PMID: identifiant
de la référence Pubmed : |
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 (21524251)  |
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| titre : |
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VIP-induced neuroprotection of the developing brain. |
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| auteur(s) : |
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Sandrine Passemard1, 2, 3, 4, Paulina Sokolowska1, 2, 5, Leslie Schwendimann1, 2, Pierre Gressens ( ) 1, 2, 3, 6 |
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| laboratoire : |
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| résumé : |
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Excitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits. VIP induces a potent neuroprotection against perinatal excitotoxic white matter damage. VIP does not prevent the initial appearance of white matter lesion but promotes a secondary repair with axonal regrowth. This plasticity mechanism involves an atypical VPAC2 receptor and BDNF production. Stable VIP agonists mimic VIP effects when given systemically and exhibit a large therapeutic window. Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults. |
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| domaine : |
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Sciences du Vivant/Neurosciences
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1873-4286 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| journal : |
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Curr Pharm Des |
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| Audience : |
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internationale |
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| date de publication : |
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2011 |
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date de publication
électronique : |
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18/03/2011 |
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| volume : |
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17 |
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| numéro : |
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10 |
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| page, identifiant, ... : |
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1036-9 |
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| mots-clés auteur : |
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neuroprotection – cerebral palsy – plasticity – preterm infant – VPAC receptor – NAP – excitotoxicity. |
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| Descripteur(s) MeSH : |
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Animals – Brain – Cerebral Palsy – Humans – Neuronal Plasticity – Neuroprotective Agents – Receptors – Vasoactive Intestinal Peptide – Type II – Signal Transduction |
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