J. Pickup and M. Crook, Is Type II diabetes mellitus a disease of the innate immune system?, Diabetologia, vol.41, issue.10, pp.1241-1248, 1998.
DOI : 10.1007/s001250051058

G. Hotamisligil, Inflammation and metabolic disorders, Nature, vol.314, issue.7121, pp.860-867, 2006.
DOI : 10.1038/nature05485

S. Weisberg, D. Mccann, M. Desai, M. Rosenbaum, and R. Leibel, Obesity is associated with macrophage accumulation in adipose tissue, Journal of Clinical Investigation, vol.112, issue.12, pp.1796-1808, 2003.
DOI : 10.1172/JCI19246DS1

P. Cani, J. Amar, M. Iglesias, M. Poggi, and C. Knauf, Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, Diabetes, vol.56, issue.7, pp.1761-1772, 2007.
DOI : 10.2337/db06-1491

P. Cani, R. Bibiloni, C. Knauf, A. Waget, and A. Neyrinck, Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice, Diabetes, vol.57, issue.6, pp.1470-1481, 2008.
DOI : 10.2337/db07-1403

URL : https://hal.archives-ouvertes.fr/inserm-00410066

N. Yasuda, T. Inoue, T. Nagakura, K. Yamazaki, and K. Kira, Enhanced secretion of glucagon-like peptide 1 by biguanide compounds, Biochemical and Biophysical Research Communications, vol.298, issue.5, pp.779-784, 2002.
DOI : 10.1016/S0006-291X(02)02565-2

A. Maida, B. Lamont, X. Cao, and D. Drucker, Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-?? in mice, Diabetologia, vol.59, issue.Suppl 1, pp.339-349, 2010.
DOI : 10.1007/s00125-010-1937-z

P. Brubaker, Regulation of Intestinal Proglucagon- Derived Peptide Secretion by Intestinal Regulatory Peptides*, Endocrinology, vol.128, issue.6, pp.3175-3182, 1991.
DOI : 10.1210/endo-128-6-3175

F. Gribble, L. Williams, A. Simpson, and F. Reimann, A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line, Diabetes, vol.52, issue.5, pp.1147-1154, 2003.
DOI : 10.2337/diabetes.52.5.1147

K. Harikumar and B. Aggarwal, Resveratrol: A multitargeted agent for age-associated chronic diseases, Cell Cycle, vol.7, issue.8, pp.1020-1035, 2008.
DOI : 10.4161/cc.7.8.5740

M. Lagouge, C. Argmann, Z. Gerhart-hines, H. Meziane, and C. Lerin, Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1??, Cell, vol.127, issue.6, pp.1109-1122, 2006.
DOI : 10.1016/j.cell.2006.11.013

URL : https://hal.archives-ouvertes.fr/hal-00188005

J. Milne, P. Lambert, S. Schenk, D. Carney, and J. Smith, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, vol.104, issue.7170, pp.712-716, 2007.
DOI : 10.1038/nature06261

X. Gao, Y. Xu, N. Janakiraman, R. Chapman, and S. Gautam, Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation , development of cell-mediated cytotoxicity, and cytokine production, BiochemPharmacol, vol.62, pp.1299-1308, 2001.

S. Manna, A. Mukhopadhyay, and B. Aggarwal, Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-??B, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation, The Journal of Immunology, vol.164, issue.12, pp.6509-6519, 2000.
DOI : 10.4049/jimmunol.164.12.6509

C. Argmann and J. Auwerx, Insulin Secretion: SIRT4 Gets in on the Act, Cell, vol.126, issue.5, pp.837-839, 2006.
DOI : 10.1016/j.cell.2006.08.031

URL : https://hal.archives-ouvertes.fr/hal-00187838

N. Ahuja, B. Schwer, S. Carobbio, D. Waltregny, and B. North, Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase, Journal of Biological Chemistry, vol.282, issue.46, pp.33583-33592, 2007.
DOI : 10.1074/jbc.M705488200

J. Rodgers, C. Lerin, W. Haas, S. Gygi, and B. Spiegelman, Nutrient control of glucose homeostasis through a complex of PGC-1?? and SIRT1, Nature, vol.103, issue.7029, pp.113-118, 2005.
DOI : 10.1101/gad.1164804

V. Nayagam, X. Wang, Y. Tan, A. Poulsen, and K. Goh, SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents, Journal of Biomolecular Screening, vol.280, issue.8, pp.959-967, 2006.
DOI : 10.1177/1087057106294710

T. Shi, F. Wang, E. Stieren, and Q. Tong, SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes, Journal of Biological Chemistry, vol.280, issue.14, pp.13560-13567, 2005.
DOI : 10.1074/jbc.M414670200

Z. Gerhart-hines, J. Rodgers, O. Bare, C. Lerin, and S. Kim, Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1??, The EMBO Journal, vol.98, issue.7, pp.1913-1923, 2007.
DOI : 10.1038/sj.emboj.7601633

J. Baur, K. Pearson, N. Price, H. Jamieson, and C. Lerin, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, vol.35, issue.7117, pp.337-342, 2006.
DOI : 10.1038/nature05354

