G. Kruh, Introduction to resistance to anticancer agents, Oncogene, pp.7262-7264, 2003.
DOI : 10.1038/sj.onc.1206932

M. Gottesman, T. Fojo, and S. Bates, MULTIDRUG RESISTANCE IN CANCER: ROLE OF ATP-DEPENDENT TRANSPORTERS, Nature Reviews Cancer, vol.2, issue.1, pp.48-58, 2002.
DOI : 10.1038/nrc706

C. Xu, C. Li, and A. Kong, Induction of phase I, II and III drug metabolism/transport by xenobiotics, Archives of Pharmacal Research, vol.182, issue.481, pp.249-268, 2005.
DOI : 10.1007/BF02977789

N. Plant, The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.478-488
DOI : 10.1016/j.bbagen.2006.09.024

C. Scripture, A. Sparreboom, and W. Figg, Modulation of cytochrome P450 activity: implications for cancer therapy, The Lancet Oncology, vol.6, issue.10, pp.780-789, 2005.
DOI : 10.1016/S1470-2045(05)70388-0

B. Blumberg, W. Sabbagh, . Jr, H. Juguilon, J. Bolado et al., SXR, a novel steroid and xenobioticsensing nuclear receptor, Genes & Development, vol.12, issue.20, pp.3195-3205, 1998.
DOI : 10.1101/gad.12.20.3195

B. Goodwin, E. Hodgson, and C. Liddle, The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module, Mol Pharmacol, vol.56, pp.1329-1339, 1999.

S. Kliewer, J. Moore, L. Wade, J. Staudinger, M. Watson et al., An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway, Cell, vol.92, issue.1, pp.73-82, 1998.
DOI : 10.1016/S0092-8674(00)80900-9

J. Lehmann, D. Mckee, M. Watson, T. Willson, J. Moore et al., The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions., Journal of Clinical Investigation, vol.102, issue.5, pp.1016-1023, 1998.
DOI : 10.1172/JCI3703

G. Lemaire, G. De-sousa, and R. Rahmani, A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides, Biochemical Pharmacology, vol.68, issue.12, pp.2347-2358, 2004.
DOI : 10.1016/j.bcp.2004.07.041

Y. Chen, S. Ferguson, M. Negishi, and J. Goldstein, Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter, Molecular Pharmacology, vol.64, issue.2, pp.316-324
DOI : 10.1124/mol.64.2.316

Y. Chen, S. Ferguson, M. Negishi, and J. Goldstein, Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor, Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.2, pp.495-501
DOI : 10.1124/jpet.103.058818

S. Ferguson, Y. Chen, E. Lecluyse, M. Negishi, and J. Goldstein, Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive Basseville et al. Molecular Cancer http://www.molecular-cancer.com/content/10/1/80 androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4 alpha United States, In Mol Pharmacol, vol.10, issue.2005, pp.80747-757, 2011.

S. Gerbal-chaloin, J. Pascussi, L. Pichard-garcia, M. Daujat, F. Waechter et al., Induction of CYP2C genes in human hepatocytes in primary culture, Drug Metab Dispos, vol.29, pp.242-251, 2001.

B. Goodwin, L. Moore, C. Stoltz, D. Mckee, and S. Kliewer, Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor, Mol Pharmacol, vol.60, pp.427-431, 2001.

W. Xie, M. Yeuh, A. Radominska-pandya, S. Saini, Y. Negishi et al., Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor United States, Proc Natl Acad Sci, pp.4150-4155

C. Frank, H. Makkonen, T. Dunlop, M. Matilainen, S. Vaisanen et al., Identification of Pregnane X Receptor Binding Sites in the Regulatory Regions of Genes Involved in Bile Acid Homeostasis, Journal of Molecular Biology, vol.346, issue.2, pp.505-519, 2005.
DOI : 10.1016/j.jmb.2004.12.003

A. Geick, M. Eichelbaum, and O. Burk, Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin, Journal of Biological Chemistry, vol.276, issue.18, pp.14581-14587
DOI : 10.1074/jbc.M010173200

S. Aggarwal and E. Chu, Current therapies for advanced colorectal cancer, Oncology, vol.19, pp.589-595, 2005.

R. Humerickhouse, K. Lohrbach, L. Li, W. Bosron, and M. Dolan, Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2, Cancer Res, vol.60, pp.1189-1192, 2000.

