.2, pp.145-164, 2009.
DOI : 10.1016/j.jhep.2005.12.006

F. Pauwels, W. Mostmans, L. Quirynen, L. Van-der-helm, C. Boutton et al., Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors, Journal of Virology, vol.81, issue.13, pp.6909-6919, 2007.
DOI : 10.1128/JVI.01543-06

S. Harper, B. Pacini, S. Avolio, D. Filippo, M. Migliaccio et al., -Acetamide Inhibitors of Hepatitis C Virus NS5B Polymerase, Journal of Medicinal Chemistry, vol.48, issue.5, pp.1314-1317, 2005.
DOI : 10.1021/jm049122i
URL : https://hal.archives-ouvertes.fr/hal-01060399

I. Stansfield, C. Ercolani, A. Mackay, I. Conte, M. Pompei et al., Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase, Bioorganic & Medicinal Chemistry Letters, vol.19, issue.3, pp.627-632, 2009.
DOI : 10.1016/j.bmcl.2008.12.068

J. Habermann, E. Capito, R. R. Ferreira, M. Koch, U. Narjes et al., Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase, Bioorganic & Medicinal Chemistry Letters, vol.19, issue.3, pp.633-638, 2009.
DOI : 10.1016/j.bmcl.2008.12.039

S. Goulet, M. Poupart, J. Gillard, M. Poirier, G. Kukolj et al., Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.1, pp.196-200, 2010.
DOI : 10.1016/j.bmcl.2009.10.136

P. Beaulieu, E. Jolicoeur, J. Gillard, C. Brochu, R. Coulombe et al., N-Acetamideindolecarboxylic acid allosteric ???finger-loop??? inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.3, pp.857-861, 2010.
DOI : 10.1016/j.bmcl.2009.12.101

P. Beaulieu, N. Dansereau, J. Duan, M. Garneau, J. Gillard et al., Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.6, pp.1825-1829, 2010.
DOI : 10.1016/j.bmcl.2010.02.003

A. Boumendjel, [General Articles] Aurones: A Subclass of Flavones with Promising Biological Potential, Current Medicinal Chemistry, vol.10, issue.23, pp.2621-2630, 2003.
DOI : 10.2174/0929867033456468

M. Seikel and T. Geissman, Anthochlor Pigments. VII. The Pigments of Yellow Antirrhinum Majus, Journal of the American Chemical Society, vol.72, issue.12, pp.5725-5730, 1950.
DOI : 10.1021/ja01168a095

T. Nakayama, K. Yonekura-sakakibara, T. Sato, S. Kikuchi, Y. Fukui et al., Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration, Science, vol.290, issue.5494, pp.1163-1166, 2000.
DOI : 10.1126/science.290.5494.1163

S. Varma and M. Varma, Alumina-mediated condensation. A simple synthesis of aurones, Tetrahedron Letters, vol.33, issue.40, pp.5937-5940, 1992.
DOI : 10.1016/S0040-4039(00)61093-6

C. Beney, A. Mariotte, A. G. Boumendjel, and M. Weinreb, An efficient synthesis of 4,6-dimethoxy aurones Total syntheses of aflatoxins M and G and an improved synthesis of aflatoxin, Heterocycles, vol.55, issue.23 1, pp.967-972, 2001.

S. Okombi, D. Rival, S. Bonnet, A. Mariotte, E. Perrier et al., )-one (Aurones) as Inhibitors of Tyrosinase Derived from Human Melanocytes, Journal of Medicinal Chemistry, vol.49, issue.1, pp.329-333, 2006.
DOI : 10.1021/jm050715i

C. Brehm, P. Zimmermann, S. Zemolka, A. Palmer, W. Buhr et al., Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives . International Patent Application WO, p.17, 2008.

J. Kodra, P. Madsen, J. Lau, A. Jorgensen, and I. Christensen, Novel glucagon antagonists . International Patent Application WO, p.12, 2003.

A. Ahmed-belkacem, N. Ahnou, L. Barbotte, C. Wychowski, C. Pallier et al., Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase, Gastroenterology, vol.138, issue.3, pp.1112-1122, 2010.
DOI : 10.1053/j.gastro.2009.11.053
URL : https://hal.archives-ouvertes.fr/inserm-00465965