PMID: identifiant
de la référence Pubmed : |
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 (19640273)  |
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| titre : |
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Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). |
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| auteur(s) : |
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Federico Canzian ( ) 1, Rudolf Kaaks1, David Cox2, Katherine Henderson3, 4, Brian Henderson3, Christine Berg5, Sheila Bingham6, Heiner Boeing7, Julie Buring8, Eugenia Calle9, Stephen Chanock5, Françoise Clavel-Chapelon10, Laure Dossus1, Heather Feigelson9, Christopher Haiman3, Susan Hankinson8, Robert Hoover5, David Hunter2, Claudine Isaacs11, Per Lenner12, Eiliv Lund13, Kim Overvad14, Domenico Palli15, Celeste Pearce3, Jose Quiros16, Elio Riboli17, Daniel Stram3, Gilles Thomas5, Michael Thun9, Dimitrios Trichopoulos18, Carla van Gils19, Regina Ziegler5 |
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| laboratoire : |
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| 1 : |
DKFZ - German Cancer Research Center |
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| DKFZ |
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| Heidelberg |
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| Allemagne |
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| 2 : |
Harvard School of Public Health |
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| Harvard School of Public Health |
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| Boston, MA |
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| États-Unis |
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| 3 : |
University of Southern California |
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| University of California, Los Angeles |
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| Los Angeles, CA |
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| États-Unis |
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| 4 : |
Beckman Research Institute |
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| City of Hope National Medical Center |
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| Duarte, CA |
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| États-Unis |
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| 5 : |
Division of Cancer Epidemiology and Genetics |
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| National Cancer Institute |
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| Bethesda, MD |
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| États-Unis |
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| 6 : |
Dunn Human Nutrition Unit |
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| MRC |
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| Cambridge |
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| Royaume-Uni |
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| 7 : |
Department of Epidemiology |
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| German Institute of Human Nutrition Potsdam-Rehbruecke |
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| Potsdam-Rehbruecke, Nuthetal |
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| Allemagne |
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| 8 : |
HMS - Harvard Medical School |
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| http://www.hms.harvard.edu |
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| Harvard University |
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| 25 Shattuck Street Boston, MA 02115 |
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| États-Unis |
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| 9 : |
American Cancer Society |
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| American Cancer Society |
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| Atlanta, GA |
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| États-Unis |
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| 10 : |
E3N - Nutrition, hormones et cancer: épidémiologie et prévention |
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| http://www.idf.inserm.fr/site/eri20/ |
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| INSERM : ERI20 – IFR69 – Université Paris XI - Paris Sud : EA4045 |
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| Institut Gustave-Roussy 39 rue Camille Desmoulins 94805 Villejuif CEDEX |
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| France |
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| 11 : |
Lombardi Comprehensive Cancer Center |
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| Georgetown University |
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| Washington DC |
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| États-Unis |
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| 12 : |
Department of Radiation Sciences, Oncology |
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| Umea University |
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| Umeå |
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| Suède |
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| 13 : |
Institute of Community Medicine |
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| University of Tromsø |
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| Norvège |
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| 14 : |
Department of Clinical Epidemiology |
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| Aarhus University Hospital |
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| Danemark |
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| 15 : |
Molecular and Nutritional Epidemiology Unit |
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| CSPO-Scientific Institute of Tuscany |
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| Florence |
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| Italie |
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| 16 : |
Public Health and Health Planning Directorate |
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| Public Health and Health Planning Directorate |
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| Asturias |
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| Espagne |
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| 17 : |
Imperial College |
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| Imperial College |
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| London |
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| Royaume-Uni |
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| 18 : |
Department of Hygiene and Epidemiology |
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| University of Athens |
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| Grèce |
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| 19 : |
Julius Center for Health Sciences and Primary Care |
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| Utrecht university medical center |
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| Pays-Bas |
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| résumé : |
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BACKGROUND: Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones. We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3). METHODS: We sequenced exons of GNRH1 and GNRHR in 95 invasive breast cancer cases. Resulting single nucleotide polymorphisms (SNPs) were genotyped and used to identify haplotype-tagging SNPs (htSNPS) in a panel of 349 healthy women. The htSNPs were genotyped in 5,603 invasive breast cancer cases and 7,480 controls from the Cancer Prevention Study-II (CPS-II), European Prospective Investigation on Cancer and Nutrition (EPIC), Multiethnic Cohort (MEC), Nurses' Health Study (NHS), and Women's Health Study (WHS). Circulating levels of sex steroids (androstenedione, estradiol, estrone and testosterone) were also measured in 4713 study subjects. RESULTS: Breast cancer risk was not associated with any polymorphism or haplotype in the GNRH1 and GNRHR genes, nor were there any statistically significant interactions with known breast cancer risk factors. Polymorphisms in these two genes were not strongly associated with circulating hormone levels. CONCLUSION: Common variants of the GNRH1 and GNRHR genes are not associated with risk of invasive breast cancer in Caucasians. |
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| domaine : |
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Sciences du Vivant/Cancérologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1471-2407 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1186/1471-2407-9-257 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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2009 |
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date de publication
électronique : |
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29/07/2009 |
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| volume : |
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9 |
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| numéro : |
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1 |
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| page, identifiant, ... : |
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257 |
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| Descripteur(s) MeSH : |
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Breast Neoplasms – Cohort Studies – European Continental Ancestry Group – Exons – Female – Genetic Variation – Genotype – Gonadotropin-Releasing Hormone – Haplotypes – Humans – Neoplasm Invasiveness – Polymorphism – Genetic – Single Nucleotide – Prospective Studies – Protein Precursors – Receptors – LHRH |
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| contrat, financement : |
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This work was funded by NCI grants U01 CA098216 (EPIC), U01CA098233 (Harvard), U01CA098758 (MEC) and U01 CA098710 (ACS) |
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