Y. Pommier, Topoisomerase I inhibitors: camptothecins and beyond, Nature Reviews Cancer, vol.24, issue.10, pp.789-802, 2006.
DOI : 10.1038/nrc1977

A. Santos, S. Zanetta, T. Cresteil, A. Deroussent, F. Pein et al., Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans, Clin Cancer Res, vol.6, pp.2012-2020, 2000.

J. Gagne, V. Montminy, P. Belanger, K. Journault, G. Gaucher et al., Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38), Molecular Pharmacology, vol.62, issue.3
DOI : 10.1124/mol.62.3.608

Z. Chen, T. Furukawa, T. Sumizawa, K. Ono, K. Ueda et al., ATP- Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P, Mol Pharmacol, vol.55, pp.921-928, 1999.

X. Chu, Y. Kato, and Y. Sugiyama, Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats, Cancer Res, vol.57, pp.1934-1938, 1997.

L. Iyer, J. Ramirez, D. Shepard, C. Bingham, D. Hossfeld et al., Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice, Cancer Chemotherapy and Pharmacology, vol.49, issue.4, pp.336-341, 2002.
DOI : 10.1007/s00280-001-0420-4

S. Kawabata, M. Oka, K. Shiozawa, K. Tsukamoto, K. Nakatomi et al., Breast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells, Biochemical and Biophysical Research Communications, vol.280, issue.5, pp.1216-1223
DOI : 10.1006/bbrc.2001.4267

K. Nakatomi, M. Yoshikawa, M. Oka, Y. Ikegami, S. Hayasaka et al., Transport of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Breast Cancer Resistance Protein ABCG2 in Human Lung Cancer Cells, Biochemical and Biophysical Research Communications, vol.288, issue.4, pp.827-832
DOI : 10.1006/bbrc.2001.5850

D. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schutz et al., The nuclear receptor superfamily: The second decade, Cell, vol.83, issue.6, pp.835-839
DOI : 10.1016/0092-8674(95)90199-X

W. Xie, J. Barwick, C. Simon, A. Pierce, S. Safe et al., Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR, Genes & Development, vol.14, issue.23, pp.3014-3023, 2000.
DOI : 10.1101/gad.846800

C. Zhou, S. Verma, and B. Blumberg, The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism, Nuclear Receptor Signaling, vol.4, p.1, 2009.
DOI : 10.1621/nrs.07001

H. Masuyama, N. Suwaki, Y. Tateishi, H. Nakatsukasa, T. Segawa et al., The Pregnane X Receptor Regulates Gene Expression in a Ligand- and Promoter- Selective Fashion, Molecular Endocrinology, vol.19, issue.5, pp.1170-1180
DOI : 10.1210/me.2004-0434

C. Zhou, M. Tabb, A. Sadatrafiei, F. Grun, and B. Blumberg, TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES, Drug Metabolism and Disposition, vol.32, issue.10, pp.1075-1082
DOI : 10.1124/dmd.104.000299

R. Watkins, G. Wisely, L. Moore, J. Collins, M. Lambert et al., The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity, Science, vol.292, issue.5525, pp.2329-2333
DOI : 10.1126/science.1060762

T. Synold, I. Dussault, and B. Forman, The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux, In Nat Med. United States, vol.7, issue.2001, pp.584-590

G. Xu, W. Zhang, M. Ma, and H. Mcleod, Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan, Clin Cancer Res, vol.8, pp.2605-2611, 2002.

J. Zhou, M. Liu, Y. Zhai, and W. Xie, The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells, Molecular Endocrinology, vol.22, issue.4, pp.868-880
DOI : 10.1210/me.2007-0197

N. Zucchini, G. De-sousa, B. Bailly-maitre, J. Gugenheim, R. Bars et al., Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1745, issue.1, pp.48-58
DOI : 10.1016/j.bbamcr.2005.02.005

S. Verma, M. Tabb, and B. Blumberg, Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells, BMC Cancer, vol.71, issue.1, p.3, 2009.
DOI : 10.1124/mol.106.029264