D. Beher, J. Wu, S. Cumine, K. Kim, and S. Lu, Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity, Chemical Biology & Drug Design, vol.8, issue.6, pp.619-624, 2009.
DOI : 10.1111/j.1747-0285.2009.00901.x

A. Khalil, P. Villard, M. Dao, R. Burcelin, and S. Champion, Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation, Toxicology Letters, vol.196, issue.3, pp.161-167, 2010.
DOI : 10.1016/j.toxlet.2010.04.010

URL : https://hal.archives-ouvertes.fr/inserm-00492275

R. Casper, M. Quesne, I. Rogers, T. Shirota, and A. Jolivet, Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity, Mol Pharmacol, vol.56, pp.784-790, 1999.

C. Knauf, P. Cani, A. Ait-belgnaoui, A. Benani, and C. Dray, Brain Glucagon-Like Peptide 1 Signaling Controls the Onset of High-Fat Diet-Induced Insulin Resistance and Reduces Energy Expenditure, Endocrinology, vol.149, issue.10, pp.4768-4777, 2008.
DOI : 10.1210/en.2008-0180

URL : https://hal.archives-ouvertes.fr/inserm-00409099

P. Cani, A. Neyrinck, F. Fava, C. Knauf, and R. Burcelin, Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia, Diabetologia, vol.77, issue.Suppl 1, pp.2374-2383, 2007.
DOI : 10.1007/s00125-007-0791-0

E. Riant, A. Waget, H. Cogo, J. Arnal, and R. Burcelin, Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.3, pp.2109-2117, 2009.
DOI : 10.1210/jcem.94.3.9995

URL : https://hal.archives-ouvertes.fr/inserm-00410271

G. Caraux and S. Pinloche, PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order, Bioinformatics, vol.21, issue.7, pp.1280-1281, 2005.
DOI : 10.1093/bioinformatics/bti141

URL : https://hal.archives-ouvertes.fr/lirmm-00105307

P. Langcake and R. Pryce, A new class of phytoalexins from grapevines, Experientia, vol.260, issue.2, pp.151-152, 1977.
DOI : 10.1007/BF02124034

W. Wang, H. Lai, P. Hsueh, R. Chiou, and S. Lin, Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol, Journal of Medical Microbiology, vol.55, issue.10, pp.1313-1321, 2006.
DOI : 10.1099/jmm.0.46661-0

M. Chan, Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin, Biochemical Pharmacology, vol.63, issue.2, pp.99-104, 2002.
DOI : 10.1016/S0006-2952(01)00886-3

D. Drucker, Biological actions and therapeutic potential of the glucagon-like peptides, Gastroenterology, vol.122, issue.2, pp.531-544, 2002.
DOI : 10.1053/gast.2002.31068

M. Nauck, Therapeutic potential of glucagon-like peptide 1 in type 2 diabetes, Diabet Med, vol.13, pp.39-43, 1996.

R. Burcelin, The incretins: a link between nutrients and well-being, British Journal of Nutrition, vol.128, issue.S1, 2005.
DOI : 10.1055/s-0029-1211391

P. Cani, J. Holst, D. Drucker, N. Delzenne, and B. Thorens, GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion, Molecular and Cellular Endocrinology, vol.276, issue.1-2, 2007.
DOI : 10.1016/j.mce.2007.06.003

URL : https://hal.archives-ouvertes.fr/hal-00531937

B. Ahrén, Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes, Expert Opinion on Emerging Drugs, vol.50, issue.4, pp.593-607, 2008.
DOI : 10.1152/ajpcell.00173.2008

A. Dal-pan, S. Blanc, and F. Aujard, Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity, BMC Physiology, vol.10, issue.1, p.11, 2010.
DOI : 10.1186/1472-6793-10-11

URL : https://hal.archives-ouvertes.fr/hal-00518023

X. Vitrac, A. Desmoulière, B. Brouillaud, S. Krisa, and G. Deffieux, Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration, Life Sciences, vol.72, issue.20, pp.2219-2233, 2003.
DOI : 10.1016/S0024-3205(03)00096-1

D. Kennedy, E. Wightman, J. Reay, G. Lietz, and E. Okello, Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation, American Journal of Clinical Nutrition, vol.91, issue.6, 2010.
DOI : 10.3945/ajcn.2009.28641

P. Cani, C. Knauf, M. Iglesias, D. Drucker, and N. Delzenne, Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor, Diabetes, vol.55, issue.5, pp.1484-1490, 2006.
DOI : 10.2337/db05-1360

H. Putaala, T. Salusjä-rvi, M. Nordström, M. Saarinen, and A. Ouwehand, Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression, Research in Microbiology, vol.159, issue.9-10, pp.692-698, 2008.
DOI : 10.1016/j.resmic.2008.08.002

P. Turnbaugh, V. Ridaura, J. Faith, F. Rey, and R. Knight, The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice, Science Translational Medicine, vol.1, issue.6, pp.6-14, 2009.
DOI : 10.1126/scitranslmed.3000322