PD-L2 is expressed on activated human T cells and regulates their function.

Abstract : T-cell activation and proliferation are regulated by cosignaling adhesion molecules involved in positive or negative signals. Programmed death (PD)-1 is one of immune inhibitory molecules that is expressed in activated T cells and is a promising target for immunotherapy. Both PD-1 ligands, PD-L1 and PD-L2 are expressed on antigen presenting cells (APCs) involved in the dialogue between a T cell and an APC. Here, we analysed the expression of these ligands, especially for PD-L2, on T cells. PD-L2 appears to be expressed on activated CD4 and CD8T cell subsets. Moreover, as PD-1 molecule, PD-L2 engagement at the surface of T cells is able to down-modulate cytokine production and cell proliferation. These observations indicate that PD-L2 is expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network.
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Molecular Immunology, Elsevier, 2011, 48 (15-16), pp.2214-9. 〈10.1016/j.molimm.2011.06.436〉
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http://www.hal.inserm.fr/inserm-00600726
Contributeur : Jacques Nunès <>
Soumis le : mardi 10 janvier 2012 - 18:42:56
Dernière modification le : jeudi 18 janvier 2018 - 01:48:49
Document(s) archivé(s) le : mercredi 11 avril 2012 - 02:21:09

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Nassima Messal, Nacer-Eddine Serriari, Sonia Pastor, Jacques Nunès, Daniel Olive. PD-L2 is expressed on activated human T cells and regulates their function.. Molecular Immunology, Elsevier, 2011, 48 (15-16), pp.2214-9. 〈10.1016/j.molimm.2011.06.436〉. 〈inserm-00600726〉

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