Astroglial networks scale synaptic activity and plasticity.

Abstract : Astrocytes dynamically interact with neurons to regulate synaptic transmission. Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic physiology is unknown. Here we show, by inactivating Cx30 and Cx43 genes, that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. This regulation limits neuronal excitability, release probability, and insertion of postsynaptic AMPA receptors, silencing synapses. By controlling synaptic strength, connexins play an important role in synaptic plasticity. Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
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Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2011, epub ahead of print. 〈10.1073/pnas.1016650108〉
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Soumis le : mardi 10 mai 2011 - 23:07:24
Dernière modification le : jeudi 11 janvier 2018 - 06:23:24

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Ulrike Pannasch, Lydia Vargova, Jurgen Reingruber, Pascal Ezan, David Holcman, et al.. Astroglial networks scale synaptic activity and plasticity.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2011, epub ahead of print. 〈10.1073/pnas.1016650108〉. 〈inserm-00592041〉

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