Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound.

Abstract : The activation of natural gas nuclei to induce larger bubbles is possible using short ultrasonic excitations of high amplitude, and is required for ultrasound cavitation therapies. However, little is known about the distribution of nuclei in tissues. Therefore, the acoustic pressure level necessary to generate bubbles in a targeted zone and their exact location are currently difficult to predict. To monitor the initiation of cavitation activity, a novel all-ultrasound technique sensitive to single nucleation events is presented here. It is based on combined passive detection and ultrafast active imaging over a large volume using the same multi-element probe. Bubble nucleation was induced using a focused transducer (660 kHz, f-number = 1) driven by a high-power electric burst (up to 300 W) of one to two cycles. Detection was performed with a linear array (4 to 7 MHz) aligned with the single-element focal point. In vitro experiments in gelatin gel and muscular tissue are presented. The synchronized passive detection enabled radio-frequency data to be recorded, comprising high-frequency coherent wave fronts as signatures of the acoustic emissions linked to the activation of the nuclei. Active change detection images were obtained by subtracting echoes collected in the unnucleated medium. These indicated the appearance of stable cavitating regions. Because of the ultrafast frame rate, active detection occurred as quickly as 330 μs after the high-amplitude excitation and the dynamics of the induced regions were studied individually.
Type de document :
Article dans une revue
IEEE Trans Ultrason Ferroelectr Freq Control, 2011, 58 (3), pp.517-32. 〈10.1109/TUFFC.2011.1836〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00607669
Contributeur : Jérôme Gateau <>
Soumis le : dimanche 10 juillet 2011 - 16:55:44
Dernière modification le : jeudi 11 janvier 2018 - 06:23:18
Document(s) archivé(s) le : dimanche 4 décembre 2016 - 06:25:53

Fichiers

inserm-00607669_edited.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Jérôme Gateau, Jean-François Aubry, Mathieu Pernot, Mathias Fink, Mickaël Tanter. Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound.. IEEE Trans Ultrason Ferroelectr Freq Control, 2011, 58 (3), pp.517-32. 〈10.1109/TUFFC.2011.1836〉. 〈inserm-00607669〉

Partager

Métriques

Consultations de la notice

316

Téléchargements de fichiers

757