H. Gong, S. Singh, S. Singh, Y. Mu, J. Lee et al., Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells, Molecular Endocrinology, vol.20, issue.2, pp.279-290
DOI : 10.1210/me.2005-0205
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.5115

P. Desai, S. Nallani, R. Sane, L. Moore, B. Goodwin et al., Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen, Drug Metabolism and Disposition, vol.30, issue.5, pp.608-612, 2002.
DOI : 10.1124/dmd.30.5.608

E. Mensah-osman, D. Thomas, M. Tabb, J. Larios, D. Hughes et al., Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines, Cancer, vol.278, issue.5, pp.957-965, 2007.
DOI : 10.1002/cncr.22479

N. Takami, H. Sakamoto, and T. Yamamoto, Steroid and Xenobiotic Receptor (SXR) is a Key System for the Acquisition of Cisplatin Resistance in Endometrial Cancer Cells, Journal of International Medical Research, vol.11, issue.2, pp.59-68, 2003.
DOI : 10.1177/147323000303100201

H. Masuyama, H. Nakatsukasa, N. Takamoto, and Y. Hiramatsu, Down-Regulation of Pregnane X Receptor Contributes to Cell Growth Inhibition and Apoptosis by Anticancer Agents in Endometrial Cancer Cells, Molecular Pharmacology, vol.72, issue.4, pp.1045-1053
DOI : 10.1124/mol.107.037937

Y. Chen, Y. Tang, M. Wang, S. Zeng, and D. Nie, Human Pregnane X Receptor and Resistance to Chemotherapy in Prostate Cancer, Cancer Research, vol.67, issue.21, pp.10361-10367
DOI : 10.1158/0008-5472.CAN-06-4758

H. Jiang, K. Chen, J. He, F. Pan, J. Li et al., Association of Pregnane X Receptor with Multidrug Resistance-Related Protein 3 and its Role in Human Colon Cancer Chemoresistance, Journal of Gastrointestinal Surgery, vol.72, issue.10, pp.1831-1838, 2009.
DOI : 10.1007/s11605-009-0964-x

I. Dussault, M. Lin, K. Hollister, E. Wang, T. Synold et al., Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR, Journal of Biological Chemistry, vol.276, issue.36, pp.33309-33312
DOI : 10.1074/jbc.C100375200

L. Moore, B. Goodwin, S. Jones, G. Wisely, C. Serabjit-singh et al., John's wort induces hepatic drug metabolism through activation of the pregnane X receptor United States, Proc Natl Acad Sci, pp.7500-7502

J. Wentworth, M. Agostini, J. Love, J. Schwabe, and V. Chatterjee, St John's wort, a herbal antidepressant, activates the steroid X receptor, Journal of Endocrinology, vol.166, issue.3, pp.11-16, 2000.
DOI : 10.1677/joe.0.166R011

H. Friedman, W. Petros, A. Friedman, L. Schaaf, T. Kerby et al., Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma, Journal of Clinical Oncology, vol.17, issue.5, pp.1516-1525, 1999.
DOI : 10.1200/JCO.1999.17.5.1516

M. Prados, W. Yung, K. Jaeckle, H. Robins, M. Mehta et al., Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium study, Neuro-Oncology, vol.6, issue.1, pp.44-54, 2004.
DOI : 10.1215/S1152851703000292

. Basseville, Molecular Cancer http://www.molecular-cancer.com/content, p.8080, 2011.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Analytical Biochemistry, vol.162, issue.1, pp.156-159
DOI : 10.1016/0003-2697(87)90021-2

L. Fink, W. Seeger, L. Ermert, J. Hanze, U. Stahl et al., Real-time quantitative RT???PCR after laser-assisted cell picking, Nature Medicine, vol.12, issue.11, pp.1329-1333, 1998.
DOI : 10.1016/0076-6879(93)25039-5

V. Lamba, K. Yasuda, J. Lamba, M. Assem, J. Davila et al., PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators, Toxicology and Applied Pharmacology, vol.199, issue.3, pp.251-265
DOI : 10.1016/j.taap.2003.12.027

P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. Mcmahon et al., New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening, JNCI Journal of the National Cancer Institute, vol.82, issue.13, pp.1107-1112, 1990.
DOI : 10.1093/jnci/82.13.1107