The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects., American Journal of Respiratory and Critical Care Medicine, vol.155, issue.6, pp.1828-1834, 1997. ,
DOI : 10.1164/ajrccm.155.6.9196082
Tumor Necrosis Factor Inhibitors for Rheumatoid Arthritis, New England Journal of Medicine, vol.355, issue.7, pp.704-712, 2006. ,
DOI : 10.1056/NEJMct055183
Spleen tyrosine kinases: biology, therapeutic targets and drugs, Drug Discovery Today, vol.15, issue.13-14, pp.517-530, 2010. ,
DOI : 10.1016/j.drudis.2010.05.001
Tyrosine kinase inhibitors: a new approach for asthma, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.53-69, 2004. ,
DOI : 10.1016/j.bbapap.2003.11.013
Syk inhibitors as treatment for allergic rhinitis, Pulmonary Pharmacology & Therapeutics, vol.21, issue.3, pp.461-467, 2008. ,
DOI : 10.1016/j.pupt.2007.06.002
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation, Journal of Pharmacology and Experimental Therapeutics, vol.319, issue.3, pp.998-1008, 2006. ,
DOI : 10.1124/jpet.106.109058
Syk Expression and Novel Function in a Wide Variety of Tissues, Biochemical and Biophysical Research Communications, vol.288, issue.3, pp.495-498, 2001. ,
DOI : 10.1006/bbrc.2001.5788
Intracellular antibodies and challenges facing their use as therapeutic agents, Trends in Molecular Medicine, vol.9, issue.9, pp.390-396, 2003. ,
DOI : 10.1016/S1471-4914(03)00163-1
Intracellular Single-Chain Variable Fragments Directed to the Src Homology 2 Domains of Syk Partially Inhibit Fc??RI Signaling in the RBL-2H3 Cell Line, The Journal of Immunology, vol.169, issue.5, pp.2274-2283, 2002. ,
DOI : 10.4049/jimmunol.169.5.2274
A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally, Journal of Allergy and Clinical Immunology, vol.122, issue.1, pp.188-194, 2008. ,
DOI : 10.1016/j.jaci.2008.04.026
URL : https://hal.archives-ouvertes.fr/inserm-00292498
3D structure of Syk kinase determined by single-particle electron microscopy, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1774, issue.12, pp.1493-1499, 2007. ,
DOI : 10.1016/j.bbapap.2007.10.008
Rationalizing the chemical space of protein???protein interaction inhibitors, Drug Discovery Today, vol.15, issue.5-6, pp.220-229, 2010. ,
DOI : 10.1016/j.drudis.2009.11.007
Reaching for high-hanging fruit in drug discovery at protein???protein interfaces, Nature, vol.12, issue.7172, pp.1001-1009, 2007. ,
DOI : 10.1038/nature06526
The road less traveled: modulating signal transduction enzymes by inhibiting their protein???protein interactions, Current Opinion in Chemical Biology, vol.13, issue.3, pp.284-290, 2009. ,
DOI : 10.1016/j.cbpa.2009.05.125
In Silico-In Vitro Screening of Protein-Protein Interactions: Towards the Next Generation of Therapeutics, Current Pharmaceutical Biotechnology, vol.9, issue.2, pp.103-122, 2008. ,
DOI : 10.2174/138920108783955218
URL : https://hal.archives-ouvertes.fr/inserm-00273685
Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes, Molecular & Cellular Proteomics, vol.4, issue.6, pp.752-761, 2005. ,
DOI : 10.1074/mcp.M400159-MCP200
Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery, Drug Discovery Today, vol.15, issue.15-16, pp.656-667, 2010. ,
DOI : 10.1016/j.drudis.2010.05.015
Fast Structure-Based Virtual Ligand Screening Combining FRED, DOCK, and Surflex, Journal of Medicinal Chemistry, vol.48, issue.19, pp.6012-6022, 2005. ,
DOI : 10.1021/jm050262h