Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese.

Abstract : Carotid-femoral pulse wave velocity (PWV) is considered the gold-standard measurement of arterial stiffness. Obesity, however, can render inaccurate the measurement of PWV by external noninvasive devices. Phase-contrast MRI allows the determination of aortic PWV in multiple aortic locations with intra-arterial distance measurements, as well as the assessment of aortic mechanical properties. The purpose of this study was to assess the reliability of external carotid-femoral PWV values measured by well-validated external devices in comparison with MRI acquisitions of PWV and aortic mechanical properties in a population of obese subjects. PWV was measured with PulsePen and Complior II devices in 32 volunteers (18 men and 14 women), aged 46 to 65 years (mean: 55.7+/-5.1 years), presenting with isolated abdominal obesity, with a waist circumference >102 cm for men and >88 cm for women, and a body mass index between 27 and 35. These results were then compared with MRI PWV values and cross-sectional MRI thoracic aorta distensibility values. MRI PWV values were positively correlated with PWV measured by both PulsePen (r=0.47; P=0.005) and Complior (r=0.43; P=0.01). Aortic cross-sectional stiffness was positively correlated with PulsePen PWV (r=0.42; P=0.02). The same trend was also observed with Complior PWV (r=0.33; P=0.06). This is the first study comparing transcutaneous PWV measurements with MRI aortic elastic properties in obese subjects. Our results indicate that, for body mass index values < or =35 kg m(-2), PWV measured externally with Complior or PulsePen validly reflect values obtained directly in the thoracic aorta through MRI.
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Hypertension, American Heart Association, 2009, 54 (2), pp.421-6. 〈10.1161/HYPERTENSIONAHA.109.133645〉
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Soumis le : vendredi 26 août 2011 - 10:15:41
Dernière modification le : vendredi 9 février 2018 - 17:10:02

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Laure Joly, Christine Perret-Guillaume, Anna Kearney-Schwartz, Paolo Salvi, Damien Mandry, et al.. Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese.. Hypertension, American Heart Association, 2009, 54 (2), pp.421-6. 〈10.1161/HYPERTENSIONAHA.109.133645〉. 〈inserm-00617102〉

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